Overview of the IVIO Trial Design

The Danish IVIO trial, a multicenter open-label randomized controlled study, investigated the effectiveness of intraosseous (IO) versus intravenous (IV) access during adult cardiac arrest, focusing on drug administration for those in need. Conducted in Denmark from 2022 to 2024, it involved approximately 1,500 patients, with 731 assigned to the IO group and 748 to the IV group. The primary outcome measured was the return of spontaneous circulation (ROSC), which was achieved in 30% of the IO group compared to 29% of the IV group, indicating no significant difference in immediate resuscitation success. The findings align with ongoing discussions in the cardiac arrest community regarding the implications of vascular access routes on drug efficacy during emergencies, particularly emphasizing the growing trend toward IO access in pre-hospital settings.