An increasing number of people are dying from misuse of synthetic opioids. In 2022, the US recorded over 70,000 overdose deaths involving synthetic opioids. The government is spending billions to combat the effects of these super strength drugs. Synthetic opioids, such as Fentanyl, are made in laboratories by using materials derived from the opium poppy. China is a major hub for the production of synthetic opioids, where it then makes its way to North America through Mexican drug cartels. The lab-made drugs can be more deadly than the natural materials, but they are more easily accessible, and prevalence is rising across the world.In West Africa and the Middle East, tramadol is one of the most consumed synthetic drugs. The rise of synthetic opioids in the European market, which are being used as a substitute for a heroin shortage, is fuelling concern that these substances could lead to a rise in drug-related deaths. This week on The Inquiry, we’re asking are synthetic opioids a global problem?Contributors Ric Treble, Forensic chemist and advisor to the Government’s Advisory Council on the Misuse of Drugs Dr Angela Me, Chief of the Research and Trend Analysis Branch from the United Nations Office on Drugs and Crime Ben Westhoff, author of Fentanyl, Inc and investigative journalist Dr Vanda Felbab-Brown is a senior fellow in the Strobe Talbott Center for Security, Strategy, and Technology in the Foreign Policy program at Brookings InstitutionProduction team Presenter: Charmaine Cozier Producers: Vicky Carter and Matt Toulson Researcher: Ajai Singh Editor: Tara McDermott Technical Producer: Cameron Ward Production Co-ordinator: Liam MorreyImage credit: mikroman6 via Getty Images

Six months into Israel’s war in Gaza and with no sign of a ceasefire or breakthrough in securing the release of the 130 hostages, as yet unaccounted for, pressure is mounting on Israel’s Prime Minister Benjamin Netanyahu. There have been widespread protests in Tel Aviv and across Israel. There have been calls both from home and abroad for an early election to be called. And Israel’s greatest ally, the United States has sharpened its rhetoric in the past few weeks over Israel’s conduct of the war, with President Biden now saying that he believes Benjamin Netanyahu is making ‘a mistake’ in his handling of it. For his part, the Israeli Prime Minister looks set to continue with his military offensive and has shown no indication so far that he is willing to step down or call an early election. So, on this week’s Inquiry, we’re asking ‘How secure is Benjamin Netanyahu’s leadership?’Contributors: Professor David Tal, the Yossi Harel Chair in Modern Israel Studies, University of Sussex, UK Natan Sachs, Director of the Centre for Middle East Policy, The Brookings Institution, Washington DC, USA Aaron David Miller, Senior Fellow, Carnegie Endowment for International Peace, Washington DC, USA Professor Tamar Hermann, Senior Research Fellow, The Israel Democracy Institute, JerusalemPresenter: Tanya Beckett Producer: Jill Collins Editor: Tara McDermott Technical Producer: Cameron Ward Production Co-ordinator: Liam MorreyImage credit: Reuters via BBC Images

Multiple Sclerosis (MS) is a neurological disease which can lead to loss of mobility and vision. Almost 3 million people worldwide are affected by it. There is no cure, but attempts are being made to accelerate the healing process with treatments to restore what the disease has damaged.At the same time, scientists have recently discovered a link between MS and a common virus that the majority of us carry in our bodies. It had been known for years that there was a link between Multiple Sclerosis and Epstein-Barr virus (EBV). But then, a study finally proved the link.Now, trials are underway on potential vaccines against EBV and scientists are hopeful that this could be a gateway to preventing MS. This week on the Inquiry we are asking: Are we close to a breakthrough for Multiple Sclerosis?Contributors:Tim Coetzee, Chief Advocacy, Services & Science Officer for the National MS Society, US Tjalf Ziemssen, Professor of Clinical Neuroscience and Head of the Multiple Sclerosis Center and Neuroimmunological Laboratory, University Clinic Carl-Gustav Carus, Germany Jeffrey Huang, Associate Professor of Biology, Georgetown University, US Claire Shannon-Lowe, Associate Professor in Virology, Institute of Immunology and Immunotherapy at the University of Birmingham, UKProduction team: Presenter: Tanya Beckett Producer: Matt Toulson Researcher: Ajai Singh Editor: Tara McDermott Studio Manager: Hal Haines Production Co-ordinator: Liam MorreyImage Credit: Shidlovski\Getty

Explore the impact of climate change on cocoa production, with a focus on the challenges faced by small-scale farmers in West Africa. Delve into the historical evolution of cocoa production and the implications of climate change on chocolate prices. Discover the strategies and regulations in Ghana's cocoa industry and the importance of sustainable production practices. Learn about the emerging markets driving cocoa demand and the crucial role of cocoa farmers in ensuring future supplies.

In February this year, El Salvador's president Nayib Bukele won re-election with nearly 85% of the vote. His flagship policy after he came to power in 2019 has been the mass arrest of thousands of alleged gang members, mainly young men.It is estimated that over 100,000 people are now behind bars as part of his crime crackdown. The round-ups have been hugely popular with El Salvador's people as it has improved security and neighbouring countries are taking note.But critics say following Bukele's approach could threaten democracy, not just in El Salvador but across the continent. So on this week’s Inquiry, we’re asking: Will neighbouring countries follow El Salvador's lead on crime?Contributors: Carlos Dada, director of El Faro, an online newspaper based in El Salvador Katherine Saunders-Hastings, a lecturer in Latin American Studies at the University of London's Institute of the Americas. Will Freeman, Fellow for Latin American Studies at the Council on Foreign Relations, New York. Monica Pachon , a political scientist and professor at the University of the Andes in Bogotá, Colombia.Presenter: David Baker Producer: Farhana Haider Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Nicky Edwards Production Co-ordinator: Tim Fernley and Liam MorreyImage Credit: Alex Peña / Stringer via Getty Images

Exploring the future of urban underground living in response to increasing urbanization and extreme weather caused by climate change. Discussing the history and benefits of living underground, challenges faced by architects and urban planners, and the potential for innovative urban underground spaces like underground farms and transportation systems.

The Mexican government has won its appeal to bring a civil lawsuit against a number of American gun companies. Mexico, which has extremely restrictive gun laws, claims that the ‘deliberate’ business practices of these US firms results in the illegal flow of firearms into Mexico, contributing to the gun crime violence in the country. They are now seeking as much as ten billion dollars in compensation. The gun companies, which include some of America’s oldest established names in the firearms business, deny any wrongdoing. Since 2005, these companies have being granted immunity from prosecution under the ‘Protection of Lawful Commerce in Arms Act’. This law protects the firearms manufacturers and dealers from being held liable when crimes have been committed with their products. But Mexico’s argument is that PLCAA, as it’s also known, only applies within the United States and therefore doesn’t protect the companies from liability.It’s a case which is also resonating with other Latin American countries who have been impacted by illegal gun trafficking from the United States. Some of these countries have supported Mexico’s claims in the courts. And they will be watching closely to see if Mexico’s lawsuit, the first by a sovereign state, can set a precedent.So on this week’s Inquiry, we’re asking ‘Can Mexico win its battle with US gun companies?’Contributors: Ioan Grillo, journalist and author focusing on Organised Crime, Mexico Adam Winkler, Cornell Professor of Law, UCLA School of Law, California, USA Robert Spitzer, Distinguished Service Professor Emeritus of Political Science, SUNY Cortland; Adjunct Faculty Member, College of William and Mary School of Law, USA Dr. León Castellanos-Jankiewicz, Senior Researcher, Asser Institute for International and European Law; Academic Supervisor, International Law Clinic on Access to Justice for Gun Violence, University of Amsterdam, The Netherlands. Presenter: Charmaine Cozier Producer: Jill Collins Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Cameron Ward Production Co-ordinator: Liam Morrey Image: Reuters via BBC Images

The podcast delves into the controversy surrounding the restoration plans for Menkaure's pyramid in Egypt, with archaeologists and Egyptologists divided on the proper preservation methods. The debate highlights the delicate balance between restoration and conservation of ancient archaeological sites, sparking a global discussion on the topic. The project has been paused after recommendations from a scientific committee, leaving the future of the pyramid restoration uncertain.

Across the world fertility rates are falling and for the first time Europe is experiencing a sustained population decline. The average fertility rate for the European Union is 1.53 live births per woman. In Italy the fertility rate has remained low for the last thirty years, with an average 1.3 births per woman.Some governments, who are concerned that not enough people are being born to keep their economies functioning in the long term are spending billions on incentives and policies to try and reverse the trend. But even in the Nordic countries, which are noted for some of the best family focused policies, these are proving ineffective against a markedly high drop in fertility rates over the last decade. Society’s attitudes on when or whether to start a family are shifting, so does this mean that we need to change the way we approach the issue or even adapt to a future with fewer people? On this week’s Inquiry, we’re asking ‘Can Europe reverse its falling fertility rates?’Contributors: Anna Rotkirch, Research Director, Population Research Institute, The Family Federation of Finland, Helsinki Michael Herrmann, Senior Advisor on Economics and Demography, United Nations Population Fund (UNFPA), Turkey Arnstein Aassve, Professor of Demography, Political Science Centre, Bocconi University, Milan, Italy Tomas Sobotka, Deputy Director, Vienna Institute of Demography, Austrian Academy of Sciences Presenter: Charmaine Cozier Producer: Jill Collins Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producers: Nicky Edwards and Toby James Production Co-ordinator: Liam Morrey Image Credit: PA via BBC Images

In the next two or three years America’s National Aeronautics and Space Administration - NASA - plans to send a mission into space that will land people on the moon for the first time in over a half a century.The mission has already been pushed back and is widely expected to be delayed again.But America is not alone. Both China and India also have ambitions to land people on the lunar surface.Who is next to walk on the moon is driven by geopolitics and a desire to harness the moon’s resources. Different countries, and even the private companies involved, all have different agendas. Who gets there first may even determine the political ideology of any future permanent human settlement. Contributors: Oliver Morton, Senior Editor at The Economist and author of The Moon, A History for the Future Eric Berger, Senior Space Editor at Ars Technica Christopher Newman, Professor of space law and policy at Northumbria University Namrata Goswami, Professor at the Thunderbird School of Global Management at Arizona State UniversityPresenter: Tanya Beckett Producer: Louise Clarke Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Richard Hannaford Production Coordinator: Liam MorreyImage: U.S. Flag On The Moon by Encyclopaedia Britannica via Getty Images Credit: NASA Youtube Channel