The Curious Clinicians

Dive into the intriguing world of hot flashes and their role in cancer treatment. Uncover the complexity of hormonal influences on reproductive health and how they contribute to these sudden temperature surges. Discover the interplay of hormones like kisspeptin and neurokinin B in women's health. Learn about the variability of hot flashes post-menopause and explore cutting-edge treatment options. Plus, ponder the evolutionary basis of these symptoms that many experience during significant life changes.

Producer Giancarlo Buonomo joins the Curious Clinicians this week to answer a morning report musing: why do we use IV PPIs to treat upper GI bleeding? Watch this episode on our new YouTube channel here, and read the show notes here! Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

Exploring the absence of steroid use in acute pancreatitis despite inflammation, with a focus on predictive tools and inflammatory markers. Evolution of IV fluid resuscitation, historical context of cortisone use, recent studies on cortisone benefits. Controversies surrounding steroids and insights on rectal endomethacin for pancreatitis treatment.

Exploring ancient antibiotic use in late antiquity African cultures, challenging traditional views of medical knowledge. Delving into the evolution of medicine from bloodletting to antibiotics, with a focus on the history of penicillin. Discussing the presence of tetracycline in ancient Nubian bones, suggesting intentional antibiotic use. Drawing parallels between ancient antibiotic practices and modern discoveries by Alexander Fleming.

Exploring how SGLT2 inhibitors impact hemoglobin and hematocrit levels in heart failure patients, revealing surprising effects on red blood cell mass and EPO levels. Delving into the complex interplay of SGLT2 inhibitors, iron, and hemoglobin, and the significance of point of care cytosolic iron testing.

Explore why elephants have lower cancer rates, the role of the P53 protein in cancer prevention, evolutionary tumor suppressors in marine mammals, and cancer resistance in naked mole rats and Tasmanian devils.

Medical student Giancarlo Buonomo joins the podcast to discuss the complexities of systemic pulmonary vasodilators in COPD patients with pulmonary hypertension. The episode explores the impact of sildenafil, inhaled vasodilators, and supplemental oxygen therapy on blood oxygen levels and vascular functions in lung diseases.

Discover the science behind why our fingertips wrinkle in water, debunking the myth of dehydration as the cause. Explore the mechanics of water entry into the skin, the role of sweat glands and nerve system, and the evolutionary advantage of aquagenic wrinkling for grip efficiency. Learn how patients with Hansen's disease lack this ability due to nerve involvement.

In this episode from our archives, originally posted on September 16, 2020, The Curious Clinicians examined why the savory flavor umami is SO DELICIOUS. Dig in! Show notes: https://curiousclinicians.com/2020/09/16/episode-9-why-is-umami-so-delicious/ CME: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians Audio edited by Clair Morgan of Nodderly      

Exploring the physiological effects of chronic alcohol use on red blood cells, the podcast highlights macrocytosis and its correlation with alcohol consumption. They delve into the mechanisms behind red blood cell enlargement, including acetaldehyde effects, cytoskeletal changes, and electrolyte equilibrium in alcohol-related hepatitis.