This Week in Virology

Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Dan Wilson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Joe Rogan's worst misinformation yet, with RFK Jr. (YouTube) Every first vaccine has been tested in placebo-controlled trials before going to market. Polio Measles HPV COVID-19 HepB Haemophilus influenzae B Pertussis Diphtheria Tetanus Pneumococcal Mumps Meningococcal Chickenpox HepA KiGGS Study results on atopic diseases after vaccination (Vaccine) Vaccine history by year (CHOP) Financing vaccines in the 21st Century (Nat Acad Press) DALY rates from non-communicable diseases (Our World in Data) Science loses one to creationism (WaPo) Children's Health Defense (Wikipedia) COVID-19 vaccines saved 3 million US lives (CIDRAP) Beyond the Noise with Paul Offit (YouTube) Letters read on TWiV 1026 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz G.O.A.T.S – Louis Armstrong, Duke Ellington, Ella Fitzgerald Brianne – Defining the Anthropocene? Kathy – How to use your thermostat on A/C Rich – Star Trek: Strange New Worlds Vincent – Step Aside, Joe Biden Listener Picks Kim – Virus found in a boreal lake links ssDNA and dsDNA viruses and Structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection, COVID-19 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with Nirmatrelvir plus Ritonavir versus untreated controls, exaggerated blood pressure elevation in response to orthostatic challenge a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization, long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism, and risk of cardiovascular disease after COVID‐19 diagnosis among adults with and without diabetes. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New risk assessment for H5N1 avian flu viruses (CDC) Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure (Virology) Repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection (eClinicalMedicine) COVID-19 Rebound Study (CID) Exaggerated blood pressure elevation in response to orthostatic challenge (AN) Long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism (TR) Risk of Cardiovascular disease after COVID‐19 diagnosis among adults with and without Diabetes (JAHA) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1025 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test for measuring production consistency of oral poliovirus vaccine. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mikhail Chumakov (Wikipedia) MAPREC (WHO pdf) Kostya Chumakov Symposium (YouTube) Maprec and monkey neurovirulence of OPV (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and how the COVID-19 pandemic has impacted her craft. Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Katherine Wu Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server All Katherine's articles at The Atlantic Vaccines still blocking severe disease (The Atlantic) Calling Omicron mild is wishful thinking (The Atlantic) Tattoos do odd things to the immune system (The Atlantic) The Story Collider Timestamps by Jolene. Thanks! Weekly Picks Brianne- Maropeng caves and Finding Homo naledi Kathy – Being Mary Tyler Moore Vincent – Google Isn't Grad School Listener Picks John – A new study found people are terrible at sitting alone with their thoughts. Alan – What if all viruses vanished? Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 Infection, effectiveness of the COVID-19 bivalent vaccine, oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults ages 18-50 years, genome-wide association study of long COVID, vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections, and high incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Autochthonous leprosy in the United States (NEJM) Systematic review to identify novel clinical characteristics of Monkeypox (Archives of Virology) Two-year duration of immunity of inactivated poliovirus vaccine (JID) Evaluation of novel oral polio vaccine type 2 SIA impact in a outbreak of vaccine-derived poliovirus in Nigeria (IDSA) Performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 (AIM) Effectiveness of the COVID-19 bivalent vaccine (OFID) Oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults (CID) Genome-wide association study of long COVID (medRxiv) Vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections (JID) High incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID (AJM) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1022 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evolution of SARS-CoV-2 from January 2020 through Omicron. Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Trevor Bedford Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Nextstrain Household influenza testing (Influenza Other Resp Viruses) SARS-CoV-2 outbreak Washington (Sci Transl Med) SARS-CoV-2 surveillance, Washington (Emerg Inf Dis) S1 changes drive SARS-CoV-2 clade success (Cell Host Micro) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong, safety, immunogenicity and protection of heterologous boost with an aerosolized Ad5-nCoV after two-dose inactivated COVID-19 vaccines in adults, awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure, melatonin effects on sleep quality of COVID-19 patients, female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders, and incident autoimmune diseases in association with SARS-CoV-2 infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidance on measles during the summer travel season (CDC) Infectious Diseases Society of America guidelines on the diagnosis of COVID-19 (CID) SARS-CoV-2 variants and infection rates among household and nonhousehold contacts (CDC) Effect of COVID-19 vaccination on household transmission of SARS-CoV-2 in the Omicron era (IJID) Incidence of myopericarditis after mRNA COVID-19 vaccination (Science Direct) Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant (JID) Safety, immunogenicity and protection of heterologous boost with Ad5-nCoV after two-dose inactivated COVID-19 vaccines (The Lancet) Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure (BMC) Melatonin effects on sleep quality of COVID-19 patients (BMJ) Female reproductive health impacts of Long COVID and associated illnesses (FRS) Incident autoimmune diseases in association with SARS-CoV-2 infection (CR) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1020 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere. Host: Vincent Racaniello Guest: Eddie Holmes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Market early COVID-19 epicenter (Science) SARSr-CoV-2 in Malayan Pangolins (PLoS Path) Zoonotic risk of farmed animals (Cell) Virusea at bat-tick interface (Microb Genom) Influenza H3N8 virus in southern China (J Virol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the CDC vaccine advisory group recommending the newly approved RSV vaccines, association of culturable-virus detection and household transmission of SARS-CoV-2, prevention of COVID-19 following a single intramuscular administration of Adintrevimab, real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19, and COVID-19 convalescent plasma outpatient therapy to prevent outpatient hospitalization. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CDC vaccine advisory group recommends RSV vaccines Association of culturable-virus detection and household transmission of SARS-CoV-2 (JID) Prevention of COVID-19 following intramuscular administration of Adintrevimab (OFID) Real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19 (CID) COVID-19 convalescent plasma outpatient therapy to prevent hospitalization (CID) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1018 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, and public and political perception of scientific risk. Host: Vincent Racaniello Guests: Susan Weiss, Rick Bushman, Gigi Gronvall, and David Joanson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Market early COVID-19 epicenter (Science) Spillover market with Michael Worobey (TWiV 876) Unclassified intelligence on SARS-CoV-2 origins (IC) Conspiracy theories about COVID-19 (Foreign Policy) COVID-19 not from lab leak (Globe and Mail) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv