Oncotarget

Dr. Derrick Haslem and Dr. Lincoln Nadauld discuss their research on precision oncology in advanced cancer patients, highlighting improved overall survival and lower healthcare costs. They explore the challenges, outcomes, healthcare costs, benefits, integration, and potential of precision medicine in cancer care.

Explore the rare and aggressive adrenocortical carcinoma, with only 1-2 cases per million annually in the US. Learn about the symptoms and hormone levels associated with this cancer. Researchers identified GATA3 and APOBEC3B as prognostic markers, shedding light on the mechanisms of this ultra-rare disease.

Discover the link between chemo brain and cancer treatments, such as amifostine and etoposide, affecting memory and cognitive function. Researchers explore DNA double strand breaks and their influence on learning and memory, emphasizing the need for more research in this area.

Dr. Nerymar Ortiz-Otero from Cornell University discusses how cancer-associated fibroblasts confer shear resistance to circulating tumor cells in prostate cancer metastasis. They explore the role of CAFs in promoting tumor cell survival and proliferation and the therapeutic potential of targeting CAF populations to prevent metastasis.

Explore the top 10 most-viewed oncology papers of 2021, covering topics like metformin and berberine for metabolic diseases, SARS-CoV-2 spike protein link to COVID-19 complications, physical activity's impact on telomere length, and the role of hedgehog signaling in gastric cancer. Dive into cancer therapy, gerostatics, melatonin's effect on prostate cancer, challenges of early pancreatic cancer detection, and inflammatory responses in organs.

Researchers Dr. Sandip Pravin Patel, Dr. Karen Yun, and Dr. Karen Mccowen discuss a rare incidence of type 1 diabetes induced by immunotherapy. They explore the challenges in diagnosing and managing this unique type of diabetes, along with the treatment options and impact on cancer outcomes. The podcast highlights the study identifying predictors of rapid onset type 1 diabetes and compares it to typical cases, providing valuable insights for healthcare professionals.

Dr. Sridhar Mani, a researcher from The Albert Einstein College of Medicine, discusses the use of microbial metabolite mimicry in drug discovery. Topics include the role of bacterial metabolites, designing molecules to mimic metabolite bindings, and enhancing drug efficacy with cost-effective synthesis. The podcast explores a novel approach to developing therapeutics with long-term efficacy and reduced side effects.

Exploring gene mutations and neoantigens in head and neck tumors, researchers investigate changes in neoantigen evolution from primary to recurrent tumors. Neoantigens play a crucial role in immune responses against cancer cells, potentially controlling tumor progression. Study findings reveal six shared genes with neoantigens showing correlation to improved survival outcomes in patients.

Oncotarget journal transitions to continuous publishing in 2022, allowing faster dissemination of research papers for authors and readers. The new model ensures timely availability of fully formatted articles with citation details in online formats, promoting quicker research application in a digital era.

Researchers discussed the rise of endometrial cancer among younger women, the challenges in diagnosing and treating heterogeneous tumors, and the limitations of using cell lines for research. A new study compared signaling pathways and genes in EC cell lines and tumors to identify parallels for regulating cancer progression.