This Week in Virology

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ahead of the Curve by Shane Crotty SARS-CoV-2 T cell epitopes (Cell) Cross-reactive CoV T cell epitopes (Science) Knowns and unknowns about SARS-CoV-2 immunity (Nat Rev Imm) Letters read on TWiV 657 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Racial and ethnic disparities in workplace COVID-19 (CDC) Rescission of guidances on laboratory tests (FDA) EUA on convalescent plasma on hold (NY Times) Letters read on TWiV 656 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Robert Fullilove Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)<>Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Health of racial and ethnic minority groups (CDC) COVID-19 death/hospitalization by race/ethnicity (CDC) Racial and ethnic disparities in workplace COVID-19 (CDC) SalivaDirect EUA (FDA) Adenovirus vectored SARS-CoV-2 experimental vaccine protects mice (Nat Comm) Letters read on TWiV 655 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Daniel's recommendations for COVID-19 testing (pdf) Effects of convalescent plasma on COVID-19 (medRxiv) ESCV virtual meeting on COVID-19 The Russian Vaccine (In The Pipeline) Russia's vaccine approval (Science) Letters read on TWiV 654 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic. Hosts: Vincent Racaniello and Rich Condit Guests: Alfonso Landeros, Ken Lange, Mary E. Sehl, and Janet Sinsheimer Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode School reopening strategies (medRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Adam Kucharski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The Rules of Contagion (Amazon affiliate link) Overdispersion in SARS-CoV-2 transmission (Wellcome Open Res) Sorrento Therapeutics test In vitro diagnostics EUAs (FDA) Letters read on TWiV 652 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Denise Esposito Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Template for at-home, OTC diagnostic tests (FDA) Postdoctoral position in Prasad laboratory (pdf) Rapidtests.org Masks are cool, Miasma t-shirts (CafePress) Letters read on TWiV 651 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travis County indicators dashboard SARS-CoV-2 transmission at an overnight camp (MMWR) Adaptation of SARS-CoV-2 in mice (Science) Acute SARS-CoV-2 infection impairs DC and T cell responses (Imm) Boulder, Columbia, Illinois rapid saliva tests Letter drafts for $1 testing Letters read on TWiV 650 Timestamps by Jolene. Thanks! Weekly Science Picks KathyBBC Witness History, Maurice Hilleman 9 minute audio (quotes by Paul Offit) "The fastest vaccine ever developed"And APOD Picture Rocks Sun Dagger Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses. Host: Vincent Racaniello Guests: Shan-Lu Liu, David Bisaro, Amanda Panfill, Mark Peeples, Matt Sullivan, Chris Walker, Qiuhong Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New virus requires international control (Nature) TIM-family proteins inhibit HIV-1 release (PNAS) Designing a HCV vaccine (Curr Op Virol) Attenuated vaccines for RSV in children (J Inf Dis) Plant histone reader suppresses geminivirus infection (J Virol) HTLV-associated malignancy (Curr Op Virol) Coronaviruses in pigs (Curr Op Virol) Marine DNA viral diversity pole to pole (Cell) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Roche trial of Actemra for COVID-19 fails (Reuters) Postdoctoral position at RML Shedding of SARS-CoV-2 at different ages (JAMA Ped) Evolutionary origins of SARS-CoV-2 (Nat Microbio) Letters read on TWiV 648 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv