
Vital Signs with Jacob Effron and Nikhil Krishnan
On Vital Signs, Jacob Effron and Nikhil Krishnan dig into cutting-edge trends in healthtech and the people shaping them. Every two weeks they’ll explore a new sub-sector and trend with policy leaders, startup founders and industry executives.
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Latest episodes

10 snips
Oct 10, 2024 • 37min
Ep 50: Carelon Health President Bryony Winn on How Payers Think About Provider Strategy, Startups and Value-Based Care
Bryony Winn, President of Carelon Health and a leader in advanced primary care, shares insights on the evolving healthcare landscape. She discusses the critical role of payers in fostering effective provider partnerships and enhancing value-based care. Bryony highlights the challenges and innovations in integrating behavioral health and the significant impact of generative AI on operations. She also reflects on the importance of collaboration, especially in the context of mental health support for working parents, emphasizing a holistic approach to healthcare.

Sep 11, 2024 • 48min
Ep 49: Equip CEO Kristina Saffran on Effective Eating Disorder Treatments and Scaling New Care Models
Jacob sits down with Kristina Saffran, the Co-Founder and CEO of Equip. Equip delivers at-home, virtual eating disorder treatment for both adolescents and adults. They discuss Kristina’s journey to founding Equip, getting payors on board, evidence-based treatments for eating disorders, and more. [0:00] Intro[1:06] Kristina's Personal Journey[3:27] Founding Project Heal [4:07] Challenges in Eating Disorder Treatments [5:15] The Role of Evidence-Based Treatments [6:40] Transition to Venture-Backed Startup [13:33] Virtual Care Model for Eating Disorders [17:23] Adapting Treatment for Different Populations [22:42] Working with Insurance Companies [24:37] Equip's Year-Long Care Program [25:15] Challenges in Operationalizing Innovative Payment Models [28:21] Patient Archetypes and Outreach Strategies [32:41] Provider Education and Partnerships [34:16] Growth and Future Plans for Equip [39:07] The Role of Peer Support in Treatment [43:05] Quickfire Out-Of-Pocket: https://www.outofpocket.health/

Jul 25, 2024 • 34min
Ep 48: Savvy CEO Suril Kantaria on First Time Founder Lessons and ICHRA
Jacob and Nikhil sit down with Savvy CEO Suril Kantaria to discuss the future of the ICHRA market and what he would do differently if he was starting Savvy today. [00:00] intro[00:35] ICHRA[06:20] is this better for employees?[15:20] is ICHRA policy doomed to fail?[19:10] venture’s role in healthcare[24:00] early founders building in “stealth”[29:00] making the decision to “stop” as a founder Out-Of-Pocket: https://www.outofpocket.health/

Jul 10, 2024 • 45min
Ep 47: Former One Medical/Stanford CEO Amir Dan Rubin on Payviders, One Medical Reflections and Gen AI
Former One Medical and Stanford CEO, Amir Dan Rubin, discusses payer-provider integrations, lessons from leading One Medical, generative AI applications, future of health systems, staffing shortages, hospitals investing in companies, Amazon's acquisition of One Medical, and more

14 snips
Jun 17, 2024 • 39min
Ep 46: Humana Primary Care CMO Dr. Vivek Garg on Next Gen Primary Care Lessons and Effective Payer Partnerships
Dr. Vivek Garg, CMO at Humana, discusses primary care, value-based care models, AI in healthcare, and challenges in healthcare innovation. Topics include payer acquisitions, ambient clinical documentation, and overhyped/underhyped health tech aspects.

15 snips
Jun 5, 2024 • 52min
Ep 45: Sword Health CEO Virgílio (“V”) Bento on Sword's New AI Solution and the Decisions That Shaped the Company
Virgílio Bento, Sword Health CEO, discusses the company's new AI care model, key decisions, customer acquisition, challenges in the US healthcare system, and flying across the world for dinner with Vinod Khosla.

17 snips
May 7, 2024 • 49min
Ep 44: Dr. Atul Butte on Healthcare AI Opportunities and Challenges
Dr. Atul Butte, a professor at UCSF and Chief Data Scientist of the UC Health System, discusses healthcare AI opportunities, challenges, hype, and more. Topics include AI adoption timeline, converting skeptical doctors, commercialization in AI, regulating consumer-facing AI apps, coolest AI demos, and what company Dr. Butte would want to run.

4 snips
Apr 23, 2024 • 51min
Ep 43: Former Secretary of Veterans Affairs Dr. David Shulkin on Transforming the VA & Getting Public-Private Partnerships Right
Former Secretary of Veterans Affairs Dr. David Shulkin discusses innovating within the VA, access to healthcare for veterans, setting priorities as a leader, EHR rollout, successful startups in the VA, changes in medical education, applications of AI in healthcare, and more with hosts Jacob and Nikhil.

Apr 9, 2024 • 54min
Ep 42: Alan CEO Jean-Charles Samuelian-Werve on Building a Healthcare Superapp & the Future of Healthcare in Europe
Jacob and Nikhil sit down with Jean-Charles Samuelian-Werve, Co-Founder and CEO of Alan. Alan is a multi-billion dollar French health insurance company that has expanded to become an all-in-one health platform for its consumers. They discuss Alan’s product strategy and business model, building AI for healthcare companies, what healthcare looks like in Europe, and more. (0:00) intro(0:47) French healthcare 101(6:30) similarities with Oscar (9:50) building a healthcare super-app(15:11) medical loss ratio(21:58) contracting with providers(29:29) optimizing Alan for different countries/continents (35:08) finding new users(38:17) AI in healthcare(48:31) over-hyped/under-hyped(50:36) healthcare policy changes Jean-Charles would make in France Out-Of-Pocket: https://www.outofpocket.health/

Mar 26, 2024 • 56min
Ep 41: Benchling Head of Strategy Malay Gandhi on the Future of Life Sciences Software and The Evolution of Digital Health
Jacob and Nikhil sit down with Malay Gandhi, Head of Strategy & Corporate Development at Benchling. Malay previously served as CEO of Rock Health and SVP of Business Operations at Evidation Health, and his seminal pieces helped shape early digital health thinking. They discuss some of Malay’s early pieces, the future of life sciences & real-world evidence, building & scaling software at Benchling, and more. (0:00) intro(0:58) how Malay feels about his old essays(8:00) the Benchling story(16:29) serving customers in different industries(22:12) how will AI change Benchling(29:49) the state of tech in biopharma(38:41) the real-world experiment(42:04) have trial designs changed?(46:24) over-hyped/under-hyped Out-Of-Pocket: https://www.outofpocket.health/