A new research paper was published in Oncotarget on June 30, 2022, entitled, “Role of germline variants in the metastasis of breast carcinomas.”
Most cancer-related deaths in breast cancer patients are associated with metastasis, a multistep, intricate process that requires the cooperation of tumor cells, tumor microenvironment and metastasis target tissues. It is accepted that metastasis does not depend on the tumor characteristics but the host’s genetic makeup.
“However, there has been limited success in determining the germline genetic variants that influence metastasis development, mainly because of the limitations of traditional genome-wide association studies to detect the relevant genetic polymorphisms underlying complex phenotypes. “
Full press release: https://www.oncotarget.com/news/pr/oncotarget-role-of-germline-variants-in-the-metastasis-of-breast-carcinomas/
DOI: https://doi.org/10.18632/oncotarget.28250
Correspondence to: Aurelio A. Moya-García - Email: amoyag@uma.es
Special Collection on Breast Cancer: https://www.oncotarget.com/collections/breast-cancer/
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Keywords: breast cancer, germline variants, epistasis, network analysis, seed and soil
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