The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
Episodes
Mentioned books
72 snips
Sep 30, 2025 • 48min
Modafinil Masterclass: Clarity, Drive, and Longevity | Solo Pod : 1337
Discover the brain-boosting potential of Modafinil, a nootropic that enhances energy and focus without the jitters of caffeine. Learn how it improves cognitive functions like memory and reaction time, while also benefiting mitochondrial health and longevity. Dave shares personal experiences, scientific research, and practical tips on dosing and stack recommendations. He also contrasts Modafinil with traditional stimulants like Adderall and caffeine, providing insights into who should consider using it. Explore its real-world impact and emerging research on neuroprotection.
65 snips
Sep 28, 2025 • 11min
This Detox Organ Is Blocking Every Diet You Try (Here's The Fix) : 1336
The secret to weight loss and energy might lie in your liver. It plays a crucial role in metabolism, fat-burning, and hormone regulation. Common toxins can overwhelm this detox powerhouse, leading to sluggish bile flow and hormone imbalances. By incorporating specific nutrients and foods, like bitter greens and B vitamins, you can support liver health and detoxification. Learn practical tips to enhance bile flow and improve metabolic function. Say goodbye to stubborn weight with the right liver care!
84 snips
Sep 26, 2025 • 8min
10-Minute Weekly Update : 1335
Dive into a whirlwind of insights on longevity and health tech! Discover the reality check on rapamycin, revealing its inconsistent benefits for longevity. Learn about new precision approaches to targeting senescent cells with senolytics, ensuring tailored treatments. Explore the promising rise of AI in healthcare while addressing the crucial need for human oversight in diagnosis. Also, find out about federal pilots allowing AI to make Medicare decisions, raising important access concerns. Get actionable tips for a healthier week!
127 snips
Sep 25, 2025 • 1h 2min
Why you absolutely MUST take algae daily to protect your longevity : 1334
Catherine Arnston, the founder of ENERGYbits and a mitochondrial health expert, dives into the fascinating world of algae and its impact on longevity. She shares insights on why mitochondria decline after age 30, revealing the importance of superoxide dismutase (SOD) and glutathione in combating cellular aging. Catherine discusses her unique health regimen relying on spirulina and chlorella, and the science behind their benefits. With personal anecdotes and practical advice, this conversation serves as a guide to supercharge energy and optimize health.
50 snips
Sep 23, 2025 • 1h 4min
Steven Pinker: Outsmarting an Irrational World : 1333
In this engaging discussion, Steven Pinker, a renowned Harvard cognitive psychologist and bestselling author, dives into the quirks of human reasoning and decision-making. He explores cognitive biases, shedding light on why even the smartest individuals can fall prey to irrational thinking. Pinker explains the concept of 'common knowledge' and its critical role in shaping social norms. He also addresses how AI misunderstands human intelligence and offers insights into enhancing our mental models for better performance and longevity. It's a masterclass in cognitive optimization!
103 snips
Sep 21, 2025 • 10min
How To Clear Brain Fog (Simple Methods) : 1332
Are you struggling with brain fog? Discover the root causes and unlock the secrets to boosting your brain energy! Learn how to restore mitochondrial health with simple hacks like optimizing sleep, eating the right foods, and incorporating stress-free exercise. Uncover the four brain-damaging foods to avoid and essential nutrients that might be lacking in your diet. Plus, find out which supplements can effectively combat that mental sluggishness. It's time to clear the fog and regain your focus!
67 snips
Sep 19, 2025 • 1h 9min
Lisa Bilyeu: How to hack confidence : 1331
Lisa Bilyeu, co-founder of Quest Nutrition and creator of Women of Impact, dives deep into the mechanics of confidence. She reveals how confidence can be biologically hacked, connecting it to neuroplasticity and mitochondria. Listeners learn practical tools to transform fear into action, leveraging rituals and mindset shifts. Bilyeu emphasizes setting boundaries and reframing trauma as a source of strength. Her insights empower you to treat confidence as a skill to be developed, challenging traditional notions of self-doubt and personal limits.
112 snips
Sep 18, 2025 • 1h 10min
Biohacking Your Voice? Here's How to Do It : 1330
Roger Love, a celebrity voice coach who's trained stars like Bradley Cooper and Selena Gomez, explores the fascinating connection between voice and health. He reveals how to improve your vocal tone and emotional expression to enhance your presence and influence. Discover techniques for using breath and vocal mechanics that boost confidence and connect deeper with audiences. Love also discusses the therapeutic benefits of voice training and how mastering your sound can even protect you as you age. Unleash the power of your voice!
152 snips
Sep 16, 2025 • 57min
Tom Cruise’s Secret FEAR Hack (+ Stress Biohacks for Longevity) : 1329
Jim Murphy, a former professional baseball player turned Olympic coach and bestselling author of Inner Excellence, shares transformative strategies to conquer fear and master stress. He discusses how Olympic-level coaching rewires the brain for resilience and performance. Listeners will learn how childhood experiences impact adult behavior, the significance of embracing discomfort, and the role of compassion in overcoming challenges. Murphy also explains practical biohacks for cultivating courage and discusses the importance of viewing setbacks as opportunities for growth.
136 snips
Sep 14, 2025 • 16min
BONUS: How To Reverse Testosterone Decline After 40 (Biohacking Tips) : 1328
Many believe that declining testosterone is just a part of aging, but that’s a myth. The podcast reveals how lifestyle changes can naturally boost testosterone levels, even without medication. It dives into the importance of diet, sleep, and light exposure in hormone health. Discover which underrated boosters can enhance your well-being and energy. Practical tips for reversing testosterone decline are shared, challenging the narrative around aging and revealing empowering strategies for men over 40.
