Performance Around The Clock

Episode 19 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biological Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the honor to talk with one of the pillars of the circadian field - Dr. Joseph Takahashi.  Dr. Takahashi pioneered the use of forward genetics and positional cloning in mouse as a tool to discover genes that underlie neurobiology and behavior.  His discovery of clock genes led to a description of a conserved circadian clock mechanism in animals. In this podcast, we hear about how his lab discovered and cloned the mouse circadianClock gene.  In addition, we find out how circadian alignment of feeding, daily fasting and caloric restriction can combine to increase longevity.Dr. Takahashi has authored more than 300+ scientific publications and the recipient of many awards and distinctions including:The Honma Prize in Biological Rhythms ResearchNSF Presidential Young Investigator AwardSearle Scholars AwardBristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. W. Alden Spencer Award in Neuroscience from Columbia UniversityFellow of the American Academy of Arts and SciencesMember of the National Academy of SciencesMember of the National Academy of MedicineGruber Neuroscience Prize at the Society for NeuroscienceGuest:Dr. Joseph TakahashiChair of the Department of Neuroscience at UT Southwestern Medical CenterLoyd B. Sands Distinguished Chair in NeuroscienceX (formerly Twitter): @CircadianClockshttps://twitter.com/circadianclocksUT Southwestern profile:https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.htmlLab webpage:https://labs.utsouthwestern.edu/takahashi-labHost:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Dr. Bret Goodpaster, a leading expert in exercise physiology and metabolism, shares his vast knowledge on muscle health and aging. He discusses his pivotal research on the HealthABC and MoTrPAC projects, revealing how strength loss can outpace muscle loss in older adults. The episode delves into metabolic flexibility, VO2 max trends across ages, and the significance of nutrition and sleep in enhancing performance. Goodpaster emphasizes the importance of understanding exercise's molecular mechanisms for promoting longevity and well-being.

Dr. Bente Klarlund Pedersen discusses her research on myokines, exercise as medicine, and advocating for health initiatives. She explains the impact of exercise on the immune system, benefits for cancer prevention, and how muscle-derived factors improve metabolism. Dr. Pedersen also shares her journey into science, public policy, and promoting physical activity for overall health.

Dr. Mark Febbraio, head of Cellular and Molecular Metabolism Laboratory, discusses exercise, inflammation, and disease research. Topics include his transition from a triathlete to researcher, link between exercise and inflammation, leveraging knowledge to treat disease, and the effects of exercise on immunity and cognitive function.

This week’s episode of the Performance Around the Clock podcast (episode 15) comes from the Cell Symposium on Exercise Metabolism in Lisbon, Portugal. Dr. Amber Mueller, scientific editor at Cell Metabolism and co-organizer of the symposium talks to us about life as a scientific editor and about the field of exercise metabolism. Enjoy!Guest:Dr. Amber MuellerScientific Editor at Cell MetabolismX (formerly Twitter): @AmberMuellerPhDhttps://twitter.com/AmberMuellerPhDHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: hhttps://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

In episode 14 of the Performance Around the Clock podcast, Dr. Laura van Rosmalen, a WuTsai scholar and postdoctoral researcher at the Salk Institute joins us to talk about her work with voles and seasonal rhythms, diurnality, nocturnality and energy balance, and a surprising connection with RED-S (Relative Energy Deficiency in Sport). Enjoy!Guest:Dr. Laura van RosmalenWuTsai scholarSalk Institute for Biological StudiesX (formerly Twitter): @RosmalenLaurahttps://twitter.com/RosmalenLauraHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Dr. Amita Sehgal, a Howard Hughes investigator studying circadian rhythms and sleep, joins episode 13 of the podcast this week to talk about her career including the discovery of the Drosophila TIM gene and her pivotal role in the development of Drosophila as a model for the study of sleep. Enjoy!Guest:Dr. Amita SehgalJohn Herr Musser Professor in the neuroscience department at the Perelman School of Medicine at the University of Pennsylvaniahttps://www.med.upenn.edu/sehgallab/X (formerly Twitter): @amitasehhttps://twitter.com/amitasehHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

In this episode of the Performance Around the Clock podcast, we welcome Dr. Michael McCarthy, a biological psychiatrist at UCSD and the Veterans Medical Research Foundation. We talk about the latest in psychiatry and how circadian rhythms may be involved. Enjoy.Guest:Dr. Michael McCarthyProfiles:UCSD: https://profiles.ucsd.edu/michael.mccarthyVA: https://www.vmrf.org/copy-of-pi-chitra-mandyam-1Host:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

In episode 11 of the Performance Around the Clock podcast, we have the privilege of speaking with Professor John Hogenesch - a neuroscientist/genome biologist/chronobiologist at UC Department of Pediatrics at the Cincinnati Children’s Hospital Medical Center. Dr. Hogenesch talks about applying the “principles of circadian biology to hospital medicine”. Enjoy!Guest:Dr. John HogeneschProfessor, UC Department of PediatricsCincinnati Children’s Hospital Medical Centerhttps://www.cincinnatichildrens.org/bio/h/john-hogeneschX (formerly Twitter): @jbhclockhttps://twitter.com/jbhclockHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

In this special, 10th episode of the Performance Around the Clock podcast, we have the honor of speaking with Professor Greg Lemke of the Salk Institute. We discuss his distinguished scientific career from the early beginnings to the discovery of TAM receptor tyrosine kinases. Enjoy.Guest:Dr. Greg LemkeFrançoise Gilot-Salk Chair and professor in the Molecular Neurobiology LaboratorySalk Institute for Biological StudiesLaboratory: https://www.lemkelab.org/Salk page: https://www.salk.edu/scientist/greg-lemke/Host:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram:https://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/