Vital Signs with Jacob Effron and Nikhil Krishnan

Virgílio Bento, Sword Health CEO, discusses the company's new AI care model, key decisions, customer acquisition, challenges in the US healthcare system, and flying across the world for dinner with Vinod Khosla.

Dr. Atul Butte, a professor at UCSF and Chief Data Scientist of the UC Health System, discusses healthcare AI opportunities, challenges, hype, and more. Topics include AI adoption timeline, converting skeptical doctors, commercialization in AI, regulating consumer-facing AI apps, coolest AI demos, and what company Dr. Butte would want to run.

Former Secretary of Veterans Affairs Dr. David Shulkin discusses innovating within the VA, access to healthcare for veterans, setting priorities as a leader, EHR rollout, successful startups in the VA, changes in medical education, applications of AI in healthcare, and more with hosts Jacob and Nikhil.

Jacob and Nikhil sit down with Jean-Charles Samuelian-Werve, Co-Founder and CEO of Alan. Alan is a multi-billion dollar French health insurance company that has expanded to become an all-in-one health platform for its consumers. They discuss Alan’s product strategy and business model, building AI for healthcare companies, what healthcare looks like in Europe, and more. (0:00) intro(0:47) French healthcare 101(6:30) similarities with Oscar (9:50) building a healthcare super-app(15:11) medical loss ratio(21:58) contracting with providers(29:29) optimizing Alan for different countries/continents  (35:08) finding new users(38:17) AI in healthcare(48:31) over-hyped/under-hyped(50:36) healthcare policy changes Jean-Charles would make in France Out-Of-Pocket: https://www.outofpocket.health/

Jacob and Nikhil sit down with Malay Gandhi, Head of Strategy & Corporate Development at Benchling. Malay previously served as CEO of Rock Health and SVP of Business Operations at Evidation Health, and his seminal pieces helped shape early digital health thinking. They discuss some of Malay’s early pieces, the future of life sciences & real-world evidence, building & scaling software at Benchling, and more. (0:00) intro(0:58) how Malay feels about his old essays(8:00) the Benchling story(16:29) serving customers in different industries(22:12) how will AI change Benchling(29:49) the state of tech in biopharma(38:41) the real-world experiment(42:04) have trial designs changed?(46:24) over-hyped/under-hyped Out-Of-Pocket: https://www.outofpocket.health/

Exploring risk-based contracts, value-based care for specialists, and incubating companies in healthcare innovation. Insights from Will Stokes at Strive Health on primary care for specialized conditions and using LLMs. Negotiating contracts, surprises in building Strive, and when risk-based models make sense.

Dr. Amy Abernethy discusses real-world evidence, control arms in clinical trials, generative AI in healthcare, Verily's growth, and her new venture. Exploring the future of healthcare innovation and regulatory challenges. Sharing insights on improving healthcare in the U.S.

Mario Schlosser, Co-Founder of Oscar Health, discusses the impact of AI in healthcare, limitations of GPT-4, and why we can't have robot doctors. They also talk about sharing AI knowledge, developing healthcare-specific models, and the need for a safety layer in LLMs. Other topics include commercial opportunities in healthcare, the possibility of AI doctors, and overhyped/underhyped aspects of AI. Oscar Health's unique approach and their interest in exploring AI use cases in gaming are also highlighted.

Sarah London, CEO of Centene Corporation, discusses Medicaid partnerships and redeterminations, SDoH innovation and outcomes, and payers vertically expanding their ownership. They also explore the potential of Gen AI in healthcare and the evolving landscape of individual health insurance.

Jacob sits down with Dr. Ezekiel Emanuel again to discuss the future of health policy and care delivery, hyped innovations in healthcare, market trends among payers and providers, and more.  (0:00) intro(0:57) generative AI(4:08) the ethics of NOT using AI(7:04) ML-based risk adjustment(11:46) why didn’t hospitals become payers?(19:37) what does the future of hospitals look like?(26:15) can insurance cover mental health treatment for everybody?(29:45) GLP-1s(35:02) the future of healthcare policy(41:07) what should we be learning from the way other countries do healthcare?(45:57) Ben Franklin(49:37) Zeke Bar update Out-Of-Pocket: https://www.outofpocket.health/