This Week in Virology

In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children do transmit infection (Emerg Inf Dis) NIH RADx initiative (NEJM) Rockefeller Foundation testing plan HCQ observational study (Int J Inf Dis) Can't kill HCQ (Science Based Medicine) HCQ does not inhibit SARS-CoV-2 in human lung cells (Nature) HCQ does not inhibit SARS-CoV-2 in nonhuman primates (Nature) Shut-down to stop SARS-CoV-2 (WaPo) Racine firefighters doing LAMP (Wired) LAMP (video, webinar, paper 1, paper 2) Letter drafts for $1 testing Letters read on TWiV 647 Timestamps by Jolene. Thanks! Weekly Science Picks Kathy - Vertical Farms Fill a Tall Order by Dickson Despommier and APOD Rich - Mars in 4K LIstener Pick Christiane - ZSK - Ich habe Besseres zu tun (Official Video) Drosten Jon - The Logic of Doomsday Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses. Hosts: Vincent Racaniello and Rich Condit Guest: Eugene Koonin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Virocentricity with Eugene Koonin (TWiV 275) Origin of viruses (Nat Rev) Multiple origins of capsid proteins from cells (PNAS) Origins and evolution of global RNA virome (mBio) Evolution of NCLDV of eukaryotes (Adv Virus Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode State Dept. memo on Wuhan BSL-4 lab (pdf) Biosafety levels (Wikipedia) Inside a BSL-4 (TWiV) From people to panthers (bioRxiv) Letters read on TWiV 645 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to play Download TWiV 644 (69 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode US COVID-19 cases (NY Times) Identify flawed research before it is dangerous (NY Times) Mask up, America! (NY Times) $1.95 billion to Pfizer (NY Times) Phase I trial of Pfizer mRNA vaccine (medRxiv) Phase I/II trial of ChAdOx1 vaccine (Lancet) Rockefeller Foundation testing plan TWiV 640 on MedCram Letter drafts for $1 testing Letters read on TWiV 644 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses. Hosts: Vincent Racaniello and Rich Condit Guest: Bernie Moss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Link for this episode Reflections on Bernie Moss' career (JBC) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travis County virtual Town Hall SARS-CoV-2 mRNA vaccine, preliminary results (NEJM) Factors associated with COVID-19 death (Nature) Letters read on TWiV 642 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness. Hosts: Vincent Racaniello and Rich Condit Guest: Dr. Anthony Fauci Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Dr. Fauci was previously on TWiV 219 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Michael Mina Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Michael Mina on Immune 26 White House bypasses CDC (NY Times) Test sensitivity is secondary to frequency and turnaround time (medRxiv) Group testing for SARS-CoV-2 (medRxiv) Consider the cycle threshold value (Clin Inf Dis) MERS-CoV spike nanoparticles protect mice from infection (Vaccine) CoV spike protein nanoparticles induce neutralizing antibodies in mice (Vaccine) Letters read on TWiV 640 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV-1, human papillomaviruses and much more. Host: Vincent Racaniello Guest: Erling Norrby Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Nobel Prizes and Life Sciences by Erling Norrby Nobel Prizes and Nature's Surprises by Erling Norrby Nobel Prizes and Notable Discoveries by Erling Norrby Nobel Prizes: Cancer, Vision and the Genetic Code by Erling Norrby Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guests: Viviana Simon, Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Serological assay for SARS-CoV-2 infection (Nat Med) Early spread of SARS-CoV-2 in NYC (Science) Seroconversion of a city (medRxiv) Immune response and PCR positivity of NYC cohort (medRxiv) Letters read on TWiV 638 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv