Performance Around The Clock

In episode 5 of the PATC podcast, ophthalmology expert Dr. Kajuha Shubota discusses key research on how light affects vision and overall health with host Dr. Satchin Panda. He explains how lack of time outdoors and violet light exposure is increasing myopia rates in children, and eyeglasses may exacerbate the issue. He shares how dry eye is linked to stress and lifestyle factors. For presbyopia, he discusses potential drug and lens replacement solutions to improve near vision. Throughout, Dr. Shubota emphasizes how the eye offers valuable insights into aging and diseases like Alzheimer’s, as improving ocular blood flow with light may boost brain function. He remains optimistic that innovations in glasses design and lighting can profoundly improve vision and wellbeing across all life stages.Guest:Dr. Kazuo TsubotaProfessor, Department of Ophthalmology, Graduate School of Medicine, Keio UniversityProfile: http://tsubota.ne.jp/en/profile/profile.htmlLab page: https://tsubota-lab.com/en/Host:X (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

In episode 4 of the podcast, Dr. Tinh-Hai Collet, a physician and principal investigator at Geneva University Hospital, discusses with Dr. Satchin Panda his experience combining lifestyle interventions like meal timing and circadian rhythms with medicine to manage chronic conditions in patients. We discuss Dr. Collet's research on time-restricted eating, including a 6-month randomized controlled trial in Switzerland. We also discuss implementing lifestyle changes like intermittent fasting under medical supervision, potential side effects, impacts on conditions like diabetes and hypertension, and the importance of spreading circadian health knowledge among more physicians. Overall, this conversation highlights the potential for optimizing meal timing and circadian rhythms, alongside medication when needed, to improve health outcomes.Guest:Dr. Tinh-Hai ColletDiabetes Center of the Geneva University Hospital (HUG)https://www.unige.ch/medecine/diabetescentre/membres/dr-tinh-hai-colletHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

In episode 3 of this podcast, sleep and circadian rhythm expert, professor Frank Scheer discusses how our internal body clocks regulate physiology and behaviors in a 24-hour cycle. He explains how measures like dim light melatonin onset and cortisol rhythms provide insights into circadian timing. The discussion covers how factors like light exposure, meal timing, and sleep impact circadian rhythms and health. Dr. Scheer shares research on misaligning behaviors and physiology through social jet lag, night shifts, and mistimed eating. He suggests strategies like optimizing meal timing and light exposure to realign circadian rhythms. Overall, the discussion highlights how adjusting daily behaviors can improve circadian alignment, metabolism, mood, and wellbeing. Enjoy.Guest:Dr. Frank ScheerProfessor of Medicine, Brigham and Women's HospitalDivision of Sleep and Circadian Disorders at HarvardX (formerly Twitter): @harvardsleepmedHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram:https://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 2 of Performance Around the Clock features Dr. Juleen Zierath who is a Professor of Physiology at the Karolinska Institutet and the University of Copenhagen. We discuss with Dr. Zierath about using exercise as medicine for metabolic diseases like obesity, diabetes, and cardiovascular disease. This includes how exercise affects multiple organs and systems in the body, improving insulin sensitivity, bone density, cognition, and more. Dr. Zierath shares research on optimal timing of exercise for blood sugar control, showing benefits from afternoon exercise over morning for diabetics. We also cover personalized exercise prescriptions, prenatal and preconception exercise impacts, and the importance of societal support and public policy in enabling exercise. The episode provides some scientific evidence and advice for using exercise to boost health.Guest:Dr. Juleen ZierathProfessor of Physiology at Karolinska Institutet and the University of Copenhagen.X (formerly Twitter): @JuleenRZierathHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://twitter.com/SatchinPandaInstagram:https://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Dr. Hiroki Ueda, a circadian rhythm researcher at the University of Tokyo, sheds light on the intricate dance of our biological clocks. He dives into how circadian rhythms can influence gene expression and overall health. Dr. Ueda reveals groundbreaking genetic tools for studying sleep patterns and discusses novel non-invasive methods for tracking sleep cycles in animal models. He emphasizes the critical role of sleep quality, particularly deep and REM sleep, and highlights the implications of sleep disturbances on health and longevity. This conversation is a fascinating exploration of how timing and genetics shape our well-being.