This Week in Virology

Hosts: Vincent Racaniello and James Van Etten Guests: Chantal Abergel and Jean-Michel Claverie Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus. Links for this episode Unanswered giant virus questions (Adv Virus Res) Fourth domain of life (Commun Integr Biol) Pandoraviruses (Science) Phaeocystis globosa virus (PNAS) Cafeteria roenbergensis virus (PNAS) Symposium group photo (jpg) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Tom Friedrich, Tony Goldberg, and David O'Connor Vincent visits the University of Wisconsin, Madison and speaks with Tom, Tony, and David about their work on virus discovery at the AIDS Vaccine Research Laboratory. Links for this episode A tick in Tony's nose (Am J Trop Med Hyg) Two new SIV from colobus monkeys in Uganda (Biomed Cent) Pegivirus diversity in Uganda (J Gen Virol) Simian hemorrhagic fever virus diversity in African primates (J Virol) Video of this episode - coming soon Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guest: Jaquelin Dudley Vincent and Rich join Jackie at the University of Texas, Austin to talk about her work on mouse mammary tumor virus. Links for this episode Rem signal peptide processing and function (J Virol) MMTV null mice and tumorigenesis (J Virol) Jackie's publications (PubMed) I want my MMTV (TWiV 242) Live at ASV in Madison (TWiV 193) Symbiotic safecrackers (TWiV 154) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Matt Frieman Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus. Links for this episode SARS-like virus in bats binds ACE2 (Nature) Bat SARS-like virus that infects human cells (virology blog) Coronavirus infections update (WHO) Lack of MERS coronavirus antibodies in humans (EID) Mice not susceptible to MERS-CoV (J Gen Virol) MERS-CoV case imported into Spain MERS-CoV like virus in European hedgehogs (J Virol) DPP4 amino acids positively selected in bats (Virol J) Image credit: Richie Frieman Letters read on TWiV 258 Weekly Science Picks Kathy - Optical illusion (YouTube)Alan - AmboceptorMatt - Reply all by Richie Frieman (audio sample)Vincent - The microbiology of beer Listener Pick of the Week Cassie - NeatoShopPeter - Synapse evolution with Seth Grant (BSP 101) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team consider how the kinase mTOR modulates the antibody response to provide broad protection against influenza virus, and explore the problems with scientific research. Links for this episode Two lives intertwined (Ann Rev Imm) John Holland, 83 Kinase mTOR modulates antibody response (Nat Imm) Drug widens immunity to flu (TheScientist) Concerto in B (TWiV 161) How science goes wrong (Economist) Trouble at the lab (Economist) Reforming science (TWiV 184) Letters read on TWiV 257 Weekly Science Picks Dickson - Tesla Motors superchargerKathy - FASEB contest: Stand out for scienceAlan - Natural History Museum virtual tourRich - Mauna Kea heavensVincent - FAA expands use of electronics on planes Listener Pick of the Week Peter - Score and ignore (pdf) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Dickson, Alan, Rich, and Kathy review two papers that present evidence for RNA interference as an antiviral immunity mechanism in mammals. Links for this episode: World Polio Day Mole Day John Holland's publications RNAi is antiviral in mammals (Science) Antiviral RNA interference in mammals (Science) RNAi, antiviral after all (Science) Is RNA interference antiviral in mammals? (Cell Host Microbe) Nodamura virus (Nature) Ebolavirus proteins suppress RNAi (J Virol) Illustrated is an siRNA (orange), dicer (top right), and argonaute (bottom) Letters read on TWiV 256 Weekly Science Picks Dickson - Wildlife Photographers of the Year 2013Kathy - John Holland's Emerging Infectious Disease lecture (YouTube)Alan - The worst part is notRich - The Universe in a Single Atom by Dalai Lama (Mind and Life Institute)Vincent - The Truth about T. Rex by Brian Switek Listener Pick of the Week Stephen - International Institute for Species Exploration (Top 10 species choice) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guests: Robert Krug and Christopher Sullivan Vincent and Rich visit the University of Texas at Austin and meet up with Bob and Chris to talk about their work on influenza virus and microRNAs. Links for this episode: Virus-encoded microRNAs (PLoS Path) microRNA targetomes of polyomavirus (J Virol) Innate and RNAi reciprocal inhibition (Cell) ISG15 pathway (Trends Micro) Role of viral NS1 protein (Virology) Cap-snatching (Cell) Weekly Science Picks Rich - Unraveling BoleroVincent - New botulinum toxin, DURC implications, and inconvenient truths Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Vincent, Dickson, Alan, and Kathy review clearance of simian immunodeficiency virus infection from macaques by immunization with SIV proteins encoded in a rhesus cytomegalovirus vector. Links for this episode: Immune clearance of SIV infection (Nature) Rhesus CMV vectors (Nature Medicine) Types of memory T cells (WikiPedia) Goldilocks approach to vaccines (Scilogs) Chimeric HA influenza vaccine (J Virol) Influenza vaccine matched vs mismatched (BMC Medicine) Letters read on TWiV 254 Weekly Science Picks Dickson - The Man Who Planted Trees by Jean GionoKathy - A boy and his atom and Moving Atoms (YouTube)Alan - It is pitch dark and Get Lamp (YouTube)Vincent - Who's afraid of peer review? (Science) Listener Pick of the Week Maren - Hello Maestro (episodes on YouTube)Ayesha - Why you don't f****** love scienceJon - A Capella Science (YouTube) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler In this second consecutive all-email episode, the complete TWiV team reads questions and comments from listeners about systemic antiviral responses, wild type poliovirus in Israel, Turkish scientists, viral symbiotes, and much more. Links for this episode: One Nation in support of biomedical research? Bilim Kazani (The Cauldron of Science) Science for Gezi State of Turkish Science Pathogenesis of feline coronavirus (EID) Dinosaurs plagued by infection (PLoS One) Dinosaur renaissance (WikiPedia) Birds are dinosaurs (AMNH) Influenza vaccine enhances disease in pigs (Sci Transl Med) Gut microbes influence B-cell development (Nature) Circovirus in dogs (EID) We the microbiologist Letters read on TWiV 251 Weekly Science Picks Dickson - HD slow motion montage (YouTube)Kathy - Damselflies and Eyewitness appAlan - Space weather forecast (YouTube)Rich - 1984 by George Orwell (Doublethink)Vincent - PopSci comments off and Why so few women in science? Listener Pick of the Week Meika - Flip action roll (YouTube)CN - Blink: The Power of Thinking without Thinking by Malcolm GladwellBernadeta - Higgs Boson wins Nobel Prize Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The complete TWiV team reads email from listeners about anti-vaccine activists, a career in microbiology, placentas, a virology textbook, the HeLa cell genome, norovirus, and much more. Links for this episode: Anthropic principle 1999 vaccine article by Alan Dove (Nature) Image credit: Jason Roberts Letters read on TWiV 251 Weekly Science Picks Dickson - A Sand County Almanac by Aldo LeopoldKathy - Noctilucent clouds and aurora over ScotlandAlan - Flu vaccination mapRich - There's a fly in my urinalVincent - Picornaviridae.com Listener Pick of the Week Peter - PDB-101Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv