This Week in Virology

Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mitigation strategies in early care and education settings (MMWR) WHO solidarity trial results (NEJM) Letters read on TWiV 692 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Laura Splan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Laura Splan website BSL-3 Assistant Manager position MMR titers in recovered COVID-19 patients (mBio) Ivermectin and SARS-CoV-2 (TWiV 599) Treatment of COVID-19 with ivermectin (Int J Inf Dis) Ivermectin approved dosing (Mayo Clinic) Briefing document for Pfizer vaccine (FDA) Vaccinated? Wear a mask (NY Times) Efficacy of ChAdOx1 vaccine (Lancet) Mix & Match Pfizer & Oxford jabs (Times Long) SARS-CoV-2 seroprevalence in Seattle (medRxiv) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Patterns for Virus snowflakes Kathy – 2020 Nobel Prize lectures (hepatitis C) (link to all and concert) Historical review by Harvey Alter Rich – New Data Confirm 2020 SO is Upper Centaur Rocket Booster from 1960's (Wiki) Vincent – The Right Stuff Listener Pick Miikael – Tiny tweak behind COVID-19 vaccines Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NYC will create pandemic response institute (NY Bus J) Comparison of ACE2 in vertebrates (PNAS) Olfactory transmucosal invasion of CNS by SARS-CoV-2 (Nat Neurosci) Letters read on TWiV 690 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – National Geographic best animal photos of 2020 Amy – American Contagions: Epidemics and the law from Smallpox to COVID-19 by John Fabian Witt Alan – HamSCI citizen science organization Rich – DeepMind's AI makes gigantic leap in solving protein structures Vincent – Army Ants: Nature's Ultimate Social Hunters by Daniel Kronauer Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vitamin D levels in COVID-19 patients (Nature) ACIP recommendations for distribution of COVID-19 vaccine (MMWR) Updated CDC guidance on when to quarantine (CDC) Letters read on TWiV 689 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 688: We put COVID-19 papers through a sieve December 2, 2020 On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode UK grants EUA for Pfizer vaccine (NY Times) ACIP advice on who to vaccinate first (NY Times) Das coronavirus update SARS-CoV-2 protease regulates innate response (Nature) Viral mRNAs do not indicate viral replication (Nat Comm) Addendum to SARS-CoV-2 discovery paper (Nature) 16:15 SARS-CoV-2 mRNA vaccine and GC formation (Immunity) 29:35 What scientists say about masks (NY Times) 1:29:03 Letters read on TWiV 688 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Pedromics Kathy – Global map at Mars opposition Rich – Janeway's Immunobiology Vincent – Janet Iwasa's Animation Lab Listener Pick Cheryl – BioRender.com holiday card templates Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Peter Hotez Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Peter Hotez on TWiP 29 and TWiV Special Wednesday, January 20, 2021 (Microbes Inf) SARS-CoV-2 RBD protein vaccine candidate (bioRxiv) Anti-science extremism in America (Microbes Inf) Low cost accessible COVID-19 vaccine (PLoS NTD) Letters read on TWiV 687 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – The World's First Energy-Positive Hotel to Open in Norway Brianne – The Food Lab: Better Home Cooking Through Science Alan – ACIP's ethical principles for COVID-19 vaccine allocation Rich – The Mandolorian Vincent – T. rex and the Crater of Doom by Walter Alvarez Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron's monoclonal antibody and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO Solidarity trial for Remdesivir and other drugs (medRxiv) EUA for Baricitinib (FDA) EUA for Casirivimab and Imdevimab (FDA) RCT: No benefit of convalescent plasma (NEJM) Letters read on TWiV 686 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode AZD1222 vaccine efficacy (AstraZeneca) Addendum to SARS-CoV-2 discovery paper (Nature) SARS-CoV-2 mRNA vaccine and GC formation (Immunity) What scientists say about masks (NY Times) Letters read on TWiV 685 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Types of Scientists Coloring Book Kathy – South Pole video Rich – Steve Jobs by Walter Isaacson Vincent – Screenology (I interviewed Deb Sklut here) Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes Lucira mini home testing kit (FDA) 60 day outcomes of COVID-19 patients (Annals Int Med) Immunological memory to SARS-CoV-2 infection at 6 months (bioRxiv) Letters read on TWiV 684 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – Benoit Mandlebrot's 96 birthday Brianne – #BlackinImmunoWeek Rich – GoISSWatch ISS Tracking; Spot The Station (NASA) Vincent – Microbes Rule Listener Pick Agda – Sandwalk Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy of Moderna and Pfizer mRNA vaccines Longer shelf life of Moderna vaccine (Moderna) Prothrombotic antibodies in COVID-19 serum (Sci Trans Med) Where is SARS-CoV-2 in the human body? (PLoS Path) Letters read on TWiV 683 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Picture a Scientist Kathy – Colors of the Moon and Word that hasn't changed Rich – NASA YouTube channel Vincent – Laura Splan science art Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv