This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The complete TWiV crew reviews work on MERS-coronavirus, including serological studies in camels, production of an infectious DNA clone, and identification of an interferon antagonist. Links for this episode: Stephan Chron dies (NY Times) Philip Marcus dies (NY Times) Philip Marcus on TWiV #197 Ellen Fanning dies (news@Vanderbilt) Donald Low dies (CBC News) MERS timeline MERS-CoV seroepidemiology (Eurosurveillance) MERS-CoV neutralizing antibodies in camels (Lancet Inf Dis) MERS-CoV vaccine candidate (mBio) MERS-CoV infectious DNA (PNAS) MERS-CoV protein 4a is IFN antagonist (J Virol) Letters read on TWiV 251 Weekly Science Picks Dickson - Scharf PhotoKathy - Blaschka glass models (NY Times, Cornell)Alan - Digital Public Library of AmericaRich - Dengue virus life cycle animationVincent - Creative Live Listener Pick of the Week John - Last person to get smallpox (NPR)Peter - SARS documentary (BBC) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Robert Garcea Vincent and Robert recorded this episode at the 53rd ICAAC in Denver, where they talked about polyomaviruses. Links for this episode: A cornucopia of human polyomaviruses (Nat Rev Micro) Polyoma assembly factories in nucleus (PLoS Path) Overprinting gene in Merkel cell polyomavirus (PNAS) Human JCV as population marker (PLoS One) Letters read on TWiV 250 Video of this episode (YouTube) Weekly Science Picks Robert - The Panic Virus by Seth MnookinVincent - Aliens chestburster behind the scenes Listener Pick of the Week Adam - Virology Fact of the DayChristophe - dr Karl Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Vincent, Dickson, Alan and Rich discuss an estimate of the number of different mammalian viruses on Earth. Links for this episode: Estimate of unknown viral diversity in mammals (mBio) How many viruses on Earth? (virology blog) Letters read on TWiV 249 Weekly Science Picks Alan - Extreme macrophotographyDickson - Baloney detection kitRich - Mutant silkworms spin colored silk (original article)Vincent - FlightRadar24 Listener Pick of the Week Jenn - Ebola by William CloseJenn - Eleven Blue Men by Berton RouecheNissin -Profiles in Science Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Vincent, Dickson, and Rich reveal how experiments with a malaria parasite lead to the introduction of a mammalian retrovirus into birds. Links for this episode: Scientists cast doubt on MERS origin (NY Times) Animal reservoirs of SARS coronavirus (Virus Res) Jo Handelsman in the White House Origins of REV (PLoS Biology) Inadvertent transfer (virology blog) Mongoose, pheasant, pox, retrovirus (PLoS Biol) Evolutionary history of REVs Amazing story (Ed Yong) My wife's P. lophurae paper (Mol Bio Parasitol) William Trager's SNV paper (Exp Biol Med) EBV detection tests (Clin Diag Lab Immunol) Letters read on TWiV 248 Weekly Science Picks Dickson - Google SkyRich - Vanishing of the Bees (see also Bee Apocalypse Now)Vincent - Not Exactly Rocket Science Listener Pick of the Week Saira - Reproducibility Initiative Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Special guest: Ian Lipkin Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus. Links for this episode: MERS-CoV in bats (EID) Mystery virus (NY Times) Part of MERS-CoV found in bat (virology blog() T. perforatus Frag virus (Virol J) Even Nature got it wrong! (Nature) Bats: Important reservoirs of emerging viruses (Clin Micro Rev) Letters read on TWiV 247 Weekly Science Picks Kathy - Rainbows explained (Frazz)Alan - Challenge.govVincent - 23andmeRich - Spot the station Listener Pick of the Week Frank - Pacifier cleaning practices and risk of allergy development (Pediatrics) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence. Links for this episode: Pandoraviruses (Science) Unlike anything seen before (virology blog) H7N9 gain of function experiments planned (Nature, Science) Virologists plan H7N9 gain of function experiments (virology blog) Creating a deadly virus? Not!! (USA Today) HeLa cell genome sequence (Nature) NIH Director explains HeLa agreement (Nature) HeLa deal (Nature) Biospecimen policy (Nature) Sequencing HeLa the right way (turbidplaque) Skloot on HeLa deal (The Scientist) HeLa deal (NY Times, USA Today) Picture on Condit's wall (EID) Letters read on TWiV 246 Video of this episode - view below or at YouTube Weekly Science Picks Kathy - GeoGuesserAlan - From one, many (YouTube)Vincent - Dave Bhella: The Wildy Award Talk (Microbeworld video)Rich - 1981 primitive internet report (YouTube) Listener Pick of the Week CN - How the Mind Works by Steven Pinker Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: S. Jane Flint, Lynn Enquist, Glenn Rall, and Ann Skalka The authors of the popular textbook Principles of Virology discuss how the book was conceived and written. Links for this episode: Principles of Virology Lahiere's General Virology by SE Luria Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Alan Dove Guests: Dan Barouch and Jeff Teigler This episode of TWiV was recorded before an audience at the Beth Israel Deaconess Medical Center, where Vincent and Alan spoke with Dan and Jeff about AIDS vaccines. Links for this episode: Human study of adenovirus 26 HIV-1 envelope vaccine (J Inf Dis) Seroepidemiology of adenovirus serotypes (Vaccine) SIV infection associated with expansion of gut virome (Cell, TWiV #204) Global approach to HIV-1 vaccine development (Immunol Rev) Innate cytokine responses to adenoviruses (J Virol) microRNAs as mediators of viral evasion (Nat Immunol) Letters read on TWiV 244 Weekly Science Picks Jeff - Science in the News; How to succeed in science (part one and part two)Alan - Nanostructure flowersVincent - Scientific culture Listener Pick of the Week Basel - The sequester blues Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Rebecca Dutch and Christiane Wobus On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses. Links for this episode: TWiV 143 with Stephanie Karst American Society for Virology Mouse model for human norovirus (mBio) Paramyxovirus fusion (Viruses) Photo credit: Matt Evans Weekly Science Picks Kathy - Shuffling cardsVincent - Dave Bhella - Electron cryomicroscopyRich - Seven-year postdoc Listener Pick of the Week Judi - Reading for science literacy Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein. Links for this episode: Dual virus-host arms race (PLoS Biology) Dual virus-receptor duel (see comments - virology blog) Ferritin and transferrin (Protein Data Bank) Money for nothing (YouTube) Letters read on TWiV 242 Weekly Science Picks Dickson - Mantid imagesKathy - No email? (phd comics)Alan - The turbid plaqueVincent - AAM Faq: West Nile VirusRich - Science is awesome Listener Pick of the Week Luis - Public Health Image LibraryStephen - Hopkins closes graduate science-writing program Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv