Oncotarget
Paper Spotlight: Novel Therapeutic Strategies Against Endometrial Cancer
Apr 7, 2022
The podcast explores the rise of endometrial cancer, the potential side effects of hysterectomies, and the research on the (pro)renin receptor in endometrial cancer biology. They discuss innovative therapeutic approaches, the role of PRR in cancer cell growth, viability, and its implications for diagnosis and treatment.
07:21
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Quick takeaways
- The overexpression of the Pro-Rennan Receptor (PRR) in endometrial cancer tissue impacts cancer cell growth and viability, suggesting PRR as a potential therapeutic target.
- The soluble prorenin receptor (SPRR) shows potential as a predictive diagnostic marker for endometrial cancer, with higher levels correlating with higher cancer grades.
Deep dives
Role of Pro-Rennan Receptor (PRR) in Endometrial Cancer Cell Growth
The Pro-Rennan Receptor (PRR) has been investigated for its role in endometrial cancer progression. In a recent study, researchers examined the ATP6AP2 gene that encodes the PRR and its involvement in activating the Rennan angiotensin system (RAS). They found that the PRR is overexpressed in endometrial cancer tissue compared to normal tissue, impacting cancer cell growth and viability. The study revealed that targeting the PRR through knockdown approaches could hinder cancer cell proliferation, suggesting PRR as a potential therapeutic target against endometrial cancer.
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