Board certified cardiologist, Michael Twyman, comments on Paul's blood lipids and discusses apoB, cardiovascular risks, oxidized LDL, and seed oils. They explore true indicators of cardiovascular risk, insulin resistance, the importance of nitric oxide, glyphosate problems, the Lp-PLA2 test, and mitochondrial health.

This week, Paul interviews his good friend and board certified family physician with a focus on prevention and optimisation care, Ken Berry. They indulge in a healthy conversation about ketogenic versus animal-based diets, views on carbohydrates and honey, and the concept of bio-individuality when it comes to the optimal diet for humans. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:09:25 Podcast begins 00:10:59 Ken’s bloodwork 00:14:44 How does Ken Berry define metabolic health? 00:34:49 Ken’s thoughts on seed oils 00:42:24 Ken and Paul’s differing thoughts on carbohydrates and fruit 01:15:14 The ancestral consistency of fruit and honey 01:31:34 Should people from different regions eat different diets? 01:56:44 The individualization of medical care and nutrition 01:58:44 The importance of organs Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order Bon Charge: https://boncharge.com, use code CARNIVOREMD for 15% off your order

Today, Paul interviews Tucker Goodrich, Wall Street technology extraordinaire and independent researcher, and Jeff Nobbs, co-founder and CEO of Zero Acre Farms. They take a deep dive into the epidemic of seed oil consumption. They examine conflicting arguments, and then explain why seed oils are likely making humans fat, diabetic, and causing atherosclerosis. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:08:14 Podcast begins 00:13:55 What are seed oils and why are they bad for us? 00:23:30 Ancestral consistency of seed oils and linoleic acid 00:42:40 How are seed oils processed? 00:51:40 Should we worry about trans fats? 00:56:40 Let’s talk about HNE and PUFAs 01:13:10 Endocannabinoids 01:30:40 Are seed oils inflammatory? 00:01:43 Diverticulosis 01:47:20 Seed oils & blindness 01:48:45 Closing remarks about linoleic acid Connect with Jeff: zeroacre.com jeffnobbs.com Connect with Tucker: yelling-stop.blogspot.com Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Our Sponsor LetsGetChecked: 20% off your order at www.TRYLGC.com/paulsaladino for 25% off  Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order

In today’s episode, Paul addresses longevity in terms of how his views differ from those in the longevity community that promote eating less meat and more vegetables. He touches on mTOR, leucine, methionine, and glycine, and ultimately answers the question of: Will an animal-based diet improve our vitality, but decrease our longevity? A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:08:59 Podcast begins 00:10:57 David Sinclair on longevity 00:12:10 What does mainstream medicine say about red meat & longevity? 00:14:00 What does the longevity community recommend as an ideal diet? 00:30:27 What are mice fed in most animal studies? 00:34:07 Why we don’t need to fear mTOR 00:40:17 Thoughts on leucine 00:50:27 Should we restrict our methionine intake?  00:56:57 Studies on the benefits of eating meat 1:00:37 The evolutionary consistency of an animal-based diet Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org   White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order Our Sponsor LetsGetChecked: Go to https://trylgc.com/paulsaladino and use code PAULSALADINO for 25% off

Tommy Wood makes his third appearance on Paul’s podcast to cover a wide range of topics. Tommy is a developmental neuroscientist and professor of pediatrics and neuroscience at University of Washington. In today’s podcast, Paul and Tommy chat about overall brain health and dementia, lipids, LDL, continuous glucose monitors, and seed oils. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:07:36 Podcast begins 00:10:25 Should we eat animal brain? 00:17:40 Debunking misconceptions about Alzheimer's & APOE4 00:26:55 Saturated fat & APOE4 00:32:15 Tommy’s thoughts on insulin resistance & linoleic acid 00:44:30 Tommy’s thoughts on the ”calories in, calories out” weight loss model 01:00:50 A better model for understanding Alzheimer’s & brain health 01:16:20 Blue zones and thoughts on retirement 1:22:05 Critical nutrients for brain health Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Bon Charge: https://boncharge.com, use code CARNIVOREMD for 15% off your order

On today's podcast, Paul talks about how diabetes is diagnosed, how it’s treated by mainstream medicine, what he believes it is caused by, and how you can reverse your diabetes or pre-diabetes without medication. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:07:33 Podcast begins 00:11:33 Mainstream recommendations for diabetes 00:20:25 Metabolic health of American adults 00:24:45 What causes diabetes? 00:30:03 The problems with linoleic acid 00:36:25 Diabetes physiology 00:46:30 HNE & Linoleic acid 00:52:00 Thoughts on olive oil 01:06:00 Type 1 Diabetes  Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Our Sponsor LetsGetChecked: Go to https://trylgc.com/paulsaladino and use code PAULSALADINO for 25% off Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order

Are plant defense chemicals real? Are they a problem for humans? Paul addresses these questions in today’s podcast along with why he believes they are harmful for many people at a molecular level. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:06:16 Podcast begins 00:09:15 What are plant defense chemicals? 00:16:50 An anecdote on removing vegetables and switching to animal-based 00:19:05 Animal and plant warfare  00:24:50 Vegetables through an anthropological lens 00:30:40 The effects of plant compounds on the gut 00:33:00 Debunking any benefits of vegetables in our diet 00:42:35 Plant compounds have negative side effects  00:46:14 The harmful effects of oxalates and other plant defense chemicals 1:00:30 The problem with lectins 1:08:30 Plants do not want to be eaten Link to Sal’s Story about healing through Animal-based eating: https://www.youtube.com/watch?v=gp13WsEL7P8 Hormetic stress: The benefit of SAUNA vs. broccoli: https://www.youtube.com/watch?v=DvKgXnKYfd0 Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order Colima Salt: drpaulsalt.com, for a free bag of Colima Sea Salt Bon Charge: https://boncharge.com, use code CAR

Today on the podcast, Paul talks with John Abramson, American physician, lecturer at Harvard, and author of the books, Overdosed America: The Broken Promise of American Medicine and Sickening: How Big Pharma Broke American Health Care and How We Can Repair It. They have the important conversation about the problems with profit-driven pharmaceutical companies, conflicts of interest in the medical world, and how changing medical education and the system at large is integral for a patient-focused path forward. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:09:57 Podcast begins  00:10:58 John’s backstory as a physician 00:17:40 The inner workings of pharmaceutical companies 00:28:00 John’s experience with the FBI 00:29:30 Details on the Vioxx case 00:37:35 Directed consumer marketing of pharmaceuticals 00:44:10 Details about the most recent Vioxx trial  00:46:10 Conflicts of interest in the medical world and thoughts on Statins 00:51:30 The Diabetes Prevention Program 00:59:45 Pharmaceutical companies’ spending 01:10:10 What is the way forward and how can we change medical education? Get in touch with John at john_abramson@hms.harvard.edu Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org  White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Higher Dose: www.higherdose.com/paul, or use code PAUL for 15% off your order Our Sponsor LetsGetChecked: Go to https://trylgc.com/paulsaladino and use code PAULSALADINO for 25% off

On today’s podcast, Paul dives deep into red meat and cancer. He shares science on why he does not believe red meat has any association to cancer, and sheds light on the anti-red-meat agenda that he has seen throughout Western medicine. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:07:46 Podcast begins 00:09:15 Mainstream beliefs about red meat and colon cancer 00:12:30 What about processed red meat? 00:14:60 Observational epidemiology versus interventional studies 00:18:25 Interventional studies on red meat & colon cancer 00:21:50 Where do misconceptions on red meat and cancer come from? 00:33:50 Studies in which consumption of animal products improved health outcomes  00:42:20 The anti-meat agenda in this country 00:46:25 Mechanisms of red meat that are claimed to cause cancer 00:52:45 Neu5Gc 00:58:10 Paul’s personal health journey 1:00:50 Additional resources on meat & cancer Sponsors: Heart & Soil: www.heartandsoil.co Carnivore MD Merch: www.kaleisbullshit.shop Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org   White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Bon Charge: https://boncharge.com, use code CARNIVOREMD for 15% off your order Our Sponsor LetsGetChecked: Go to https://trylgc.com/paulsaladino and use code PAULSALADINO for 25% off Ice Barrel: www.icebarrel.com, use code PAUL to get $125 off your order and FREE shipping

On this week’s podcast, Paul addresses hypertension. He discusses the epidemiology and causes of high blood pressure, the problem with Western medicine’s lens of high blood pressure, and how to reverse it with dietary and lifestyle changes. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey. Time Stamps: 00:08:17 Podcast begins 00:13:40 What does Western medicine believe that risk factors for hypertension are?  00:27:20 The health of Western medical professionals 00:31:10 How does Western medicine address hypertension? 00:34:25 The renin-angiotensin-aldosterone system 00:42:10 The link between hypertension and cardiovascular disease 00:45:25 Insulin resistance and hypertension 00:49:10 How should we treat hypertension? 00:49:25 Medications that improve insulin resistance (TZD medications) 00:59:10 Familial lipodystrophy 01:02:40 Metabolic health in American adults 01:05:50 The problem with linoleic acid Sponsors: White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Eight Sleep: www.eightsleep.com/carnivoremd to get $150 off your order Primal Pastures: www.primalpastures.com, use code CarnivoreMD for 10% off your first order Higher Dose: www.higherdose.com/paul for 15% off, or use code PAUL for 15% off your order