This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV. Links for this episode: Human transmission of SFTSV (JID) SFTSV serosurvey (EID) SFTSV on TWiV 147 SFTSV in Japan (ProMedMail) SFTSV mouse model (PNAS) SBV infectious DNA and mouse model (PLoS Path) SBV in Sweden (ProMedMail) Letters read on TWiV 221 Weekly Science Picks Kathy - Winners, 2012 Science & Engineering Visualization ChallengeVincent - The Operator and Dr. Oz's Problem Listener Pick of the Week Shane - OpenPCRJohn - Python Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk. Links for this episode: Influenza splicing regulates infection (Cell Reports) Reporting on flu splicing from NPR, BBC, NBC Splicing of influenza RNA 8 (jpg) Bacteriophage T7 remodeling during infection (Science) Cryo-ET of intact cells (Trends Cell Biol) T7: The Movie (YouTube) Cry0-EM vs Cryo-ET (Wikipedia) Virus caught in the act (e! Science News) Letters read on TWiV 220 Weekly Science Picks Kathy - Journal of Virology Image GalleryRich - Phage T7 Genetics and Physiology and slab gelsAlan - PeerJ (press release)Vincent - Virologia en Español Listener Pick of the Week Dave - Thingiverse pathogens and proteins Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, and Anthony S. Fauci Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases. Links for this episode: Fauci history (J Clin Inves) Fauci Pharmacy Anthony Fauci (Wikipedia) Anthony Fauci: Unfinished business (Lens) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Welkin Johnson Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response. Links for this episode: Kuan-Teh Jeang, 54 Resurrection of ERVs (Nature) Toll-like receptors control ERVs (Immunity) Retroviral danger from within (Immunity) Ancient viruses wreak havoc (The Scientist) Letters read on TWiV 218 Weekly Science Picks Welkin - Viruses: Essential Agents of Life (review at STC)Alan - Infinity ImaginedVincent - Spaceship built for son Listener Pick of the Week Amanda - Written? Kitten!Kevin - Protein synthesis: An epic (YouTube)Daria - The Baltimore Scheme Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Dickson Despommier Vincent, Alan, Rich, and Dickson review influenza vaccines. Links for this episode: FDA licensed flu vaccines Seasonal influenza vaccine distributed How flu vaccine strains are selected (one, two) WHO report on flu vaccine strain selection (pdf) Derek Smith on antigenic mapping Salk's 1945 influenza vaccine TIV preparation: Fluzone, Agriflu, Fluvirin, Fluarix, Flulaval, Afluria (pdfs) LAIV preparation (pdf) Efficacy of flu vaccine 2012-13 (MMWR, virology blog) Meta-analysis of flu vaccine efficacy (Lancet) Two new flu vaccines FDA approved Flublok Flublok clinical trial Pandemrix and narcolepsy (Yahoo, PLoS One, PLoS One) CIDRAP analysis of flu vaccines Letters read on TWiV 217 Weekly Science Picks Rich - Repoopulate (original article), Robogut (new clinical trial)Alan - WTF, Evolution?Dickson - The Beauty and Benefits of ScienceVincent - Supercomputing modeling of poliovirus Listener Pick of the Week Bjorn, Marshall, Meaghan - Glass sculptures of Luke Jerram Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export. Links for this episode: Slides for this episode (pdf) Spliced Ad 2 late mRNAs (Cell) An amazing sequence arrangement (Cell) Adenovirus late mRNA undecanucleotide (Cell) Aaron Shatkin, 72 (virology blog) Schrödinger's cat (Wikipedia) Letters read on TWiV 216 Weekly Science Picks Rich - Linus Pauling's explanation of science (YouTube)Alan - Underwater experimentsKathy - I'm a virus (YouTube)Vincent - Stem cells (Bizarro Comics) Listener Pick of the Week Tom - The President's AnalystDanielle - Overly honest methods (HuffPost and ASBMB Today) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East. Links for this episode: Neuronal survival after rabies virus infection (PLoS Path) Clusters of coronavirus cases (Nature) ProMedMail on novel coronavirus Novel coronavirus outbreak news (Int J Inf Dis) Genomic characterization of novel coronavirus (mBio) Broad cell tropism of novel coronavirus (mBio) Are viruses alive? (poll at virology blog) Antibodies taken up by endocytosis (PNAS) Antibody eliminates alphaviruses from neurons (Science) Image: Virus in the garden by Helen Hache Letters read on TWiV 215 Weekly Science Picks Alan - I'm a Scientist - The FilmKathy - Humorous units of measurement (Wikipedia)Vincent - Open access must enable open use (Nature) Listener Pick of the Week Tarwin - Plague Inc. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons. Links for this episode: Coagulation factor X activates innate immunity to adenovirus (Science) A decorated virus cannot hide (Science) Reflecting on goals for Science Polyomavirus associated with raccoon brain tumors (EID) MPNST Moore tumor viruses - TWiV 160 Treating CLL with lentivirus vectors (NEJM) Letters read on TWiV 214 Weekly Science Picks Alan - Parasite of the DayKathy - Tour of International Space StationVincent - Earth as Art Listener Pick of the Week Robin - Angell on Big PharmaMichael - Flu jokesJim - Database of Ted talks; Downloadable Ted Talks Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012. Twelve virology stories from 2012: H5N1 (TWiV 190, 182, 177, 173, 168) Polymorphisms that control susceptibility (TWiV 175, 180) New virus receptors (TWiV 166, 210) XMRV: Last nail in the coffin (TWiV special) Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog) Biomedical research crisis (TWiV 208, 184, 189, 194) Polydnaviruses in parasitoid wasps (TWiV 179) Carolyn Coyne’s placental barrier story (TWiV 193) Touring NEIDL (TWiV 200) Epidemiology (TWiV 169, 178) A good year for virus hunting (173, 183, 195, 196, 198, 199, 204) Pox accordion (TWiV 198) Links for this episode: US plans for H5N1 research (ScienceInsider) FDA recommends against Ampligen Rituximab and CFS (PLoS One) No evidence for XMRV in prostate cancer (PLoS One) Retraction of XMRV prostate cancer paper (Retraction Watch) Gender bias among science faculty (PNAS) NEIDL risk assessment Virology 101 at TWiV Letters read on TWiV 213 Weekly Science Picks Rich - Our Mr. Sun (IMDB entry) (wiki)Alan - PubReader from NCBI announcement and instructionsKathy - Popular Mechanics 110 picks for the next 110 yearsVincent - 366 days: Nature's 10 Listener Pick of the Week Matt - The flu vaccine controversy Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Stuart Firestein Vincent and Stuart discuss why ignorance - all of what we don't know, and even what we don't know we don't know - is the driving force of science. Links for this episode: Ignorance: How it drives Science by Stuart Firestein Ignorance website Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv