Derek, a bodybuilder with experience using anabolic steroids, joins the podcast to discuss the risks and rewards of performance-enhancing drugs and hormones. Topics include growth hormone, its effects on tissue restoration, muscle building, and fat burning. They also explore the evolution of drug use in bodybuilding and the causes of death in bodybuilders. Other topics discussed include the complex interplay of hormones, the impact of growth hormone on fertility, and the risks and challenges of bodybuilding. They also touch on the use of drugs for reducing prostate size and treating hair loss.

Ted Schaeffer, internationally recognized urologist specializing in prostate cancer, delves into prostate health, including aging-related urinary symptoms, the drug finasteride and post-finasteride syndrome. He explores the pathogenesis of prostate cancer, screening tools like PSA and MRI, and treatment options. Topics include surgical interventions, androgen deprivation therapy, and more. This episode covers various aspects of prostate health, from common problems to prevention and treatment.

Peter Attia welcomes David Sabatini and Matt Kaeberlein, experts on rapamycin and mTOR. They discuss the discovery of rapamycin, its potential benefits on lifespan, and the biology behind its effects. They also touch on the dosing of rapamycin in humans and reservations about prescribing it as a longevity drug. Topics include emergence of rapamycin as a geroprotective molecule, groundbreaking mouse study on lifespan extension, and the biochemistry of rapamycin and the mTOR protein complex.

This podcast explores the importance of metabolic health and how it affects the risk of developing chronic diseases. The host discusses various tests and metrics used to assess metabolic health. They also explore the limitations of using body weight and BMI as indicators and recommend alternative methods. The chapter also covers biomarker tests commonly performed and upcoming tips for improving them.

Neurobiology professor Andrew Huberman joins Peter Attia for a journal club discussing metformin's potential as a geroprotective drug and the power of belief. They analyze metformin's role in glucose regulation, compare it to berberine, and explore the Targeting Aging with Metformin trial. They also delve into how beliefs influence performance and weight loss, and the impact of beliefs on the brain's response to nicotine. They discuss the influence of beliefs on drug side effects and highlight the benefits of becoming a premium member.

In this podcast, Peter and Bob Kaplan discuss the importance of scientific literacy and the proper interpretation of studies. They cover topics such as study design, types of studies, clinical trials, statistical significance, and tips for reading scientific papers. They also explore the biases that can affect observational studies, discuss the concept of cluster randomization, and explain the difference between relative and absolute risk reduction. They emphasize the need for diligence and attention to detail when reading scientific studies, and provide a step-by-step guide for reading and understanding scientific papers.

Genetics expert, Wendy Chung, explores the evolution of genetic research and delves into various topics including PKU, breast cancer, obesity, autism, and cardiovascular disease. She discusses the potential of gene therapy, the different types of genetic tests, and the challenges of genetic sequencing. The chapter also highlights the Guardian Study's success in genomic screening for rare diseases in newborns and explores the future of genetics in medicine.

Dr. Keith Flaherty, director of clinical research at the Massachusetts General Hospital Cancer Center, discusses the advancements in cancer therapeutics, including immunotherapy and targeted therapies. He also highlights the significant progress in early detection methodologies, such as liquid biopsies, which have the potential to identify the tissue of origin. The podcast explores the link between hormones and cancer, obesity and cancer, and the challenges in treating metastatic cancer. It delves into the interplay between the immune system and cancer, the role of mutated genes, and the potential of combining targeted therapies. Additionally, it discusses the difference in survival rates between stages of colon cancer, the importance of early detection, and advancements in detecting cancer DNA in the bloodstream.

In this episode, Peter Attia explains the importance of understanding genetics and genetic risks. He covers the basics of genetics, DNA, and inheritance. He discusses the influence of genetics and environment on traits, using height as an example. He also explores the difference between monozygotic and dizygotic twins and the advantages of studying twins in research. Additionally, he delves into the reasons for genetic testing and provides insights on interpreting results and choosing genetic tests.

Oliver Burkeman, author of Four Thousand Weeks: Time Management for Mortals, explores the illusion of time mastery and the fallacy of maximizing productivity. They discuss the trap of trying to control time, the paradox of being present, and the value of relationships. Additionally, they reflect on the battle with time and the struggle to prioritize. They also discuss the power of acceptance and embracing the limitations of productivity hacks. Finally, they highlight the benefits of incrementalism in productivity and the advantages of premium membership.