Investigative journalist Alison Young discusses lab leaks and biosafety failures, including incidents at the CDC, the Soviet anthrax leak, the 1977 influenza pandemic, and the last smallpox death. The podcast explores the need for reliable oversight, accountability, and safety culture in labs handling dangerous pathogens. It highlights the potential impacts of lab leaks, the challenges in establishing a safety culture, and the contrasting safety cultures in the nuclear and biological sciences. The importance of safe biological research and the bipartisan interest in lab safety are also discussed.
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Quick takeaways
Lab leaks have occurred in the past and pose a real risk to public health.
The CDC has made biosafety mistakes, revealing a lack of transparency and accountability.
Lab accidents highlight the need for stringent safety protocols, improved transparency, and knowledge.
Deep dives
Microbiology labs historically had risky practices
Microbiology labs historically had risky practices due to the absence of safety measures and a culture that embraced infections as battle scars rather than safety concerns.
CDC's biosafety mistakes
The CDC had several biosafety mistakes, including power outages affecting airflow systems, unsafe practices in handling anthrax, and labeling errors with live anthrax. These incidents highlight a lack of transparency and accountability in lab safety oversight.
Lab leaks and their potential dangers
Lab leaks can have significant impacts, causing localized outbreaks or environmental contamination. Examples include the accidental release of live anthrax spores from the Dugway Life Science Test Facility and a lab-associated influenza pandemic in 1977. These incidents underscore the need for stringent safety protocols and effective oversight.
Lessons learned and the importance of data
The cases discussed reveal the human fallibility involved in lab accidents. They demonstrate the risks posed by complacency, inadequate training, and poor safety culture. Additionally, the lack of universal data collection and reporting systems for lab accidents and infections highlights the need for improved transparency and knowledge to prevent future incidents.
Underreported lab accidents and infections
Lab accidents and infections in federal select agent labs have been significantly underreported. Over the span of six years, hundreds of lab accidents have been reported, but these numbers are likely an undercount due to the culture of underreporting that exists. It is also challenging to determine the frequency of lab worker infections, although infections are believed to be relatively rare. A biosafety expert found that between 1979 and 2015, there were approximately 2,230 lab-associated infections and 41 deaths reported. However, these incidents reflect only what has been publicly reported, and there may be a greater number of unreported cases.
The need for improved reporting and oversight
There is resistance from the biological research community to publicly report laboratory incidents, accidents, and infections. Some argue that it is a national security issue, although they freely publicize positive information about their experiments. Legislation is being considered in the US Congress to create a reporting system for lab accidents, but it currently only allows for voluntary reporting and exempts the information from the Federal Freedom of Information Act. Calls have been made for a single federal agency to oversee lab safety and to harmonize regulations, similar to how the Nuclear Regulatory Commission operates. Transparency and increased funding for biosafety research are also seen as crucial for improving lab safety. The fragmented and overlapping regulatory system, potential conflicts of interest, and lack of tracking and coordination contribute to the challenges in ensuring lab safety.
"Rare events can still cause catastrophic accidents. The concern that has been raised by experts going back over time, is that really, the more of these experiments, the more labs, the more opportunities there are for a rare event to occur — that the right pathogen is involved and infects somebody in one of these labs, or is released in some way from these labs. And what I chronicle in Pandora's Gamble is that there have been these previous outbreaks that have been associated with various kinds of lab accidents. So this is not a theoretical thing that can happen: it has happened in the past." — Alison Young
In today’s episode, host Luisa Rodriguez interviews award-winning investigative journalist Alison Young on the surprising frequency of lab leaks and what needs to be done to prevent them in the future.
The most egregious biosafety mistakes made by the CDC, and how Alison uncovered them through her investigative reporting
The Dugway life science test facility case, where live anthrax was accidentally sent to labs across the US and several other countries over a period of many years
The time the Soviets had a major anthrax leak, and then hid it for over a decade
The 1977 influenza pandemic caused by vaccine trial gone wrong in China
The last death from smallpox, caused not by the virus spreading in the wild, but by a lab leak in the UK
Ways we could get more reliable oversight and accountability for these labs
And the investigative work Alison’s most proud of
Chapters:
Cold open (00:00:00)
Luisa's intro (00:01:13)
Investigating leaks at the CDC (00:05:16)
High-profile CDC accidents (00:16:13)
Dugway live anthrax accidents (00:32:08)
Soviet anthrax leak (00:44:41)
The 1977 influenza pandemic (00:53:43)
The last death from smallpox (00:59:27)
How common are lab leaks? (01:09:05)
Improving the regulation of dangerous biological research (01:18:36)
Potential solutions (01:34:55)
The investigative work Alison’s most proud of (01:40:33)
Producer and editor: Keiran Harris Audio Engineering Lead: Ben Cordell Technical editing: Simon Monsour and Milo McGuire Additional content editing: Katy Moore and Luisa Rodriguez Transcriptions: Katy Moore
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