This Week in Virology

Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Ari Kozik and Kishana Taylor Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Black microbiologists push for visibility (NY Times) Black in Microbiology keynotes (YouTube) Black in Microbiology Black in Neuro AstroKate rides again (and on TWiV 444) COVID-19 testing strategy calculator (and medRxiv preprint) Pause of J&J vaccine trial (STAT) Pause of Lilly mAb trial (NY Times) REGN-CoV-2 mAbs in animals (Science) Regeneron investor slides on mAb phase 3 SARS-CoV-2 reinfection in US (Lancet Inf Dis) Letters read on TWiV 672 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - A Lab of One's Own by Rita Colwell Kathy – Endonym map Rich - "The Coronavirus Unveiled" by Carl Zimmer Vincent - Principles of Virology 5th Edition Listener Pick Les - Coronavirus cake Mary - Choir finds a way to sing Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASH guidelines on anticoagulants in COVID-19 patients (ASH) Followup of adults with noncritical COVID-19 (Clin Micr Inf) Tocilizumab in COVID-19 ICU patients (Lancet Rheum) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders 2020 Nobel Prize Chemistry (pdf) Progress towards polio eradication Afghanistan (MMWR) Inborn errors of IFN and serious COVID-19 (Science) Letters read on TWiV 671 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts Alan - Lost Prologue Rich -RAPS COVID-19 vaccine tracker Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Kizzmekia Corbett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pre-fusion structure of CoV spike (Nature) Pre-fusion structure of SARS-CoV-2 spike (Science) Evaluation of mRNA-1273 in nonhuman primates (NEJM) SARS-CoV-2 vaccine from pandemic preparedness (Nature) Nanoparticulate universal influenza vaccine from stem antigens (mBio) Biological safety officer position at Columbia U Medicine Nobel Prize for Hepatitis C virus (pdf) Alter's work on non-A non-B hepatitis (paper one, paper two) Houghton: single clone of HCV genome (Science) Rice: Transmission of hepatitis C to chimpanzee (Science) Charlie Rice on TWiV 392 Chemistry Nobel Prize to Doudna and Charpentier (Nobel.org) FDA releases stricter guidelines for COVID-19 vaccines (NY Times, FDA pdf) Bullet points of Das coronavirus Recovery of 1918 influenza virus stories (one, two) Letters read on TWiV 670 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - COVID-19 in Molecular Detail for Teaching Kathy – Mars shining brightest since 2003 Rich - Lost Prologue Vincent - Girl from Ipanema is weirder than you thought Listener Pick Sandra - Learn Medical Research Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Rethinking COVID-19 test sensitivity (NEJM) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Vitamin D and COVID-19 (Lancet Diabet Endocrin) J&S Ad26 SARS-CoV-2 vaccine phase 1/2a results (medRxiv) All the wrong moves (Science Signaling) Trump main drive of CoV misinformation (NYTimes) Surgisphere scandal (The Scientist) SARS-CoV-2 D614G earlier transmission in vivo (bioRxiv) Das Coronavirus bullet points Letters read on TWiV Timestamps by Jolene. Thanks! Weekly Science Picks Dickson - Why we should all wear masks Brianne - Milestones in Vaccines Rich - Wallpaper/fabric designs by David Goodsell Vincent - Das Coronavirus bullet points and a new t-shirt Listener Pick Justin - COVID Alert NY App | Department of Health Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Tony Schountz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 infection of deer mice (bioRxiv) Infection of Jamaican fruit bats with MERS-CoV (Sci Rep) Immunological control of virus infections in bats (Front Immunol) Transmission of bat influenza viruses in bats (Nat Micro) Letters read on TWiV 668 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Virus Masks Kathy – UV in the vineyards (video) Rich - Great White Shark Attack Vincent - Smart WiFi garage door opener Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety and immunogenicity of Russian COVID-19 vaccine (Lancet) 'Questionable' data in Russian vaccine results (Nature) Mouse model for SARS-CoV-2 ALI and mortality (Cell) Letters read on TWiV 667 Letters to Humans Timestamps by Jolene. Thanks! Weekly Science Picks Dickson - Rewilding Europe Alan - How to Do Nothing by Jenny Odell Rich - Gene drive engineered mosquitoes Vincent - TWiEVO 60 with 12 guests! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: David Brenner Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Far-UVC light inactivates viruses (paper one and two) Tips to avoid mask fogging (YouTube, article one and two) Funding for virus hunting Jonna Mazet interview (YouTube) Pandemic fake news (NY Times) Airplane SARS-CoV-2 infections (summary, article one, two, three) COVID-19: Wrong moves in wrong places (Science) Das coronavirus bullet points SARS-CoV-2 was not made in a lab (YouTube) Letters read on TWiV 666 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Increased risk for COVID-19 during pregnancy (MMWR) COVID-19 and community and close contact exposures (MMWR) COVID-19 clusters in Japan (Emerg Inf Dis) Eyeglass use associated with less COVID-19 (JAMA Ophthal) Superspreading of SARS-CoV-2 in Hong Kong (Nat Med) HKU1 HE structure and evolution (Nat Comm) Das Coronavirus summaries TWiVerse Letters read on TWiV 665 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus is mutating (Nature) Seasonal CoV immunity is short (Nat Med) Sorry, no link to the fake science document! Letters read on TWiV 664 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv