The Curious Clinicians

Exploring how SGLT2 inhibitors impact hemoglobin and hematocrit levels in heart failure patients, revealing surprising effects on red blood cell mass and EPO levels. Delving into the complex interplay of SGLT2 inhibitors, iron, and hemoglobin, and the significance of point of care cytosolic iron testing.

Explore why elephants have lower cancer rates, the role of the P53 protein in cancer prevention, evolutionary tumor suppressors in marine mammals, and cancer resistance in naked mole rats and Tasmanian devils.

Medical student Giancarlo Buonomo joins the podcast to discuss the complexities of systemic pulmonary vasodilators in COPD patients with pulmonary hypertension. The episode explores the impact of sildenafil, inhaled vasodilators, and supplemental oxygen therapy on blood oxygen levels and vascular functions in lung diseases.

Discover the science behind why our fingertips wrinkle in water, debunking the myth of dehydration as the cause. Explore the mechanics of water entry into the skin, the role of sweat glands and nerve system, and the evolutionary advantage of aquagenic wrinkling for grip efficiency. Learn how patients with Hansen's disease lack this ability due to nerve involvement.

In this episode from our archives, originally posted on September 16, 2020, The Curious Clinicians examined why the savory flavor umami is SO DELICIOUS. Dig in! Show notes: https://curiousclinicians.com/2020/09/16/episode-9-why-is-umami-so-delicious/ CME: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians Audio edited by Clair Morgan of Nodderly      

Exploring the physiological effects of chronic alcohol use on red blood cells, the podcast highlights macrocytosis and its correlation with alcohol consumption. They delve into the mechanisms behind red blood cell enlargement, including acetaldehyde effects, cytoskeletal changes, and electrolyte equilibrium in alcohol-related hepatitis.

Dr. Jeff Kott, a nephrology specialist, discusses phosphate binders in acute kidney injury and the usefulness of urine anion gap in non-gap metabolic acidosis. The podcast explores NephMadness 2024 and the impact of TWDFNR practices on patient care. It delves into the debate on nephrology selections, patient-centered AKI treatment options, and emphasizes informed decision-making in nephrology.

Delving into the evolutionary advantage of hereditary hemochromatosis and its link to iron regulation. Exploring the historical context and implications of HFE gene mutations on health. Examining the connection between hemochromatosis, iron accumulation, and infections like tuberculosis. Discussing how genetic variations may have influenced resistance to diseases and impacted athletic performance. Exploring the survival advantages conferred by HFE gene variants and ongoing immune-related research.

Debunking the belief of direct bacteria translocation in cirrhosis patients with SBP. Exploring the presence of intestinal bacterial overgrowth and its connection to various factors. Understanding the intricate bacterial pathway in SBP and the role of altered immunity. Emphasizing the relationship between SBP, bacteremia, and gram-negative bacteria in ascitic fluid.

The podcast explores the history and mechanisms of thalidomide, a teratogen that caused birth defects in thousands of babies. Topics covered include the development and marketing of thalidomide, the devastating impact on pregnant women, the mechanisms of thalidomide embryopathy, and the contrasting actions of individuals in drug regulation.