This Week in Virology

Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Young adults with COVID-19 (JAMA) Letter from Stanford professors on Atlas (pdf) National Adult and Influenza Immunization Summit Bugger, even the snapping turtles! (PLoS One) Memory B cell longevity in COVID-19 (medRxiv) Letters read on TWiV 663 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses. Host: Vincent Racaniello Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Purchase PoV 5e Volumes 1 + 2 (link) Purchase PoV 5e Volume 1 (link) Purchase PoV 5e Volume 2 (link) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Broadly neutralizing sarbecovirus mAbs (bioRxiv) Evaluation of mRNA-1273 in nonhuman primates (NEJM) Bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 (bioRxiv) Mouse-adapted SARS-CoV-2 (bioRxiv) READDI Das Coronavirus summaries in English ChAdOx1 vaccine trial halted (NY Times) Impact of high frequency screening (medRxiv) Letters read on TWiV 661 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Convalescent plasma RCT (medRxiv) Multicenter RCTs on corticosteroids for COVID-19 (JAMA) Decline of influenza B cells a year after vaccine (Science) Be ready to distribute vaccines 1 Nov (WPRI and NYTimes) EUA during COVID-19: lessons (JAMA) Not evidence for aerosol transmission (one and two) Letters read on TWiV 660 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Christian previously on TWiV 601 Plague percolation phenomenon (Nature) TMPRSS2 inhibitor for SARS-CoV-2 (Cell) Repeated infections with endemic CoV (J Inf Dis) Koch Institute SARS-CoV-2 reports Letters read on TWiV 659 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CDC told to soften SARS-CoV-2 testing guidelines (NYTimes) Moderna investor presentation on mRNA-1273 vaccine (link) SARS-CoV-2 reinfection (Clin Inf Dis) Dr. Fauci talks with just about anyone (NYTimes) Letters read on TWiV 658 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ahead of the Curve by Shane Crotty SARS-CoV-2 T cell epitopes (Cell) Cross-reactive CoV T cell epitopes (Science) Knowns and unknowns about SARS-CoV-2 immunity (Nat Rev Imm) Letters read on TWiV 657 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Racial and ethnic disparities in workplace COVID-19 (CDC) Rescission of guidances on laboratory tests (FDA) EUA on convalescent plasma on hold (NY Times) Letters read on TWiV 656 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Robert Fullilove Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)<>Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Health of racial and ethnic minority groups (CDC) COVID-19 death/hospitalization by race/ethnicity (CDC) Racial and ethnic disparities in workplace COVID-19 (CDC) SalivaDirect EUA (FDA) Adenovirus vectored SARS-CoV-2 experimental vaccine protects mice (Nat Comm) Letters read on TWiV 655 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Daniel's recommendations for COVID-19 testing (pdf) Effects of convalescent plasma on COVID-19 (medRxiv) ESCV virtual meeting on COVID-19 The Russian Vaccine (In The Pipeline) Russia's vaccine approval (Science) Letters read on TWiV 654 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv