

COCA Trial Panel Discussion
Dec 6, 2021
Guest
Victoria Cornelius
Guest
Theresa Olasveengen
Guest
Mikael Fink Vallentin
Guest
Lars Andersen
Guest
Christopher Seymour
Guest
Gavin Perkins
Theresa Olasveengen, Victoria Cornelius, and Christopher Seymour join trialists Mikael Fink Vallentin and Lars Andersen, as well as editorialist Gavin Perkins, to discuss the COCA trial. They explore the stone heart phenomenon, the use of dual analytic approaches in trials, and reflections on trial design and execution.
Chapters
Transcript
Episode notes
1 2 3 4 5 6
Introduction
00:00 • 3min
Sample Size Calculation and Stopping Criteria
03:01 • 7min
Harm Mechanism and Stone Heart Phenomenon
10:25 • 4min
The Use of Dual Analytic Approaches in Trials
14:17 • 14min
Stratification and Adjusting for Prognostic Factors in Study Analysis
28:01 • 2min
Reflections on Trial Design and Execution
29:40 • 7min