Oncotarget

Researchers Jennifer Y. Sheng and Vered Stearns discuss a remote weight loss program for breast cancer survivors. They highlight the importance of weight management post-diagnosis, stating its impact on cancer recurrence and mortality rates. The podcast delves into the results of the POWER-Remote Trial, showing promising outcomes for participants. The discussion emphasizes the need for tailored obesity treatments and extended coverage for such interventions.

Exploring the predictive significance of NOTCH1 variants in breast cancer, focusing on treatment sensitivity and survival rates in TNBC. Researchers investigate variant effects on cell behavior, growth patterns, and response to therapies for novel therapeutic targets in TNBC management.

Researcher Franco Cortese discusses enhancing human radioresistance for deep space exploration and colonization. Topics include gene therapy, organic molecule substitution, and slowing metabolic activity to mitigate radiation damage. The podcast explores strategies for tissue regeneration, Mars mission initiatives, and the connection between space radiation, longevity, and aging mechanisms.

Dr. Dae Joon Kim from the University of Texas Rio Grande Valley discusses the protective mechanism against UVB exposure in keratinocytes. Topics include AKT/14-3-3σ axis, TC-PTP translocation, apoptosis, and keratinocyte proliferation. The podcast delves into TC-PTP's role in skin carcinogenesis and cell apoptosis, as well as unveiling crucial mechanisms for its activity in skin cancer regulation.

Researchers discuss new pre-transplant AML treatment combinations with promising results, including ABT199/venetoclax with alkylating agents. The study aims to enhance cytotoxicity in AML cells and improve patient outcomes. Synergistic effects of drug combinations show potential clinical benefits for AML patients.

Dr. Bishal Gyawali discusses the challenges of affordable cancer drugs in low and middle-income countries. Topics include prioritizing effective treatments, disparities in drug pricing, and the need for policy changes to ensure access to essential cancer care services.

In this podcast, the focus is on how iron chelators can selectively target and deplete cancer cells of iron, hindering their growth and offering a promising treatment avenue. The discussion delves into the impact of iron chelators on cancer cell behavior, gene expression, and metastasis, highlighting the role of specific genes and pathways in affecting tumor development. Various natural and synthetic iron chelators are explored, with potential implications for reversing cancer hallmarks and providing new therapeutic options for patients.

Dr. Derrick Haslem and Dr. Lincoln Nadauld discuss their research on precision oncology in advanced cancer patients, highlighting improved overall survival and lower healthcare costs. They explore the challenges, outcomes, healthcare costs, benefits, integration, and potential of precision medicine in cancer care.

Explore the rare and aggressive adrenocortical carcinoma, with only 1-2 cases per million annually in the US. Learn about the symptoms and hormone levels associated with this cancer. Researchers identified GATA3 and APOBEC3B as prognostic markers, shedding light on the mechanisms of this ultra-rare disease.

Discover the link between chemo brain and cancer treatments, such as amifostine and etoposide, affecting memory and cognitive function. Researchers explore DNA double strand breaks and their influence on learning and memory, emphasizing the need for more research in this area.