Oncotarget

Researchers discuss the challenges in developing specific antiviral drugs due to limited molecular targets in viruses. They explore the use of small compounds to inhibit herpes simplex virus proliferation. Collaborative research focuses on inhibitor compounds for various viruses, including Zika and cytomegalovirus. The podcast outlines the development of wide-range antiviral drugs and drug development plans. Researchers also explore inhibiting virus translation mechanisms for developing effective antiviral drugs.

OncoDNA's biomarker analysis led to 60% treatment recommendations being followed, with 93% based on NGS and multiple biomarker analysis. Late-stage patients treated with recommended therapies showed improved overall survival. The podcast discusses innovative cancer treatment solutions and patient outcomes.

Explore the evolution of neoantigens in head and neck squamous cell carcinoma from primary to metastatic tumors. The study reveals shared genes with predicted neoantigens, potentially triggering anti-tumor immune responses. Learn about the impact of T cell infiltration and granules in promoting anti-tumor responses and altering tumor microenvironments.

Researchers discuss the use of cancer testis antigens as potential therapeutic targets for lung cancer, focusing on KK-LC-1 expression levels in different subtypes. They highlight the correlation between KK-LC-1 expression and histological subtypes, along with the association with increased tumor mutation burden. The chapter also delves into study limitations and the need for future research to establish targeted therapy thresholds for NSCLC.

View the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 25. https://www.oncotarget.com/archive/v12/i25/ Research Paper (Cover) - “Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas” https://doi.org/10.18632/oncotarget.28132 Research Paper - “Radiomics in predicting recurrence for patients with locally advanced breast cancer using quantitative ultrasound” https://doi.org/10.18632/oncotarget.28139 Research Paper - “Beneficial effect of KYP-2047, a propyl-oligopeptidase inhibitor, on oral squamous cell carcinoma” https://doi.org/10.18632/oncotarget.28147 Editorial - “Delivering albumin-bound paclitaxel across the blood-brain barrier for gliomas” https://doi.org/10.18632/oncotarget.28018 (PDF Download) Research Perspective - “Cell fusion as a link between the SARS-CoV-2 spike protein, COVID-19 complications, and vaccine side effects” https://doi.org/10.18632/oncotarget.28088 Keywords - lung cancer, tumor microenvironment, radiomics, breast cancer, oral squamous cell carcinoma (OSCC), glioblastoma, cell fusion, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Dr. J. Kimble Frazer discusses new B-ALL findings in zebrafish models expressing transgenic human MYC. Zebrafish T-ALL models, insights into T-ALL genetics, and challenges in B-ALL modeling are explored. The podcast delves into gene expression patterns in B and T cells, key changes in leukemia models, and comparative analysis of H-MYC and ALLs in leukemia research.

Exploring the role of CrkL in controlling T cell migration to GvHD target organs and its impact on graft-versus-tumor responses. Understanding how CrkL-deficient T cells fail to polymerize actin and migrate properly, leading to defective clearance of tumors. Highlighting the importance of T cell recruitment to tissues for protective immunity while emphasizing the need for regulation to prevent inflammation and tissue damage.

Dr. Dung T. Le, an expert from The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, discusses an exploratory study on using metformin and rapamycin as maintenance therapy for metastatic pancreatic adenocarcinoma patients. The study shows potential synergy in tumor suppression and exceptional survival rates. Topics covered include challenges in measuring clinical activity, PET scan utilization, biologic activity analysis, and identification of immune cell subsets.

Exploring weight loss strategies for breast cancer survivors, the podcast discusses the significance of weight management, the impact of obesity on health outcomes, and research efforts at Johns Hopkins University. Insights are shared on a remote intervention's effect on weight loss, adipocytokines, and metabolic factors in early stage breast cancer survivors.

Exploring the use of iron chelators to selectively target cancer cells and reverse oncogenic transformation. Discussing the importance of iron in cancer cell metabolism and the evolution of thiosemicarbazone chelators. Highlighting the role of iron in driving cellular proliferation and the potential of iron chelators in combination therapies. Delving into the investigation of SK4 for targeting tumors with lot one overexpression and its cytotoxic effects on cancer cells.