This Week in Virology

Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety and immunogenicity of Russian COVID-19 vaccine (Lancet) 'Questionable' data in Russian vaccine results (Nature) Mouse model for SARS-CoV-2 ALI and mortality (Cell) Letters read on TWiV 667 Letters to Humans Timestamps by Jolene. Thanks! Weekly Science Picks Dickson - Rewilding Europe Alan - How to Do Nothing by Jenny Odell Rich - Gene drive engineered mosquitoes Vincent - TWiEVO 60 with 12 guests! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: David Brenner Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Far-UVC light inactivates viruses (paper one and two) Tips to avoid mask fogging (YouTube, article one and two) Funding for virus hunting Jonna Mazet interview (YouTube) Pandemic fake news (NY Times) Airplane SARS-CoV-2 infections (summary, article one, two, three) COVID-19: Wrong moves in wrong places (Science) Das coronavirus bullet points SARS-CoV-2 was not made in a lab (YouTube) Letters read on TWiV 666 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Increased risk for COVID-19 during pregnancy (MMWR) COVID-19 and community and close contact exposures (MMWR) COVID-19 clusters in Japan (Emerg Inf Dis) Eyeglass use associated with less COVID-19 (JAMA Ophthal) Superspreading of SARS-CoV-2 in Hong Kong (Nat Med) HKU1 HE structure and evolution (Nat Comm) Das Coronavirus summaries TWiVerse Letters read on TWiV 665 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus is mutating (Nature) Seasonal CoV immunity is short (Nat Med) Sorry, no link to the fake science document! Letters read on TWiV 664 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Young adults with COVID-19 (JAMA) Letter from Stanford professors on Atlas (pdf) National Adult and Influenza Immunization Summit Bugger, even the snapping turtles! (PLoS One) Memory B cell longevity in COVID-19 (medRxiv) Letters read on TWiV 663 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses. Host: Vincent Racaniello Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Purchase PoV 5e Volumes 1 + 2 (link) Purchase PoV 5e Volume 1 (link) Purchase PoV 5e Volume 2 (link) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Broadly neutralizing sarbecovirus mAbs (bioRxiv) Evaluation of mRNA-1273 in nonhuman primates (NEJM) Bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 (bioRxiv) Mouse-adapted SARS-CoV-2 (bioRxiv) READDI Das Coronavirus summaries in English ChAdOx1 vaccine trial halted (NY Times) Impact of high frequency screening (medRxiv) Letters read on TWiV 661 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Convalescent plasma RCT (medRxiv) Multicenter RCTs on corticosteroids for COVID-19 (JAMA) Decline of influenza B cells a year after vaccine (Science) Be ready to distribute vaccines 1 Nov (WPRI and NYTimes) EUA during COVID-19: lessons (JAMA) Not evidence for aerosol transmission (one and two) Letters read on TWiV 660 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Christian previously on TWiV 601 Plague percolation phenomenon (Nature) TMPRSS2 inhibitor for SARS-CoV-2 (Cell) Repeated infections with endemic CoV (J Inf Dis) Koch Institute SARS-CoV-2 reports Letters read on TWiV 659 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CDC told to soften SARS-CoV-2 testing guidelines (NYTimes) Moderna investor presentation on mRNA-1273 vaccine (link) SARS-CoV-2 reinfection (Clin Inf Dis) Dr. Fauci talks with just about anyone (NYTimes) Letters read on TWiV 658 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv