Oncotarget

Researchers discuss the use of cancer testis antigens as potential therapeutic targets for lung cancer, focusing on KK-LC-1 expression levels in different subtypes. They highlight the correlation between KK-LC-1 expression and histological subtypes, along with the association with increased tumor mutation burden. The chapter also delves into study limitations and the need for future research to establish targeted therapy thresholds for NSCLC.

View the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 25. https://www.oncotarget.com/archive/v12/i25/ Research Paper (Cover) - “Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas” https://doi.org/10.18632/oncotarget.28132 Research Paper - “Radiomics in predicting recurrence for patients with locally advanced breast cancer using quantitative ultrasound” https://doi.org/10.18632/oncotarget.28139 Research Paper - “Beneficial effect of KYP-2047, a propyl-oligopeptidase inhibitor, on oral squamous cell carcinoma” https://doi.org/10.18632/oncotarget.28147 Editorial - “Delivering albumin-bound paclitaxel across the blood-brain barrier for gliomas” https://doi.org/10.18632/oncotarget.28018 (PDF Download) Research Perspective - “Cell fusion as a link between the SARS-CoV-2 spike protein, COVID-19 complications, and vaccine side effects” https://doi.org/10.18632/oncotarget.28088 Keywords - lung cancer, tumor microenvironment, radiomics, breast cancer, oral squamous cell carcinoma (OSCC), glioblastoma, cell fusion, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Dr. J. Kimble Frazer discusses new B-ALL findings in zebrafish models expressing transgenic human MYC. Zebrafish T-ALL models, insights into T-ALL genetics, and challenges in B-ALL modeling are explored. The podcast delves into gene expression patterns in B and T cells, key changes in leukemia models, and comparative analysis of H-MYC and ALLs in leukemia research.

Exploring the role of CrkL in controlling T cell migration to GvHD target organs and its impact on graft-versus-tumor responses. Understanding how CrkL-deficient T cells fail to polymerize actin and migrate properly, leading to defective clearance of tumors. Highlighting the importance of T cell recruitment to tissues for protective immunity while emphasizing the need for regulation to prevent inflammation and tissue damage.

Dr. Dung T. Le, an expert from The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, discusses an exploratory study on using metformin and rapamycin as maintenance therapy for metastatic pancreatic adenocarcinoma patients. The study shows potential synergy in tumor suppression and exceptional survival rates. Topics covered include challenges in measuring clinical activity, PET scan utilization, biologic activity analysis, and identification of immune cell subsets.

Exploring weight loss strategies for breast cancer survivors, the podcast discusses the significance of weight management, the impact of obesity on health outcomes, and research efforts at Johns Hopkins University. Insights are shared on a remote intervention's effect on weight loss, adipocytokines, and metabolic factors in early stage breast cancer survivors.

Exploring the use of iron chelators to selectively target cancer cells and reverse oncogenic transformation. Discussing the importance of iron in cancer cell metabolism and the evolution of thiosemicarbazone chelators. Highlighting the role of iron in driving cellular proliferation and the potential of iron chelators in combination therapies. Delving into the investigation of SK4 for targeting tumors with lot one overexpression and its cytotoxic effects on cancer cells.

The podcast discusses the role of GATA3 and APOBEC3B as prognostic markers in adrenocortical carcinoma, highlighting the overexpression of APOBEC3B and its link to chromosomal abnormalities. It explores how GATA3 regulates APOBEC3B expression and their impact on patient survival, providing novel insights into ACC.

Researchers investigate the role of CCL20 in promoting colorectal cancer growth through interactions with CCR6. Study delves into signaling pathways and mechanisms underlying this cancer-promoting molecule. Podcast explores feedback loop driving cancer progression and potential targeting options for treatment.

Listen to short summaries of the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 24. https://www.oncotarget.com/archive/v12/i24/ Research Paper (Cover) - “CCL20 induces colorectal cancer neoplastic epithelial cell proliferation, migration, and further CCL20 production through autocrine HGF-c-Met and MSP-MSPR signaling pathways” https://doi.org/10.18632/oncotarget.28131 Research Paper - “The potential of PIVKA-II as a treatment response biomarker in hepatocellular carcinoma: a prospective United Kingdom cohort study” https://doi.org/10.18632/oncotarget.28136 Research Paper - “Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast” https://doi.org/10.18632/oncotarget.28133 Research Paper - “Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids” https://doi.org/10.18632/oncotarget.28134 Research Paper - “Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses” https://doi.org/10.18632/oncotarget.28135 Research Paper - “Regional and temporal heterogeneity of epithelial ovarian cancer tumor biopsies: implications for therapeutic strategies” https://doi.org/10.18632/oncotarget.10505 Editorial - “Undetected Barrett’s esophagus: how do we improve early detection?” https://doi.org/10.18632/oncotarget.28005 (PDF Download) Research Perspective - “Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma” https://doi.org/10.18632/oncotarget.28077 Keywords - CCL20, colorectal cancer, hepatocellular carcinoma, biomarker, cellular aging, cellular quiescence, cancer patient, lung tumor, breast cancer, ovarian cancer, Barrett's esophagus, chronic liver disease, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957