This Week in Virology

Hosts: Vincent Racaniello, Amit Kapoor, Lan Quan, and Ian Lipkin Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents. Links for this episode: Canine hepacivirus (TWiV 137) Rodent homologs of hepaciviruses and pegiviruses (mBio) Bats are a reservoir of hepaciviruses and pegiviruses (PNAS) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus. Links for this episode: Francois Jacob dies (The Loom) WHO updates on H7N9 H7N9 is unusually dangerous (ScienceInsider) H7N9 case imported into Taiwan No H7N9 in poultry farms (Xinhua) Supreme Court considers gene patents (TheScientist, Nature) Patent my jeans, not my genes (Michael Wosnick) Receptor binding by ferret transmissible H5 virus (Nature) Microscale thermophoresis and bio-layer interferometry (Wikipedia) Letters read on TWiV 230 Weekly Science Picks Alan - World Science FestivalRich - 3 years of the sun in 3 minutesVincent - The Origin of AIDS by Jacques PepinKathy - Wringing out a wet washcloth in space (YouTube) Listener Pick of the Week Mark - Will it blend? (iPhone app)Marianne - Enjoy your Cells Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus. Links for this episode: Hilary Koprowski, 96 (NY Times) Koprowski, Kessin, Racaniello photo Listen to the Music by Roger Vaughan Influenza ocular infections (one, two) H7N9 global concerns (NEJM) Human infection with H7N9 (NEJM) WHO Global Alert and Response, H7N9 Avian influenza A(H7N9) virus (WHO) Novel H7N9 reassortant, implications for Europe (Eurosurveill) Genetic analysis of H7N9 (Eurosurveill) H7N9 compared with H7N7 outbreaks (Eurosurveill) Image credit: Eurosurveillance Letters read on TWiV 229 Weekly Science Picks Alan - Nature PastCastRich - How dengue does itVincent - Squeaky Squeegee Art by Deb SklutDickson - Agritecture Listener Pick of the Week Mike - Chemistry in its element: Elements and Compounds Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Britt Glausinger, and Eva Harris Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus. Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay. Links for this episode: RNA element in IL-6 confers SOX resistance (J Virol) Dual uORFs regulate herpesviral translation (PLoS Path) Common viral strategy for RNA degradation (J Virol) KSHV SOX and Xrn1 together degrade host mRNAs (PLoS Path) Dengue treatment with Fc null antibodies (PLoS Path) Early clinical features of dengue in Nicaraguan children (PLoS Negl Trop Dis) Intrahuman dengue virus diversity (J Virol) Dynamics of dengue disease severity (Sci Transl Med) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus. Links for this episode: Containment plan for poliovirus (pdf, WHO) Post-eradication of polio Ocular tropism of respiratory viruses (MMBR) Rally for medical research HeLa genome sequence withdrawn (ScienceInsider) Immortal life sequel (Rebecca Skloot) HeLa genome sequence published, withdrawn (virology blog) Vial of Guanarito virus missing (ABC news) Human H7N9 infections (ProMedMail) WHO H7N9 updates China escalates H7N9 response (NY Times) Brian Kimble on H7N9 Compatibility of H9N2 and H1N1 genes (PNAS) Letters read on TWiV 227 Weekly Science Picks Kathy - NIAID YouTube videosAlan - Lego insectsRich - How to see the world in a grain of sandVincent - Vaccines, viruses, and the anti-vax movementDickson - Edinburgh Science Festival Listener Pick of the Week Stephen - Nature iOS appMehul - Voices for vaccines Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, and Terry Dermody Vincent and Dickson speak with Terry Dermody about his career in medicine and virology. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more. Links for this episode: Plant viruses alter insect behavior (Sci Rep) Circovirus in Shanghai Letters read on TWiV 225 Weekly Science Picks Kathy - Case stories about CoV-EMC (one, two)Rich - The Self-Illusion by Bruce HoodVincent - Moving Targets Listener Pick of the Week Liam - eLIFE and RubriqSteve - Plant virus ecology (mp3)Neil - World Immunization Week Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract. Links for this episode: Dipeptidyl peptidase 4 is CoV-EMC receptor (Nature) Receptor for new coronavirus (Nature) Broad reception for coronavirus (Nature) SARS 10th anniversary (Science) Interferon-epsilon protects female reproductive tract (Science) Families fighting flu (YouTube) Monitoring infections with online data (TWiM 41) Natalie Portman was a scientist (NY Times) Letters read on TWiV 223 Weekly Science Picks Kathy - 2013 Intel Science Talent Search awardsAlan - Krebs Cycle Rap (CDC)Vincent - Jetpens (favorite one and two)D ickson - Rabies death in organ recipients (CDC) Listener Pick of the Week Justin - The DNA StoreJim - Massive Open Online ClassroomsChris - Feedly Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells. Links for this episode: International Women's Day 2013 Condit Dam, 6 weeks later (Vimeo) Influenza HA assay Covalent influenza NA inhibitors (ScienceExpress) Defective influenza HA mutants (Virology) New flu drug (BBC, e! Science) EEEV antibody, RNA in snakes (Am J Trop Med Hyg) EEEV (CDC) Zoonotic potential of CoV-EMC (mBio) CoV-EMC update (ProMedMail, CDC) CoV-EMC travel update (CDC) Letters read on TWiV 223 Weekly Science Picks Kathy - Finkbeiner test and Women in ScienceAlan - New flu vaccine efficacy study (CDC)Vincent - Threading the NEIDL video Listener Pick of the Week Steve - Prof. Joan Steitz on viral RNAEd - Archiving history of molecular biology: Press release, video, CSHL archives and videos Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor. Links for this episode: Zhijian J. Chen (Wikipedia) Sensing the dark side of DNA (Science) cGAMP is an endogenous second messenger (Science) cGAMP synthase is a DNA sensor (Science) Pore-forming toxin (Wikipedia) Letters read on TWiV 222 Weekly Science Picks Kathy - Graphene batteriesAlan - How do we get cures? (YouTube)Rich - Explosive breach of Condit Dam (Vimeo)Vincent - 10 things you can do to support open access (Tree of Life) Listener Pick of the Week Mark - The real story of StuxnetJohn - D-connector virus Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv