Artificial Intelligence was once the realm of science fiction. But over the last several years, advances in machine learning and deep neural networks have moved us closer to a reality where computers can learn and solve problems independently, the way a human does. From art and music to medicine and politics, the potential applications of AI are nearly endless, and the technology just keeps getting better.This week on How I Built This Lab, Guy talks with one of the leaders in the field of AI development, Sam Altman. Sam talks about his journey from Stanford dropout and teenage entrepreneur to president of the legendary startup incubator Y Combinator and co-founder of the nonprofit OpenAI. Plus, Sam shares his hopes and fears for the future of AI and how his company is working to ensure it ultimately benefits all of humanity. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Wherever Bill Simmons is, he’s obsessed with helping his team win. During 14 tumultuous years as a creative force at ESPN, that meant launching a slew of influential projects that blended sports and pop culture—including the documentary series 30 for 30, the podcast The B.S. Report, and the multimedia blog Grantland. Today, it means growing his own company, The Ringer, into a major player in the media landscape, with over 50 sports and pop culture podcasts. From his earliest days as one of the most popular sports writers in America, Bill’s journey has had all the drama and conflict of a memorable game, with plenty of good and bad behaviors to learn from...including his own.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Biobot Analytics founders Mariana Matus and Newsha Ghaeli first met in a poop lab. Yep, you read that correctly...Their company has been working with government and corporate clients since 2017 to analyze disease levels and other biomarkers in our wastewater. Their insights have been used to predict spikes in Covid and other infections, help local officials address drug use in their communities, and much more. This week on How I Built This Lab, Mariana and Newsha talk with Guy about the innovation that can happen at the intersection of disciplines — Mariana is a scientist from Mexico, Newsha an architect from Canada. The women also share their vision for a future where cities better leverage the ‘data centers’ of our sewers to address chronic health issues and prepare for future pandemics. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Working as a manager for nine years at JCPenney, Tom Campion learned a critical lesson about how to succeed in retail: you have to keep close track of inventory. Tom’s experience navigating the ebb and flow of style, color, and size—all without the benefit of computers—gave him the confidence to launch his own retail business, aimed at teenagers. In 1978, he and his partner Gary Haakenson opened their first store, Above the Belt, in Seattle, and soon tapped into the hot new “action sports” category and the growing popularity of surf, skateboard, and snowboard culture. Tom placed his stores in shopping malls, and created spaces where teenagers would want to hang out, by leaning into “organized chaos” as a design principle. Today, with roughly 750 stores, Zumiez is the largest action sports retailer in the world.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Chef Sean Sherman is on a mission to revitalize and reimagine Native American cuisine. Growing up on a reservation in South Dakota, Sean ate a lot of highly processed foods provided by the U.S. government. It wasn’t until he started working in restaurants as a teenager that he began to learn about fresh ingredients and how to prepare them. But as Sean climbed the kitchen ranks, learning the techniques and recipes of European-style fine dining, he began to wonder what happened to the culinary traditions of his Native American ancestors. This week on How I Built This Lab, Sean talks with Guy about establishing a modern North American indigenous cuisine by cutting out non-native ingredients such as pork, chicken, beef, dairy, wheat and cane sugar. Instead, he cooks with heirloom varieties of corn, wild rice, foraged plants and native animals such as bison, salmon, duck and beaver. Under The Sioux Chef brand, Sean has hosted pop-up dinners, published a cookbook, operated a food truck, and in 2021, he opened Owamni, which won the James Beard Award for Best New Restaurant.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When steaks don’t sell you shift to sticks; that’s how Chomps was born. After several failed ventures—one of which left him bankrupt—Pete Maldonado decided to take another chance on launching a business. He partnered with Rashid Ali to start a mail-order service similar to Omaha Steaks, but with grass-fed meat that was more suited to the Paleo diet. When the partners couldn’t get that off the ground, they shifted to individually-wrapped meat sticks; one of the first in a long line of ‘healthier for you’ protein snacks. For several years, each co-founder tried to manage the business as a side-hustle, but the sausage hit the fan in 2016 when a surprise order from Trader Joe’s left them scrambling to produce a million sticks. Today, Chomps is available in major chains across the country and pulls in more than $100 million a year. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Do you know who holds the record for making the world’s largest chicken nugget? How about the world’s largest sushi roll?If you know Nick DiGiovanni, then you know the answer to those questions. Each week, more than 15 million followers across YouTube and TikTok gawk and drool over Nick’s masterful and over-the-top culinary creations. Nick is at the helm of some analog business ventures too, including a DTC salt and seasoning company and his debut cookbook, Knife Drop, which publishes later this year. This week on How I Built This Lab, Nick talks with Guy about overcoming shyness to become an on-camera personality, and his recent decision to forego Harvard Business School to continue on his path as a creator. Nick also opens up about his struggles to set strong work-life boundaries and speculates about his professional future. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Let’s say you had a passion but thought of it only as a hobby; certainly never the seed of a billion-dollar company. Plus, you are studying for a career in something unrelated to business. That’s Maureen Kelly’s story, CEO of Tarte Cosmetics. She was pursuing a Ph.D. in clinical psychology and already had TWO Master’s degrees when she realized she didn't want that to be her career. What she wanted was to launch a makeup company—despite having no significant start-up money, no experience, and no connections. How she did it is a story of pure moxie. She relentlessly knocked on the doors of chemists, manufacturers, retailers, and the fashion press. She maxed out her credit cards and enlisted the help of friends and family, turning Tarte into a wildly successful brand.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When you think about self-driving cars, you might imagine relaxing in the back seat while a vehicle carries you to your destination. But according to Dave Ferguson, nearly half of all car tips that Americans take don’t actually need any passengers at all. That’s because we spend a lot of our time driving around just to pick things up, like groceries and takeout.This week on How I Built This Lab, Dave talks with Guy about his vision of a future where many of these everyday errands could be done by robots. Dave’s company, Nuro, builds autonomous vehicles that are meant to deliver goods rather than carry passengers. Already they’ve run pilot deliveries with big-name partners like Domino’s Pizza, Uber Eats, and Kroger Grocery stores, and in the next few years, they aim to expand their service to cities all across the country. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In 2007, brothers Hank and John Green lived thousands of miles apart, so they started posting video blogs to each other on a strange new platform called YouTube. People began tuning in, and the daily Vlogbrothers posts became an early viral hit. Over time, the brothers grew that single channel into a sprawling collection of businesses, including a production studio—Complexly—that makes some of the most entertaining educational content on the internet. They’re also both hugely successful authors; John’s young adult novel The Fault in Our Stars is one of the best-selling books of all time. With every success, Hank says he’s asked himself, “What’s exciting? What’s causing you the most stress? Head in that direction.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.