The Curious Clinicians cover image

The Curious Clinicians

[Archive] Tusks and Tumor Suppressors

Oct 16, 2024
Hannah Abrams, an expert in cancer biology, discusses the fascinating reasons why elephants experience significantly lower rates of cancer compared to humans. Joined by medical professional Tony Brew, they dive into the role of the P53 gene and its multiple copies in enhancing elephants' cancer resistance. The conversation touches on evolutionary biology, comparing other large mammals like whales, and the implications of this unique genetic advantage. Explore the intriguing relationship between size, genetics, and cancer across species!
31:29

Podcast summary created with Snipd AI

Quick takeaways

  • Elephants' lower cancer mortality rate, despite their size, highlights intriguing biological mechanisms that differ across species and challenge existing cancer theories.
  • The presence of multiple copies of the TP53 gene in elephants illustrates a significant genetic adaptation that enhances their ability to combat cancer.

Deep dives

The Cancer Resistance of Elephants

Elephants exhibit a lower cancer mortality rate than expected based on their size and longevity, presenting a fascinating paradox in comparative biology. While humans have cancer mortality rates between 10 and 25%, elephants have a much lower rate of approximately 4.8%. This discrepancy is particularly interesting given that larger creatures typically have more cells, which statistically increases cancer risk. The observation challenges conventional expectations and raises questions about the mechanisms behind cancer predisposition in different species.

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode