Role Of Germline Variants In The Metastasis Of Breast Carcinomas

Jul 7, 2022

Discussions center around the role of germline variants in breast cancer metastasis, emphasizing the importance of identifying genetic factors for effective treatment strategies. The impact of genetic makeup on metastasis is explored, including gene dysregulation and germline variants influencing metastatic spread and gene expression patterns.

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Exploring Germline Variants in Breast Cancer Metastasis

00:00 • 3min

Genetic Impact on Breast Carcinoma Metastasis

03:21 • 2min

A new research paper was published in Oncotarget on June 30, 2022, entitled, “Role of germline variants in the metastasis of breast carcinomas.” Most cancer-related deaths in breast cancer patients are associated with metastasis, a multistep, intricate process that requires the cooperation of tumor cells, tumor microenvironment and metastasis target tissues. It is accepted that metastasis does not depend on the tumor characteristics but the host’s genetic makeup. “However, there has been limited success in determining the germline genetic variants that influence metastasis development, mainly because of the limitations of traditional genome-wide association studies to detect the relevant genetic polymorphisms underlying complex phenotypes. “ Full press release: https://www.oncotarget.com/news/pr/oncotarget-role-of-germline-variants-in-the-metastasis-of-breast-carcinomas/ DOI: https://doi.org/10.18632/oncotarget.28250 Correspondence to: Aurelio A. Moya-García - Email: amoyag@uma.es Special Collection on Breast Cancer: https://www.oncotarget.com/collections/breast-cancer/ Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28250 Keywords: breast cancer, germline variants, epistasis, network analysis, seed and soil About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter – https://twitter.com/Oncotarget Facebook – https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram – https://www.instagram.com/oncotargetjrnl/ LinkedIn – https://www.linkedin.com/company/oncotarget/ Pinterest – https://www.pinterest.com/oncotarget/ LabTube – https://www.labtube.tv/channel/MTY5OA SoundCloud – https://soundcloud.com/oncotarget For media inquiries, please contact: media@impactjournals.com.