Oncotarget

The podcast discusses the role of GATA3 and APOBEC3B as prognostic markers in adrenocortical carcinoma, highlighting the overexpression of APOBEC3B and its link to chromosomal abnormalities. It explores how GATA3 regulates APOBEC3B expression and their impact on patient survival, providing novel insights into ACC.

Researchers investigate the role of CCL20 in promoting colorectal cancer growth through interactions with CCR6. Study delves into signaling pathways and mechanisms underlying this cancer-promoting molecule. Podcast explores feedback loop driving cancer progression and potential targeting options for treatment.

Listen to short summaries of the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 24. https://www.oncotarget.com/archive/v12/i24/ Research Paper (Cover) - “CCL20 induces colorectal cancer neoplastic epithelial cell proliferation, migration, and further CCL20 production through autocrine HGF-c-Met and MSP-MSPR signaling pathways” https://doi.org/10.18632/oncotarget.28131 Research Paper - “The potential of PIVKA-II as a treatment response biomarker in hepatocellular carcinoma: a prospective United Kingdom cohort study” https://doi.org/10.18632/oncotarget.28136 Research Paper - “Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast” https://doi.org/10.18632/oncotarget.28133 Research Paper - “Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids” https://doi.org/10.18632/oncotarget.28134 Research Paper - “Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses” https://doi.org/10.18632/oncotarget.28135 Research Paper - “Regional and temporal heterogeneity of epithelial ovarian cancer tumor biopsies: implications for therapeutic strategies” https://doi.org/10.18632/oncotarget.10505 Editorial - “Undetected Barrett’s esophagus: how do we improve early detection?” https://doi.org/10.18632/oncotarget.28005 (PDF Download) Research Perspective - “Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma” https://doi.org/10.18632/oncotarget.28077 Keywords - CCL20, colorectal cancer, hepatocellular carcinoma, biomarker, cellular aging, cellular quiescence, cancer patient, lung tumor, breast cancer, ovarian cancer, Barrett's esophagus, chronic liver disease, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Exploring the toxic sunscreen chemical oxybenzone, known for promoting breast cancer and its estrogenic properties. Study reveals diet-dependent effects on mammary tumorigenesis in mouse models, emphasizing the role of saturated animal fat. Understanding the complex relationship between environmental toxins and breast cancer development.

Dr. Michael H. Roehrl from Memorial Sloan Kettering Cancer Center discusses the importance of P4HA1 protein as a prognostic marker in early-stage colorectal cancer. Proteomics technology is highlighted for discovering new biomarkers, guiding personalized treatment decisions, and improving patient outcomes.

Dr. Susan E. Erdman from MIT discusses using cholera toxin to combat age-associated obesity by stimulating immune responses. The podcast explores how gut microbiota affects obesity and chronic diseases. They delve into the properties of cholera toxin and its potential as an obesity solution, highlighting the benefits of early exposure to cholera vaccine for immune system health.

Researchers conducted a retrospective study of 20,000 lung cancer patients to analyze ALK gene rearrangement prevalence, offering insights into potential drug therapies. The study highlighted higher rates of ALK rearrangement in non-smokers and Asians, emphasizing the impact of patient demographics on the presence of the gene rearrangement.

Listen to the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 23. https://www.oncotarget.com/archive/v12/i23/ Research Paper (Cover) - “Anaplastic lymphoma kinase rearrangement prevalence in patients with advanced non-small cell lung cancer in the United States – retrospective real world data” https://doi.org/10.18632/oncotarget.28114 News - “Excitement for our future” https://doi.org/10.18632/oncotarget.28116 (PDF Download) Editorial - “Interferon-γ/IRF-1 pathway regulatory mechanisms of PD-L1 expression and relevance for immune checkpoint blockade in hepatocellular carcinoma (HCC)” https://doi.org/10.18632/oncotarget.27995 (PDF Download) Editorial - “Results from a randomized trial combining trastuzumab with a peptide vaccine suggest a role for HER2-targeted therapy in triple-negative breast cancer” https://doi.org/10.18632/oncotarget.27998 (PDF Download) Keywords - ALK rearrangement, non-small cell lung cancer (NSCLC), prevalence, multi-omics, molecular signatures, BRCA, HER2, triple negative breast cancer, breast cancer, hepatocellular carcinoma, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Researchers discuss the use of bacteria in tumor-targeted therapies for prostate cancer, highlighting a study on the bacteria strain CRC2631 in mouse models. The podcast explores the toxicity, tumor targeting, and genetic stability of CRC2631 compared to VNP2009, as well as its potential in reducing metastatic burden in prostate cancer through combination therapy with an immune checkpoint blockade.

Exploring the link between Benzophenone-3 and mammary tumorigenesis, the podcast delves into the effects of this endocrine disrupting chemical on breast cancer risk. Researchers highlight the diet-dependent nature of BP-3's promotion of tumor growth, pointing to the need for more studies in animal models and humans. The episode sheds light on the potential role of estrogenic chemicals in promoting breast cancer, emphasizing the importance of evaluating environmental EDCs in varying dietary contexts.