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The Curious Clinicians
92 - When the Cause is the Remedy
Jun 26, 2024
Exploring the absence of steroid use in acute pancreatitis despite inflammation, with a focus on predictive tools and inflammatory markers. Evolution of IV fluid resuscitation, historical context of cortisone use, recent studies on cortisone benefits. Controversies surrounding steroids and insights on rectal endomethacin for pancreatitis treatment.
21:48
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Quick takeaways
- Inflammatory markers predict severity in acute pancreatitis, with IL-6 indicating organ failure.
- Historical reports suggest benefits of using steroids in acute pancreatitis, but current recommendations lack their inclusion in standard care.
Deep dives
The Inflammatory Nature of Acute Pancreatitis
Acute pancreatitis is characterized by high levels of inflammation, supported by biomarkers like IL-1, IL-6, IL-8, and IL-10. Elevations in these markers, especially IL-6, not only indicate severity but also predict organ failure. Additionally, inflammatory markers like ESR, CRP, and procalcitonin are elevated in acute pancreatitis, correlating with disease severity and outcomes.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode