This Week in Virology

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933. Links for this episode: Human placental trophoblasts confer viral resistance (PNAS) Placental circulation (Wikipedia) Ovum in uterine decidua (Wikipedia) A virus obtained from influenza patients (Lancet) 80 years ago today (the guardian) Influenza: Exposing the true killer (J Exp Med) Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories) Listener Pick of the Week Joe - Grand challenges in science education (Science)Mark - Weather Underground Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Markus Thali and Jason Botten Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus. Links for this episode: MERS-CoV update (WHO) MERS-CoV evolution (epidemic) Sick camel linked to MERS-CoV death (7Days) MERS-CoV hospital outbreak (NEJM) MERS-CoV French hospital cluster (Lancet) MERS-CoV family cluster (NEJM) Matt on MERS-CoV on the Voice of Russia Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories) Listener Pick of the Week Ebrahim - Virus Hunter by CJ Peters and Mark Olshaker Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells. Links for this episode: Slides for this episode (pdf) T7 ribosomal binding sites (CSH Symp Quant Biol) Tinkering with translation (CSH Persp) Translation at nexus of infection and immunity (Cell Host Microbe) Viral subversion of protein synthesis machinery (Nat Rev Micr) Weekly Science Picks Kathy - Vaccine-preventable outbreaksRich - To Catch a Virus by John Booss and Marilyn J. AugustVincent - This is Water by David Foster Wallace Listener Pick of the Week Jon - Confessions of a converted lecturer by Eric MazurPeter - FameLab Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guest: Michael Emerman Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis. Links for this episode: Ancient origins of SIV (PLoS Path) Paleovirology (PLoS Biology) Harmit Malik on TWiV 205 Sara Sawyer on TWiV 193 Listener Pick of the Week Molly - Facts in the case of Dr. Andrew Wakefield Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection. Links for this episode: Ultraprotective influenza vaccine in mice (PNAS) Vectored immunoprophylaxis of influenza in mice (Nat Biotech) Intranasal antibody gene transfer protects agains influenza (Sci Transl Med) Estimating influenza associated deaths (CDC) Multistate HAV outbreak (CDC) Subscribe to Microbeworld video (YouTube) Save podcasting (EFF) Letters read on TWiV 236 Weekly Science Picks Alan - Psychology of antivaccinationistsVincent - Virology on CourseraKathy - Meteorites through the ages Listener Pick of the Week Basel - Self-medication in animalsSheryl - Noadi's artFelicity - Survival of the Sickest by Sharon Moalem Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guests: Dave Evans, Stan Lemon, and Lorne Tyrrell Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta. Links for this episode: Li Ka Shing Institute of Virology Alberta Heritage Foundation for Medical Research Raised on a farm (YouTube) Vaccinia virus strains in Dryvax vaccine (J Virol) Vaccinia DNA polymerase and recombination (J Virol) Picornavirus hijacks cell membrane (Nature) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Kathy Spindler Guests: Nels Elde and Tom Shenk Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome. Links for this episode: A cross-species view on viruses (Curr Op Virol) Pox has got a squeeze box (TWiV 198) Saturated fatty acids needed for CMV (PLoS Path) CMV and HSV metabolomes differ (PLoS Path) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus. Links for this episode: Aerosol transmission of H1N1 x H5N1 reassortants (Science) It's good science (virology blog) Viral engineering dangers (Nature) Colorblind web page filter Influenza H7N9 update (ProMedMail) Influenza H7N9 risk assessment (WHO, pdf) Influenza H7N9 confirmed cases (WHO) New coronavirus gets a new name (ScienceInsider) Novel coronavirus infection update (WHO) Coronavirus infections (WHO) Letters read on TWiV 233 Weekly Science Picks Alan - Space Oddity (YouTube)Rich - Walk through giant colonVincent - Transport proteinsKathy - Vomiting Larry (YouTube) Listener Pick of the Week Tom - US patent system is broken (DailyTech) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Roberto Cattaneo, Reuben Harris, Lou Mansky, and Leslie Schiff Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates. Links for this episode: University of Minnesota virology timeline Revisiting HIV-1 lethal mutagenesis (Trends Micro) Exploiting HIV-1 drug repositioning (J Virol) 5-azaC induces HIV-1 lethal mutagenesis (J Virol) HIV-1 fitness and mutation rate (J Mol Biol) APOBEC3 mutagenesis in breast cancer (Nature) Restriction factors of HIV (J Biol Chem) Nectin-4 is epithelial measles receptor (Nature) Photographs of this episode: Click here Video of this episode - YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv