The Peter Attia Drive

Nick Stenson, co-host and health enthusiast, joins the conversation on the rising trend of GLP-1 agonists, including Ozempic and Mounjaro, originally developed for diabetes. They dive into the drugs' efficacy, safety profiles, and surprising side effects, especially when discontinued. The duo also discusses how resistance training can affect weight loss journeys with these medications. Plus, insights on the role of compounding pharmacies and a glimpse into promising treatments on the horizon make for a captivating and informative discussion.

Dive into the fascinating insights on liver health and the latest noninvasive diagnostic techniques. Explore how heart rate variability can enhance training and overall health. Discover the promising role of AI in medicine and what it means for the future. Learn about klotho's impact on brain health and the intriguing science of lactate metabolism. Peter also shares personal adjustments influenced by these discussions, blending science with practical health tips.

Tadej Pogačar, a three-time Tour de France champion, shares his secrets from the saddle. He discusses his 2020 victory and the lessons learned from tough years in 2022 and 2023. His training strategy includes intense simulations of steep climbs and a focus on heart rate and power metrics. Tadej highlights the importance of nutrition, detailing his offseason diet and carb intake during training. He also reflects on the challenges of racing dynamics and confidence rebuilding, offering a candid look into the life of a top-tier cyclist.

In this insightful discussion, Marty Makary, a renowned Johns Hopkins surgeon and bestselling author, tackles the persistent blind spots in medicine. He reveals how groupthink stifles innovation and discusses the shift from surgical to non-operative treatments for appendicitis. The conversation delves into the peanut allergy epidemic, the myths surrounding hormone replacement therapy, and the urgent need for reform in medical education. Makary pushes for critical questioning in healthcare practices to improve patient outcomes and embraces new approaches.

This session tackles the emotional impact of hair loss and how it varies for men and women. It dives into androgenic alopecia, discussing its genetic and hormonal roots, particularly the role of dihydrotestosterone (DHT). Different hair loss patterns between genders are explored, revealing unique traits for each. Listeners learn about a range of treatment options, including medications and hair transplants, alongside practical tips for choosing the right specialist. Get ready for insights that could change perspectives on aging and self-image!

Annie Duke, a decision strategist and World Series of Poker champion, dives into the art of decision-making under uncertainty. She reveals how poker serves as a model for real-world decisions, blending luck and skill. Duke discusses our narrow focus in decision matrices and the consequences of risk aversion on innovation. She introduces backcasting as a powerful planning tool, linking future visions to present actions. With her unique insights, she challenges listeners to think probabilistically and embrace diverse learning opportunities for better outcomes.

Sebastian Junger, an award-winning journalist and bestselling author, shares insights from his near-death experience in the hospital, which transformed his view on life and mortality. He discusses the profound impact of this brush with death, emphasizing a newfound gratitude and emotional awareness. The conversation explores the intersection of belief systems, the sacredness of life, and existential questions about the afterlife. Junger's reflections challenge listeners to contemplate their own perceptions of existence and the mysteries surrounding it.

David Allison, a leading expert in obesity and nutrition, discusses the complexities of nutrition science and its impact on obesity treatments. He critiques public health policies and emphasizes the limited success in combating obesity. The conversation highlights the rise of GLP-1 agonists and the ethical concerns surrounding their use. Allison also explores protein intake recommendations, advocating for more rigorous research standards in the field. Listeners gain insights into the evolving landscape of obesity treatment and the intricacies of dietary science.

Discover the intriguing role of uric acid in your health and its surprising link to conditions like cardiovascular disease and kidney stones. Unpack how dietary choices and lifestyle factors influence uric acid levels. Shift gears to explore protein's vital role in appetite and weight management as Peter discusses the protein leverage hypothesis. Learn how solid versus liquid protein impacts satiety and discover strategies for optimal protein intake to support your health goals. Plus, enjoy a lighthearted take on fashion with a spotlight on fanny packs!

Join George A. Brooks, a renowned integrative biology professor from UC Berkeley, as he demystifies lactate, challenging its status as merely a waste product. He reveals lactate's crucial role in energy production for muscles and the brain, especially during intense exercise. Dive into discussions on its implications in diseases like type 2 diabetes and cancer, while exploring its therapeutic potential in brain injuries. Brooks also contrasts the metabolic responses of elite athletes and highlights lactate's influence on physical performance and recovery.