The Peter Attia Drive

Eric Ravussin, a leading expert on obesity and metabolism, discusses his groundbreaking research on energy expenditure and its influence on aging. He delves into caloric restriction and its health benefits, including insights from the CALERIE study. The episode explores the complexities of measuring energy balance and appetite regulation, highlighting the impact of hormones and dietary habits. Ravussin also examines the potential of GLP-1 agonists and the future of metabolic research through technology and AI advancements.

Feng Zhang, a groundbreaking professor of neuroscience at MIT and a leader in gene editing, discusses his pioneering work with CRISPR technology. He explores the revolutionary journey of CRISPR, from its discovery to its potential in treating genetic diseases like sickle cell anemia. Zhang also addresses the ethical debates surrounding gene editing, particularly concerning germline modifications. He shares insights from his personal journey, the impact of mentorship, and the future potential of genetic medicine, highlighting both challenges and innovative solutions in the field.

Belinda Beck, Ph.D., a leading authority in exercise physiology and founder of The Bone Clinic, shares invaluable insights on bone health. She discusses how childhood nutrition and activity set the stage for strong bones. Belinda emphasizes the importance of resistance training and essential nutrients to combat osteoporosis. She also dives into managing bone health through various sports and highlights the critical role of physical activity throughout life. With practical tips for parents, she empowers listeners to optimize bone density for themselves and their children.

Anna Lembke, M.D., Chief of the Stanford Addiction Medicine Clinic and author of 'Dopamine Nation,' delves into the neurobiology of addiction. She explains dopamine's pivotal role and discusses risk factors influencing addiction in younger generations. Lembke shares her insights on healthy coping mechanisms like cold exposure and the importance of support systems in recovery. She also highlights the dual nature of cannabis and the societal implications of behavioral addictions, providing a comprehensive framework for understanding and treating addiction.

Nick Stenson, co-host and health enthusiast, joins the conversation on the rising trend of GLP-1 agonists, including Ozempic and Mounjaro, originally developed for diabetes. They dive into the drugs' efficacy, safety profiles, and surprising side effects, especially when discontinued. The duo also discusses how resistance training can affect weight loss journeys with these medications. Plus, insights on the role of compounding pharmacies and a glimpse into promising treatments on the horizon make for a captivating and informative discussion.

Dive into the fascinating insights on liver health and the latest noninvasive diagnostic techniques. Explore how heart rate variability can enhance training and overall health. Discover the promising role of AI in medicine and what it means for the future. Learn about klotho's impact on brain health and the intriguing science of lactate metabolism. Peter also shares personal adjustments influenced by these discussions, blending science with practical health tips.

Tadej Pogačar, a three-time Tour de France champion, shares his secrets from the saddle. He discusses his 2020 victory and the lessons learned from tough years in 2022 and 2023. His training strategy includes intense simulations of steep climbs and a focus on heart rate and power metrics. Tadej highlights the importance of nutrition, detailing his offseason diet and carb intake during training. He also reflects on the challenges of racing dynamics and confidence rebuilding, offering a candid look into the life of a top-tier cyclist.

In this insightful discussion, Marty Makary, a renowned Johns Hopkins surgeon and bestselling author, tackles the persistent blind spots in medicine. He reveals how groupthink stifles innovation and discusses the shift from surgical to non-operative treatments for appendicitis. The conversation delves into the peanut allergy epidemic, the myths surrounding hormone replacement therapy, and the urgent need for reform in medical education. Makary pushes for critical questioning in healthcare practices to improve patient outcomes and embraces new approaches.

This session tackles the emotional impact of hair loss and how it varies for men and women. It dives into androgenic alopecia, discussing its genetic and hormonal roots, particularly the role of dihydrotestosterone (DHT). Different hair loss patterns between genders are explored, revealing unique traits for each. Listeners learn about a range of treatment options, including medications and hair transplants, alongside practical tips for choosing the right specialist. Get ready for insights that could change perspectives on aging and self-image!

Annie Duke, a decision strategist and World Series of Poker champion, dives into the art of decision-making under uncertainty. She reveals how poker serves as a model for real-world decisions, blending luck and skill. Duke discusses our narrow focus in decision matrices and the consequences of risk aversion on innovation. She introduces backcasting as a powerful planning tool, linking future visions to present actions. With her unique insights, she challenges listeners to think probabilistically and embrace diverse learning opportunities for better outcomes.