Performance Around The Clock

Dr. Phyllis Zee, a leading expert in sleep and circadian health, shares her insights on various sleep disorders and the importance of professional diagnosis. She explores melatonin's surprising role in glucose metabolism and discusses how late-night eating can affect our hormones. Dr. Zee also highlights innovative methods for measuring circadian health and advocates for circadian health clinics, emphasizing the need for integrated approaches in managing sleep and metabolic issues.

Welcome to episode 24 of the Performance Around The Clock podcast.  We resume our series from the Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  In this episode, we are joined by Dr. Annie Curtis, a professor at the Royal College of Surgeons in Ireland (RCSI), who studies the intersection between circadian rhythms and the immune system.  We talk about how the timing of infection affects the immune response and the implications for vaccinations.  In addition, we hear about the intriguing role of mitochondria in this immune response. Thanks for listening.Guest:Dr. Annie CurtisAssociate ProfessorRoyal College of Surgeons in Ireland (RCSI)School of Pharmacy and Biomolecular SciencesPrincipal Investigator of the Tissue Engineering Research Group (TERG)Executive Committee for the Irish Society for Immunology between 2016-2020L’Oreal Women in Science Fellowship in 2017SFI Career Development Award in 2017Irish Research Council Laureate Award in 2018President of the Irish Society for Immunology 2020-2022SFI Frontiers Award in 2021Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast. In episode 23, we are joined by Dr. Emily Manoogian, one of the foremost experts on Time-Restricted Eating (TRE), to discuss her latest research on TRE in adults with metabolic syndrome. We will explore how to implement TRE and its various benefits. Dr. Manoogian will also share insights on using the myCircadianClock app in her clinical trials to track TRE and other circadian metrics. For more information, you can visit the myCircadianClock website at www.mycircadianclock.org. If you are interested in participating in a Type 2 Diabetes and TRE study, please get in touch with Dr. Manoogian at preventivecvresearch@health.ucsd.edu. Her latest study was published in the Annals of Internal Medicine: (https://pubmed.ncbi.nlm.nih.gov/39348690/). Thank you for tuning in.Time-Restricted Eating in Adults with Metabolic Syndrome: A Randomized Control Trialhttps://www.acpjournals.org/doi/10.7326/M24-0859Guest:Dr. Emily ManoogianHillblom Fellow, Staff Scientist at the Salk Institute for Biological StudiesX (Twitter): @EmilyManoogianClinical Trials with Dr. Pam Taub: https://cardiology.ucsd.edu/research/labs/taub/research/clinical-trials.html#TRE-x-T2D-Study myCircadianClock website:www.mycircadianclock.orgParticipate in a Type 2 Diabetes Study by emailing:preventivecvresearch@health.ucsd.edu Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 22 of the Performance Around the Clock podcast is another episode from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We are honored to host this week’s guest, Dr. Charlotte Förster, who epitomizes perseverance in her long scientific career studying circadian rhythms  We’ll talk about her work to understand  the circadian clock at the molecular and neuronal level, how the clock synchronizes with the day/night cycles and how the clock controls behavior.  You’ll also hear about her fascinating research on the synchronization of menstrual cycles with lunar cycles and its implications.  Dr. Förster is a professor in Neurobiology and Genetics at the University of Würzburg.  Thank you for listening.Guest:Dr. Charlotte ForsterChronobiology Professor, Neurobiology and Genetics, University of WürzburgLab website:https://www.biozentrum.uni-wuerzburg.de/en/neurogenetics/research/wg-foerster/charlotte-foerster/Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 21 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  This week’s guest is Dr. Achim Kramer who developed an assay (BodyTime) to determine internal circadian time.  He talks about the development of the assay and how it can be used in circadian medicine.  Dr. Kramer is Head of Chronobiology at Charité – Universitätsmedizin Berlin, the largest research hospital in Europe. Thank you for listening.Guest:Dr. Achim KramerHead of Chronobiology at Charité – Universitätsmedizin BerlinLab website:https://www.achim-kramer-lab.de/Body clock test:https://www.bodyclock.health/BodyTimeHigh-accuracy determination of internal circadian time from a single blood samplehttps://pubmed.ncbi.nlm.nih.gov/29953415/Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Performance Around the Clock episode 20 comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the pleasure to talk with Dr. Christoph Scheiermann who studies the role of circadian rhythms in immune response and how this impacts health and disease.  In particular, he’s known for his research on the recruitment and localization of leukocytes which is under circadian control.  This process plays a crucial role in immune response which can be leveraged to improve cancer immunotherapy and vaccination efficacy.  Learn more about his impactful research in this episode. Thanks for listening.Guest:Dr. Christoph ScheiermannFull ProfessorDepartment of Pathology and ImmunologyCentre Medical Universitaire (CMU)X (formerly Twitter): @ScheiermannLabhttps://twitter.com/ScheiermannLabLab webpage:http://scheiermannlab.de/Host:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/

Episode 19 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biological Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the honor to talk with one of the pillars of the circadian field - Dr. Joseph Takahashi.  Dr. Takahashi pioneered the use of forward genetics and positional cloning in mouse as a tool to discover genes that underlie neurobiology and behavior.  His discovery of clock genes led to a description of a conserved circadian clock mechanism in animals. In this podcast, we hear about how his lab discovered and cloned the mouse circadianClock gene.  In addition, we find out how circadian alignment of feeding, daily fasting and caloric restriction can combine to increase longevity.Dr. Takahashi has authored more than 300+ scientific publications and the recipient of many awards and distinctions including:The Honma Prize in Biological Rhythms ResearchNSF Presidential Young Investigator AwardSearle Scholars AwardBristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. W. Alden Spencer Award in Neuroscience from Columbia UniversityFellow of the American Academy of Arts and SciencesMember of the National Academy of SciencesMember of the National Academy of MedicineGruber Neuroscience Prize at the Society for NeuroscienceGuest:Dr. Joseph TakahashiChair of the Department of Neuroscience at UT Southwestern Medical CenterLoyd B. Sands Distinguished Chair in NeuroscienceX (formerly Twitter): @CircadianClockshttps://twitter.com/circadianclocksUT Southwestern profile:https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.htmlLab webpage:https://labs.utsouthwestern.edu/takahashi-labHost:Dr. Satchin Panda@SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Dr. Bret Goodpaster, a leading expert in exercise physiology and metabolism, shares his vast knowledge on muscle health and aging. He discusses his pivotal research on the HealthABC and MoTrPAC projects, revealing how strength loss can outpace muscle loss in older adults. The episode delves into metabolic flexibility, VO2 max trends across ages, and the significance of nutrition and sleep in enhancing performance. Goodpaster emphasizes the importance of understanding exercise's molecular mechanisms for promoting longevity and well-being.

Dr. Bente Klarlund Pedersen discusses her research on myokines, exercise as medicine, and advocating for health initiatives. She explains the impact of exercise on the immune system, benefits for cancer prevention, and how muscle-derived factors improve metabolism. Dr. Pedersen also shares her journey into science, public policy, and promoting physical activity for overall health.

Dr. Mark Febbraio, head of Cellular and Molecular Metabolism Laboratory, discusses exercise, inflammation, and disease research. Topics include his transition from a triathlete to researcher, link between exercise and inflammation, leveraging knowledge to treat disease, and the effects of exercise on immunity and cognitive function.