This Week in Virology

In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China approves COVID-19 vaccine for military (CNN) Ad5-vectored COVID-19 vaccine phase I results (Lancet) US pays $1.6 billion for Novavax vaccine (NY Times) CEPI awards $388 million to Novavax (Novavax) HHS on Novavax vaccine (HHS) Novavax phase I/II trials (GlobeNewswire) Prevalence of SARS-CoV-2 in Spain (Lancet) Shedding and transmissibility of SARS-CoV-2 (Nature) Letters read on TWiV 637 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development. Host: Vincent Racaniello Guests: Chris Basler, Andrew Gewirtz, Priya Luthra, and Richard Plemper Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mutant Ebolavirus lacks virulence (Cell Rep) Blocking Ebolavirus replication by depleting nucleoside pools (Antiviral Res) Herd immunity against bad actor molecules (PloS Path) Bacteria prevent and cure rotavirus infection (Cell) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectious SARS-CoV-2 in nasopharynx of youth (Emerg Inf Dis) SARS-CoV-2 viral load by patient age (Hosp Charité) Viral load in children with COVID-19 (Emerg Inf Dis) Role of children in SARS-CoV-2 transmission (virology blog) Letters read on TWiV 635 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New swine flu with pandemic potential (BBC, PNAS) Oral SARS-CoV-2 vaccine candidate (ClinicalOmics) Operation Warp Speed (HHS) ACTIV (NIH) Development and licensure of COVID-19 vaccines (FDA) Letters read on TWiV 634 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host: Vincent Racaniello Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dengue virus and endothelial permeability (J Clin Invest) Dengue virus morphological switch (PLoS Path) Symptomatic yellow fever vaccine infections (Nat Med) RNA recognition by RIG-I and MDA5 (Nucl Acids Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dexamethasone for COVID-19 (medRxiv) Proning trial for COVID-19 (Lancet) Tocilizumab for COVID-19 cytokine storm (Chest) Global causes of death Vesicular stomatitis in horses (ProMedMail) Daily tests needed (Atlantic) SARS-CoV-2 infection risks Letters read on TWiV 632 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Probability of symptoms and severe COVID-19 (aRxiv) Cellular immune response without seroconversion (medRxiv) Image credit Letters read on TWiV 631 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission. Host: Vincent Racaniello Guest: Lee Ching Ng Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!

Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dexamethasone reduces COVID-19 deaths (U Oxford) Assessment of asymptomatic COVID-19 (Nature Med) Age-dependent effects on SARS-CoV-2 transmission (Nature Med) Image credit Letters read on TWiV 629 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Austin TX key indicators for staging D614 amino acid change (Scripps) Virus shedding in hospitalized patients (medRxiv) Hamster SARS-CoV-2 model (Nature) COVID-19 host genetic initiative Image credit Letters read on TWiV 628 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv