The Curious Clinicians

Medical student Giancarlo Buonomo joins the podcast to discuss the complexities of systemic pulmonary vasodilators in COPD patients with pulmonary hypertension. The episode explores the impact of sildenafil, inhaled vasodilators, and supplemental oxygen therapy on blood oxygen levels and vascular functions in lung diseases.

Discover the science behind why our fingertips wrinkle in water, debunking the myth of dehydration as the cause. Explore the mechanics of water entry into the skin, the role of sweat glands and nerve system, and the evolutionary advantage of aquagenic wrinkling for grip efficiency. Learn how patients with Hansen's disease lack this ability due to nerve involvement.

In this episode from our archives, originally posted on September 16, 2020, The Curious Clinicians examined why the savory flavor umami is SO DELICIOUS. Dig in! Show notes: https://curiousclinicians.com/2020/09/16/episode-9-why-is-umami-so-delicious/ CME: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians Audio edited by Clair Morgan of Nodderly      

Exploring the physiological effects of chronic alcohol use on red blood cells, the podcast highlights macrocytosis and its correlation with alcohol consumption. They delve into the mechanisms behind red blood cell enlargement, including acetaldehyde effects, cytoskeletal changes, and electrolyte equilibrium in alcohol-related hepatitis.

Dr. Jeff Kott, a nephrology specialist, discusses phosphate binders in acute kidney injury and the usefulness of urine anion gap in non-gap metabolic acidosis. The podcast explores NephMadness 2024 and the impact of TWDFNR practices on patient care. It delves into the debate on nephrology selections, patient-centered AKI treatment options, and emphasizes informed decision-making in nephrology.

Delving into the evolutionary advantage of hereditary hemochromatosis and its link to iron regulation. Exploring the historical context and implications of HFE gene mutations on health. Examining the connection between hemochromatosis, iron accumulation, and infections like tuberculosis. Discussing how genetic variations may have influenced resistance to diseases and impacted athletic performance. Exploring the survival advantages conferred by HFE gene variants and ongoing immune-related research.

Debunking the belief of direct bacteria translocation in cirrhosis patients with SBP. Exploring the presence of intestinal bacterial overgrowth and its connection to various factors. Understanding the intricate bacterial pathway in SBP and the role of altered immunity. Emphasizing the relationship between SBP, bacteremia, and gram-negative bacteria in ascitic fluid.

The podcast explores the history and mechanisms of thalidomide, a teratogen that caused birth defects in thousands of babies. Topics covered include the development and marketing of thalidomide, the devastating impact on pregnant women, the mechanisms of thalidomide embryopathy, and the contrasting actions of individuals in drug regulation.

On this episode from our archive, originally posted on February 16, 2022, The Curious Clinicians investigate why antiphospholipid antibodies can be falsely positive during acute illness or thrombosis. Read the show notes here.  Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. 

Discover why normal hemoglobin levels aren't always necessary for transfusions. Explore the evolution of blood transfusion practices from bloodletting to modern techniques. Learn about restrictive transfusion strategies and how the body manages acute anemia. Delve into the relationship between anemia and heart health, highlighting critical care strategies. Plus, uncover the fascinating adaptations of Antarctic ice fish that can survive without blood, offering unique insights into hemoglobin's role in medicine.