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The Curious Clinicians
89 - Tusks & Tumor Suppressors
May 15, 2024
Explore why elephants have lower cancer rates, the role of the P53 protein in cancer prevention, evolutionary tumor suppressors in marine mammals, and cancer resistance in naked mole rats and Tasmanian devils.
29:45
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Quick takeaways
- Elephants have evolved with multiple TP53 copies, enhancing DNA damage sensitivity and reducing cancer susceptibility.
- Naked mole rats and whales exhibit unique cancer resistance mechanisms, providing insights into cancer prevention strategies.
Deep dives
Importance of TP53 in Cancer Prevention
P53, a tumor suppressor protein encoded by the TP 53 gene, plays a crucial role in promoting apoptosis and pausing cell cycles in response to cellular stress and DNA damage. Mutations or inactivation of TP53 can lead to uncontrolled cell proliferation and cancer development. Elephants have evolved with a high number of TP53 isoforms, likely contributing to their lower cancer rates despite their large size and longevity.
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