80,000 Hours Podcast

Matt Clancy, an economist and research fellow at Open Philanthropy, dives into the dual-edged sword of scientific progress. He discusses the risk of accelerating research, particularly in genetic engineering, and the moral implications that follow. Clancy emphasizes the need for careful funding decisions to mitigate dangers like engineered pandemics. The conversation explores the economic returns of science and the importance of a balanced approach in navigation between innovation and existential risks, ultimately spotlighting the potential and pitfalls of rapid advancement.

Zach Weinersmith, the mind behind Saturday Morning Breakfast Cereal, dives into the deep complexities of space settlement in this engaging discussion. He shares his transformation from a space optimist to a skeptic, scrutinizing the bleak realities of Martian life, where labor mobility could be non-existent. The conversation also highlights the importance of governance in space, warning of potential exploitation in company towns. Expect a mix of humor and critical insights as they reflect on the profound challenges humanity faces beyond Earth.

In this engaging discussion, Dean Spears, an associate professor at the University of Texas at Austin and founding director of r.i.c.e., sheds light on the critical neonatal health challenges in Uttar Pradesh, India. He reveals shocking neonatal mortality rates and explores the effective kangaroo mother care program, emphasizing its life-saving impact through skin-to-skin contact. The conversation also touches on the socioeconomic factors affecting maternal and infant health, and the hope for future improvements through innovative, low-cost healthcare solutions.

Lewis Bollard, Director of the Farm Animal Welfare program at Open Philanthropy, dives into the urgent issues of factory farming. He discusses innovative solutions to alleviate animal suffering and the risks posed by AI in this context. Bollard outlines promising strategies to improve animal welfare, including corporate accountability and plant-based alternatives. The conversation also touches on recent legal victories and the global evolution of animal rights advocacy, igniting hope for a more humane future in food production.

Zvi Mowshowitz, author of the Substack "Don’t Worry About the Vase," shares his deep insights on AI developments and ethical dilemmas. He discusses the pressing issue of sleeper agents in AI, highlighting the challenges of alignment and safety. Zvi critiques current AI regulations and debates the effectiveness of major labs' safety strategies. He also explores the moral implications of working in AI, encouraging listeners to consider the impact of their choices. His perspective on policy reform reveals innovative ideas to address societal challenges.

Cody Fenwick, a research colleague focused on AI governance, dives deep into the critical intersection of advanced AI and policy. He outlines the potential global risks posed by AI systems and emphasizes the vital role of skilled professionals in steering governance to avoid exacerbating these threats. The discussion covers diverse career pathways, the value of effective communication, and the need for collaboration among stakeholders. Fenwick also highlights the importance of assessing personal fit and building career capital in this evolving landscape.

Spencer Greenberg, a serial entrepreneur and host of the Clearer Thinking podcast, dives into intriguing discussions about money and happiness, revealing the complexities of their relationship. He shares insights on recognizing toxic behaviors in relationships, emphasizing the importance of self-awareness. The conversation also touches on the balance between hype and genuine value in marketing, and explores the significance of personal guiding principles in decision-making. Finally, Spencer highlights the role of rationality in addressing societal challenges.

In this engaging conversation, Bob Fischer, a senior research manager at Rethink Priorities and director of the Society for the Study of Ethics and Animals, delves into animal welfare nuances. He explores the complex sentience of various beings—from chickens to octopuses—highlighting their emotional capacities and ethical implications. Fischer discusses the challenges of quantifying welfare and consciousness across species and urges a reassessment of how we prioritize suffering, prompting listeners to rethink their values regarding animal rights and welfare.

Laura Deming, the founder of The Longevity Fund and a venture capitalist in anti-aging technology, discusses transformative ideas around human longevity. She explores how we might manipulate aging in humans, not just accept decline as inevitable. Laura highlights a recent breakthrough in lifespan extension for dogs and emphasizes a social approach to the challenge of aging. She advocates for agency over our health choices and envisions a world where extended lifespans allow us to remain active and engaged well into our later years.

Hugo Mercier, a cognitive scientist from the CNRS and author of "Not Born Yesterday," shares his insights on human gullibility and the misconception surrounding misinformation. He argues that people have evolved reasoning skills that promote beneficial communication rather than blind trust. The discussion covers how social context influences belief updates, the psychological dynamics of trust, and the potential impacts of AI on misinformation. Mercier challenges the prevalent view that gullibility and disinformation are major threats, emphasizing the perceptiveness of ordinary individuals.