This Week in Virology

From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer vaccine efficacy (Pfizer) Pfizer vaccine (Stat) Distribution of Pfizer vaccine (NY Times) LSTMH vaccine tracker SARS-CoV-2 humans to mink and back in Netherlands (Science) SARS-CoV-2 mink isolates in Denmark (pdf) Preexisting antibodies to SARS-CoV-2 in humans (Science) Letters read on TWiV 681 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – OSIRIS-REx | NASA Brianne – Virtual Science Museum Tours Alan – Ring Fit Adventure Rich – BUGSS Baltimore Underground Science Space Vincent – Trilobite glassworks Listener Pick Gina and Joe – COVID Fan Tutte Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guests: Mady Hornig, Fiona Lowenstein, and David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Body Politic Survivor Corps Long-haulers redefining COVID-19 (Ed Yong) I'm 26. Coronavirus sent me to the hospital (Fiona Lowenstein) We need to talk about what coronavirus recoveries look like (Fiona Lowenstein) COVID-19 long term disability (Mady Hornig, David Tuller) At 12, she's a COVID long-hauler (Davie Tuller) NICE rejects GET, Lightning Process, CBT as cure (virology blog) I want to scream (Occupy M.E.) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, Slovlakia's plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Denmark will cull mink (Reuters) State Serum Institute statement in Danish Unethical to use SARS-CoV-2 human challenge studies (PNAS) Nipah virus dynamics in bats (PNAS) Spike-mediated cardiomyocyte fusion (ResearchSquare) SARS-CoV-2 infects engineered heart tissues (bioRxiv) You cannot lock up all risks groups (Das Coronavirus) Letters read on TWiV 679 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – CNN News Amy – I voted and Grace for President Alan – The Story of More by Hope Jahren Rich – OSIRIS-REx and 101955 Bennu Vincent – The Vexed Muddler Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Nels Elde Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Zebrafish virus discovery by visualization (Curr Biol) Viral genome sequencing of White House COVID-19 outbreak (medRxiv) Genetic signature of virus that may have infected Trump (NY Times) Sixfold higher SARS-CoV-2 infection than reported in children (Med) Letters read on TWiV 678 Timestamps by Jolene. Thanks! Weekly Science Picks Kathy – Why art is important and Tagging an asteroid Rich – Vendee Globe Vincent – PrePubMed Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel's COVID-19 graph (Twitter) Cornell U containment victory (Bloomberg) Regeneron mAb trial paused (WSJ) CLIAHUB (PLoS Path) Serum antibodies to SARS-CoV-2 over time (paper one, two, three) Letters read on TWiV 677 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – Comedy Wildlife Photography Brianne – Ed Yong – Science reporting during a pandemic Alan – Tree Story by Valerie Trouet Rich – Boundless Body Radio Bethany and Casey Ruff Vincent – Wearing is Caring Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode Genome wide association study of severe COVID-19 (NEJM) Major genetic risk factor for severe COVID-19 inherited from Neanderthals (Nature) COVID-19 host genetics initiative (Eur J Hum Gen) Prolonged SARS-CoV-2 shedding in immunocompromised host (J Inf Dis) Krugman on Barrington Declaration (NY Times) Letters read on TWiV 676 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – Kids Meet a Virologist Kathy – Harvard glass marine invertebrates 3D online Rich – Chernobyl fungi Vincent – Artologica Listener Pick Justin – Totally Under Control Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege's letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode Excess COVID-19 Deaths by Age and Race and Ethnicity (MMWR) Excess COVID-19 deaths (JAMA) SARS-CoV-2 transmission (CDC) UK challenge trial (Nature) Inflammatory cytokine signature for severe COVID-19 (Nature) Death in AstraZeneca vaccine trial (Reuters) Herpetic Legion – Reactivation (YouTube) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Foege letter to Redfield (text, NPR article) False promise of herd immunity (Nature) Secret vaccine plans released (NY Times) Neuropilin-1 and SARS-CoV-2 entry (paper one, two) Letters read on TWiV 675 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – Nikon Small World Photography Competition Brianne – Modeling Herd Immunity for measles Alan – Small Gods by Terry Pratchett Rich – Boundless Body Radio Bethany and Casey Ruff Vincent – The Twenty-One Balloons by William Pene du Bois Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Med) SARS-CoV susceptibility loci in CC mice (PLoS Genetics) Combination attenuation for SARS-CoV vaccine (J Virol) Orally administered SARS-CoV-2 antiviral (Res Sq) Spike protein induces analgesia (Pain) Letters read on TWiV 674 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik Kathy – Dr. Boyd the Chemist one and two GREAT short videos one and two, How to read an old school thermometer, New Marvel storyline Wear a Mask parody of Be My Guest Rich – Clear+Vivid with Alan Alda Vincent – Immune 36: Aberrant immunity in COVID-19 Listener Pick Ryan – Dr. Fauci on politicization of pandemic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel's COVID-19 testing strategy calculator (and medRxiv preprint) US COVID-19 mortality rates (JAMA) Final remdesivir report (NEJM) Hydroxychloroquine for COVID-19 (NEJM) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Smell and taste changes as early pandemic indicators (Nat Comm) Vascular disease and thrombosis in SARS-CoV-2 infected macaques (Cell) SADS-CoV can infect human airway cells (PNAS) Letters read on TWiV 673 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – The Age of Nature Brianne – Virologist, Immunologist, Science Communicator pins and Virus Earrings Alan – Sharks, Squalene, and a SARS-CoV-2 Vaccine Rich – 6th Annual Science Mill Benefit Vincent – The Evolution of Infectious Disease by Paul Ewald Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv