The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
18 snips
Dec 19, 2025 • 11min
Biohacking News Weekly Update : 1383
The FDA is considering changing supplement warning labels, which could blur the line between marketing and medical claims. A new heart-monitoring device from Mayo Clinic promises earlier detection of heart issues using quantum sensors. Sweating in saunas has been shown to effectively detoxify microplastics from the body. Meanwhile, an experiment with psychedelics revealed surprising benefits for glucose control. Plus, research on mitochondrial proteins hints at new ways to extend lifespan.
34 snips
Dec 18, 2025 • 58min
The Science of Erotic Altered States | Biohacking Sex : 1382
Kimi Inch, a somatic therapist and educator renowned for her work at the crossroads of intimacy and trauma healing, discusses the transformative power of erotic play. She reveals how practices like breath and impact play can trigger healing neurochemical responses, connecting sexuality to personal development. Kimi emphasizes the importance of maturity and consent in erotic experiences, while exploring the balance of surrender and connection. Their conversation highlights fantasy as a key to understanding unmet needs and integrating sexuality into one’s overall well-being.
13 snips
Dec 16, 2025 • 1h 4min
Biohacking Fertility for Men and Women at Any Age : 1381
Dr. Ann Shippy, a board-certified physician and functional medicine expert, shares insights into optimizing fertility for future parents. She connects rising infertility rates with childhood health issues, emphasizing the impact of environmental toxins. Dr. Shippy highlights the importance of preconception health as a key to a child's development and explains that men play an equal role in fertility health. Nutrition, lifestyle changes, and addressing chronic issues can significantly improve outcomes, making preparation essential for prospective parents.
67 snips
Dec 14, 2025 • 16min
Your Brain Has A Sleep Switch (Do THIS To Turn It On) : 1380
Discover the brain's hidden switch that controls deep sleep and how it's often turned off. Learn about the surprising impacts of posture and meal timing on your sleep quality. Find out how gravity contributes to restless nights and the corrections you can make for better rest. Dive into the crucial 3-hour rule for food, and understand how light exposure affects melatonin production. With practical tips like using TrueDark glasses and optimizing your bedroom environment, you'll be equipped to enhance your sleep and wake up revitalized!
53 snips
Dec 12, 2025 • 52min
The One Thing Everyone Thinks They Can’t Afford… Until They Try It : 1379
In a captivating discussion, Jonathan Swanson, founder of Thumbtack and Athena, reveals the transformative power of delegation. He shares how offloading mundane tasks can enhance cognitive function, reduce stress, and improve sleep quality. Swanson emphasizes the emotional benefits assistants provide, becoming trusted allies in both work and personal life. The conversation covers practical strategies for leveraging executive assistants to reclaim time and focus on higher-value goals, highlighting the future potential of combining human skill with AI.
32 snips
Dec 11, 2025 • 48min
How To Sculpt a Perfect Jawline WITHOUT Surgery : 1378
Brandon Harris, founder of Jawzrsize and a former mixed martial artist, dives into the surprising benefits of jaw strength. He shares his journey from a severe jaw injury to developing a jaw resistance device that enhances oral health, cognitive function, and posture. The discussion reveals how targeted jaw training can combat issues like sleep apnea, improve digestion through increased saliva, and even support athletic performance. Brandon's insights challenge conventional views on jaw care, emphasizing its foundational role in overall health.
63 snips
Dec 9, 2025 • 52min
I Tried At-Home Ultrasound for My Brain : 1377
Jon Hacker, a biomedical engineer and CEO of NeurGear, shares insights on how focused ultrasound can help regulate the vagus nerve. He explains the detrimental effects of chronic stress and the sympathetic state many find themselves in. Jon discusses the science behind ultrasound's ability to activate the nervous system, and why traditional electrical stimulation often falls short. He also dives into the effects of trauma, the importance of vagal tone, and how daily use of ZenBud promotes resilience and emotional balance.
94 snips
Dec 7, 2025 • 12min
What If You Stop Eating For 72 Hours? : 1375
What if skipping food for 72 hours could actually reverse aging? Discover how the body traverses critical phases during fasting, triggering cellular repair through autophagy. Learn why short fasts fall short and what common mistakes can sabotage your progress. Dave shares insights on strengthening mitochondria, sharpening the mind, and refeeding safely after fasting. Plus, dive into the importance of listening to your body during this transformative journey.
81 snips
Dec 5, 2025 • 57min
The Real Reason Your Face Is Aging So Fast : 1376
Join Dr. Nayan Patel, a pharmacist and wellness entrepreneur known for his innovative skincare formulations, as he unpacks the science behind aging skin. He explains how nutrients like GHK copper peptides and glutathione can enhance collagen production and improve skin resilience. Discover the importance of delivery systems, including why transdermal methods outperform traditional skincare. Dr. Patel also shares tips on layering serums effectively and highlights the benefits of GHK for hair and skin. Get ready to upgrade your skincare routine!
132 snips
Dec 4, 2025 • 1h 1min
Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374
Ilan Sobel, CEO of BioHarvest Sciences, leads the charge in revolutionary plant-derived supplements. He discusses how their Botanical Synthesis technology creates potent compounds from grape cells without the waste of traditional methods. The conversation touches on VINIA's impressive clinical results, including a 70% increase in arterial dilation and cognitive benefits. They also delve into alternative compounds like verbascoside from olives and future innovations with saffron, making biohacking more accessible and sustainable.
