In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Links for this episode

Genome wide association study of severe COVID-19 (NEJM)
Major genetic risk factor for severe COVID-19 inherited from Neanderthals (Nature)
COVID-19 host genetics initiative (Eur J Hum Gen)
Prolonged SARS-CoV-2 shedding in immunocompromised host (J Inf Dis)
Krugman on Barrington Declaration (NY Times)
Letters read on TWiV 676
Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 676: Tragic gene flow from Neanderthals