This Week in Virology

In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode Genome wide association study of severe COVID-19 (NEJM) Major genetic risk factor for severe COVID-19 inherited from Neanderthals (Nature) COVID-19 host genetics initiative (Eur J Hum Gen) Prolonged SARS-CoV-2 shedding in immunocompromised host (J Inf Dis) Krugman on Barrington Declaration (NY Times) Letters read on TWiV 676 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – Kids Meet a Virologist Kathy – Harvard glass marine invertebrates 3D online Rich – Chernobyl fungi Vincent – Artologica Listener Pick Justin – Totally Under Control Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege's letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode Excess COVID-19 Deaths by Age and Race and Ethnicity (MMWR) Excess COVID-19 deaths (JAMA) SARS-CoV-2 transmission (CDC) UK challenge trial (Nature) Inflammatory cytokine signature for severe COVID-19 (Nature) Death in AstraZeneca vaccine trial (Reuters) Herpetic Legion – Reactivation (YouTube) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Foege letter to Redfield (text, NPR article) False promise of herd immunity (Nature) Secret vaccine plans released (NY Times) Neuropilin-1 and SARS-CoV-2 entry (paper one, two) Letters read on TWiV 675 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – Nikon Small World Photography Competition Brianne – Modeling Herd Immunity for measles Alan – Small Gods by Terry Pratchett Rich – Boundless Body Radio Bethany and Casey Ruff Vincent – The Twenty-One Balloons by William Pene du Bois Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Med) SARS-CoV susceptibility loci in CC mice (PLoS Genetics) Combination attenuation for SARS-CoV vaccine (J Virol) Orally administered SARS-CoV-2 antiviral (Res Sq) Spike protein induces analgesia (Pain) Letters read on TWiV 674 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik Kathy – Dr. Boyd the Chemist one and two GREAT short videos one and two, How to read an old school thermometer, New Marvel storyline Wear a Mask parody of Be My Guest Rich – Clear+Vivid with Alan Alda Vincent – Immune 36: Aberrant immunity in COVID-19 Listener Pick Ryan – Dr. Fauci on politicization of pandemic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel's COVID-19 testing strategy calculator (and medRxiv preprint) US COVID-19 mortality rates (JAMA) Final remdesivir report (NEJM) Hydroxychloroquine for COVID-19 (NEJM) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Smell and taste changes as early pandemic indicators (Nat Comm) Vascular disease and thrombosis in SARS-CoV-2 infected macaques (Cell) SADS-CoV can infect human airway cells (PNAS) Letters read on TWiV 673 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – The Age of Nature Brianne – Virologist, Immunologist, Science Communicator pins and Virus Earrings Alan – Sharks, Squalene, and a SARS-CoV-2 Vaccine Rich – 6th Annual Science Mill Benefit Vincent – The Evolution of Infectious Disease by Paul Ewald Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Ari Kozik and Kishana Taylor Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Black microbiologists push for visibility (NY Times) Black in Microbiology keynotes (YouTube) Black in Microbiology Black in Neuro AstroKate rides again (and on TWiV 444) COVID-19 testing strategy calculator (and medRxiv preprint) Pause of J&J vaccine trial (STAT) Pause of Lilly mAb trial (NY Times) REGN-CoV-2 mAbs in animals (Science) Regeneron investor slides on mAb phase 3 SARS-CoV-2 reinfection in US (Lancet Inf Dis) Letters read on TWiV 672 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - A Lab of One's Own by Rita Colwell Kathy – Endonym map Rich - "The Coronavirus Unveiled" by Carl Zimmer Vincent - Principles of Virology 5th Edition Listener Pick Les - Coronavirus cake Mary - Choir finds a way to sing Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASH guidelines on anticoagulants in COVID-19 patients (ASH) Followup of adults with noncritical COVID-19 (Clin Micr Inf) Tocilizumab in COVID-19 ICU patients (Lancet Rheum) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders 2020 Nobel Prize Chemistry (pdf) Progress towards polio eradication Afghanistan (MMWR) Inborn errors of IFN and serious COVID-19 (Science) Letters read on TWiV 671 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts Alan - Lost Prologue Rich -RAPS COVID-19 vaccine tracker Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Kizzmekia Corbett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pre-fusion structure of CoV spike (Nature) Pre-fusion structure of SARS-CoV-2 spike (Science) Evaluation of mRNA-1273 in nonhuman primates (NEJM) SARS-CoV-2 vaccine from pandemic preparedness (Nature) Nanoparticulate universal influenza vaccine from stem antigens (mBio) Biological safety officer position at Columbia U Medicine Nobel Prize for Hepatitis C virus (pdf) Alter's work on non-A non-B hepatitis (paper one, paper two) Houghton: single clone of HCV genome (Science) Rice: Transmission of hepatitis C to chimpanzee (Science) Charlie Rice on TWiV 392 Chemistry Nobel Prize to Doudna and Charpentier (Nobel.org) FDA releases stricter guidelines for COVID-19 vaccines (NY Times, FDA pdf) Bullet points of Das coronavirus Recovery of 1918 influenza virus stories (one, two) Letters read on TWiV 670 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - COVID-19 in Molecular Detail for Teaching Kathy – Mars shining brightest since 2003 Rich - Lost Prologue Vincent - Girl from Ipanema is weirder than you thought Listener Pick Sandra - Learn Medical Research Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Rethinking COVID-19 test sensitivity (NEJM) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Vitamin D and COVID-19 (Lancet Diabet Endocrin) J&S Ad26 SARS-CoV-2 vaccine phase 1/2a results (medRxiv) All the wrong moves (Science Signaling) Trump main drive of CoV misinformation (NYTimes) Surgisphere scandal (The Scientist) SARS-CoV-2 D614G earlier transmission in vivo (bioRxiv) Das Coronavirus bullet points Letters read on TWiV Timestamps by Jolene. Thanks! Weekly Science Picks Dickson - Why we should all wear masks Brianne - Milestones in Vaccines Rich - Wallpaper/fabric designs by David Goodsell Vincent - Das Coronavirus bullet points and a new t-shirt Listener Pick Justin - COVID Alert NY App | Department of Health Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Tony Schountz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 infection of deer mice (bioRxiv) Infection of Jamaican fruit bats with MERS-CoV (Sci Rep) Immunological control of virus infections in bats (Front Immunol) Transmission of bat influenza viruses in bats (Nat Micro) Letters read on TWiV 668 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Virus Masks Kathy – UV in the vineyards (video) Rich - Great White Shark Attack Vincent - Smart WiFi garage door opener Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv