This Week in Virology

In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with extended duration Nirmatrelvir/Ritonavir, anemia as a risk factor for disease progression in patients admitted for COVID-19, impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome, post-COVID condition in patients with inflammatory rheumatic diseases, outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months, metformin reduces SARS-CoV-2 in a Phase 3 randomized placebo controlled clinical trial, persistent serum protein signatures define an inflammatory subcategory of long COVID, and the relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Surveillance to track progress toward poliomyelitis eradication (CDC) Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3 (Nature) Evaluation of Oseltamivir to prevent hospitalization in outpatients with Influenza (JAMA) Viral emissions into air and environment after SARS-CoV-2 human challenge (The Lancet) Has COVID-19 threatened routine childhood vaccination (Health Affairs) Successful treatment of COVID-19 with extended duration Nirmatrelvir/Ritonavir (OFID) Anemia as a risk factor for disease progression in patients admitted for COVID-19 (Nature) Impact of fatigue as the determinant of functional limitations among patients with post-COVID-19 syndrome (BMJ) Post-COVID condition in patients with inflammatory rheumatic diseases (The Lancet) Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition (The Lancet) Metformin reduces SARS-CoV-2 in a Phase 3 placebo controlled clinical trial (MedRxiv) Persistent serum protein define an inflammatory subcategory of long COVID (Nature) Relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome (JTM) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1016 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent and Rich travel to Ft. Detrick to visit USAMRIID and speak with Todd, Crystal, John and Jay about their careers, their research, and the mission of the US Army Medical Institute of Infectious Diseases. Host: Vincent Racaniello and Rich Condit Guests: Todd Bell, Crystal Burke, John Dye, and Jay Hooper Opinions, interpretations, conclusions, and recommendations are those of the panelists and no official endorsement by the U.S. Army should be inferred. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server USAMRIID Mpox virus in testes of nonhuman primates (Nat Micro) Efficacy of equine encephalitis virus-like particle vaccine (Viruses) Prophylaxis with SARS-CoV-2 mAb (Antimicrob Agents Chemother) Needle-free jet injection of DNA vaccine (PLoS One) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses estimates of SARS-CoV-2 seroprevalence and incidence of primary SARS-CoV-2 infections among blood donors, by COVID-19 vaccination status, smart thermometer–based participatory surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic, COVID-19 vaccine mandates, changing severity and epidemiology of adults hospitalized with COVID-19 in the United States after introduction of COVID-19 vaccines, effectiveness of COVID-19 treatment with Nirmatrelvir–Ritonavir or Molnupiravir among U.S. veterans, national trends in anticoagulation therapy for COVID-19 hospitalized adults in the United States, development of a definition of postacute sequelae of SARS-CoV-2 infection, neuroinflammation after COVID-19 with persistent depressive and cognitive symptoms, long COVID clinical phenotypes up to six months after infection identified by latent class analysis of self-reported symptoms, and coronary microvascular health in symptomatic patients with prior COVID-19 infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Estimates of SARS-CoV-2 seroprevalence and incidence of infections among blood donors, by vaccination status (CDC) Smart thermometer–based surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic (JAMA) COVID-19 vaccine mandates (GOV) Changing epidemiology of adults hospitalized with COVID-19 after introduction of vaccines (CID) Effectiveness of COVID-19 treatment with Nirmatrelvir–Ritonavir or Molnupiravir among U.S. Veterans (ACP Journals) National trends in Anticoagulation therapy for COVID-19 (IDSA) Development of a definition of postacute sequelae of SARS-CoV-2 infection (JAMA) Neuroinflammation after COVID-19 with depressive and cognitive symptoms (JAMA) Long COVID clinical phenotypes up to six months after infection identified by latent class analysis of self-reported symptoms (OFID) Coronary microvascular health in patients with prior COVID-19 infection (EACVI) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1014 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Register for ASV 2023 Research assistant position at FDA (pdf) MicrobeTV Discord Server Avian influenza H5N1 (Eurosurveillance) Pan-influenza NA antibody (Nature) World Animal Health Information System Timestamps by Jolene. Thanks! Weekly Picks Angela – May's best science images – Nature Kathy – Historical reasons for resistance to recognizing airborne transmission Rich – Scan of Titanic reveals wreck as never seen before – BBC News Alan – Science Education in an Age of Misinformation Vincent – Equity, Diversity and Inclusion: When communication all changed Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer's PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, development of a definition of postacute sequelae of SARS-CoV-2 infection, COVID-19 and risk for mental disorders among adults in Denmark, risk of new post-COVID mental disorders higher only in older patients. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Potential for recurrent Mpox outbreaks among men who have sex with men (CDC) Association between SARS-CoV-2 variants and frequency of acute symptoms (OFID) Key correlates for household transmission of SARS-CoV-2 (OFID) PAXLOVID receiving FDA approval for patients at high risk of severe COVID-19 (Pfizer) Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients with COVID-19 (The Lancet) Development of a definition of postacute sequelae of SARS-CoV-2 (JAMA) COVID-19 and risk for mental disorders among adults in Denmark (JAMA) Risk of new post-COVID mental disorders higher only in older patients (CIDRAP) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1012 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities. Host: Vincent Racaniello Guests: Frank Aylward and Jed Fuhrman Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server 11th Aquatic Virus Workshop Endogenization of giant virus genomes in green algae (Nature) Red Queen dynamics in marine viruses (Nature) Biogeography of marine giant viruses (ISME Commun) Marine prokaryotic community structure (Nat Commun) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode HIV surveillance report (CDC) FDA voted in favor of approving Abrysvo vaccine (Pfizer) Canine olfactory detection of SARS-CoV-2-infected humans (Annals of Epidemiology) Safety of the BNT162b2 COVID-19 vaccine in children (JAMA) Statement on the antigen composition of COVID-19 vaccines (WHO) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1010 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne. Host: Vincent Racaniello Guests: Kanta Subbarao and Maria von Kerkhove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Nidovirus Symposium, Montreux WHO Collaborating Centre for Influenza, Melbourne Maria von Kerkhove (Wikipedia) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Virus variant clinical performance of a SARS-CoV-2 rapid antigen test (CID) Ventilation in buildings (CDC) COVID-19 mortality among SSRI users (CMI) Risk of post-acute sequelae of SARS-CoV-2 infection associated with sleep apnea (SLEEP) Trajectories of the evolution of post COVID-19 condition (IJID) Efficacy of cognitive behavioral therapy targeting fatigue following COVID-19 (CAD) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1008 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Register for ASV 2023 Research assistant position at FDA (pdf) MicrobeTV Discord Server nOPV2 after two years (Polioeradication) Raccoon distemper in Toronto (CityNews Everywhere) NIH reinstates EcoHealth grant (Nature) Chromosomal breakage by EBNA1 (Nature) Agent of chromosomal instability (Nature) Timestamps by Jolene. Thanks! Weekly Picks Angela – Night Science Kathy – Kermit, Jim Henson, Rainbow Connection Rich – Alexander Skarsgård Explains the Answer to Everything Vincent – Beyond the Noise with Dr. Paul Offit Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv