Lars Wiuff Andersen, a leading expert in pre-hospital critical care, and Mikael Fink Valentine, a researcher in cardiac arrest, delve into the findings of the groundbreaking IVIO trial. They compare intraosseous and intravenous access methods during out-of-hospital cardiac arrests. The discussion reveals similar efficacy between the two techniques, emphasizing the importance of skilled emergency teams. Insights into medication access routes and the implications of trial outcomes for future emergency practices are particularly fascinating.

Theresa Olasveengen, Victoria Cornelius, and Christopher Seymour join trialists Mikael Fink Vallentin and Lars Andersen, as well as editorialist Gavin Perkins, to discuss the COCA trial. They explore the stone heart phenomenon, the use of dual analytic approaches in trials, and reflections on trial design and execution.