Oncotarget

Dr. Nerymar Ortiz-Otero from Cornell University discusses how cancer-associated fibroblasts confer shear resistance to circulating tumor cells in prostate cancer metastasis. They explore the role of CAFs in promoting tumor cell survival and proliferation and the therapeutic potential of targeting CAF populations to prevent metastasis.

Explore the top 10 most-viewed oncology papers of 2021, covering topics like metformin and berberine for metabolic diseases, SARS-CoV-2 spike protein link to COVID-19 complications, physical activity's impact on telomere length, and the role of hedgehog signaling in gastric cancer. Dive into cancer therapy, gerostatics, melatonin's effect on prostate cancer, challenges of early pancreatic cancer detection, and inflammatory responses in organs.

Researchers Dr. Sandip Pravin Patel, Dr. Karen Yun, and Dr. Karen Mccowen discuss a rare incidence of type 1 diabetes induced by immunotherapy. They explore the challenges in diagnosing and managing this unique type of diabetes, along with the treatment options and impact on cancer outcomes. The podcast highlights the study identifying predictors of rapid onset type 1 diabetes and compares it to typical cases, providing valuable insights for healthcare professionals.

Dr. Sridhar Mani, a researcher from The Albert Einstein College of Medicine, discusses the use of microbial metabolite mimicry in drug discovery. Topics include the role of bacterial metabolites, designing molecules to mimic metabolite bindings, and enhancing drug efficacy with cost-effective synthesis. The podcast explores a novel approach to developing therapeutics with long-term efficacy and reduced side effects.

Exploring gene mutations and neoantigens in head and neck tumors, researchers investigate changes in neoantigen evolution from primary to recurrent tumors. Neoantigens play a crucial role in immune responses against cancer cells, potentially controlling tumor progression. Study findings reveal six shared genes with neoantigens showing correlation to improved survival outcomes in patients.

Oncotarget journal transitions to continuous publishing in 2022, allowing faster dissemination of research papers for authors and readers. The new model ensures timely availability of fully formatted articles with citation details in online formats, promoting quicker research application in a digital era.

Researchers discussed the rise of endometrial cancer among younger women, the challenges in diagnosing and treating heterogeneous tumors, and the limitations of using cell lines for research. A new study compared signaling pathways and genes in EC cell lines and tumors to identify parallels for regulating cancer progression.

Researchers discuss the challenges in developing specific antiviral drugs due to limited molecular targets in viruses. They explore the use of small compounds to inhibit herpes simplex virus proliferation. Collaborative research focuses on inhibitor compounds for various viruses, including Zika and cytomegalovirus. The podcast outlines the development of wide-range antiviral drugs and drug development plans. Researchers also explore inhibiting virus translation mechanisms for developing effective antiviral drugs.

OncoDNA's biomarker analysis led to 60% treatment recommendations being followed, with 93% based on NGS and multiple biomarker analysis. Late-stage patients treated with recommended therapies showed improved overall survival. The podcast discusses innovative cancer treatment solutions and patient outcomes.

Explore the evolution of neoantigens in head and neck squamous cell carcinoma from primary to metastatic tumors. The study reveals shared genes with predicted neoantigens, potentially triggering anti-tumor immune responses. Learn about the impact of T cell infiltration and granules in promoting anti-tumor responses and altering tumor microenvironments.