TWiV 1016: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with extended duration Nirmatrelvir/Ritonavir, anemia as a risk factor for disease progression in patients admitted for COVID-19, impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome, post-COVID condition in patients with inflammatory rheumatic diseases, outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months, metformin reduces SARS-CoV-2 in a Phase 3 randomized placebo controlled clinical trial, persistent serum protein signatures define an inflammatory subcategory of long COVID, and the relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome.

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Links for this episode

• Surveillance to track progress toward poliomyelitis eradication (CDC)
• Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3 (Nature)
• Evaluation of Oseltamivir to prevent hospitalization in outpatients with Influenza (JAMA)
• Viral emissions into air and environment after SARS-CoV-2 human challenge (The Lancet)
• Has COVID-19 threatened routine childhood vaccination (Health Affairs)
• Successful treatment of COVID-19 with extended duration Nirmatrelvir/Ritonavir (OFID)
• Anemia as a risk factor for disease progression in patients admitted for COVID-19 (Nature)
• Impact of fatigue as the determinant of functional limitations among patients with post-COVID-19 syndrome (BMJ)
• Post-COVID condition in patients with inflammatory rheumatic diseases (The Lancet)
• Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition (The Lancet)
• Metformin reduces SARS-CoV-2 in a Phase 3 placebo controlled clinical trial (MedRxiv)
• Persistent serum protein define an inflammatory subcategory of long COVID (Nature)
• Relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome (JTM)
• Contribute to our FIMRC fundraiser at PWB
• Letters read on TWiV 1016
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv