Oncotarget

Learn about Impact Journals' participation at the AACR Annual Meeting 2022, showcasing their dedication to cancer and aging research through journals like Oncotarget and Aging. Attendees are encouraged to connect with the Impact Journals team at booth No. 2012 and explore their website for more information.

Delve into the complexities of osteosarcoma, a rare bone cancer affecting both young and old patients. Learn how researchers are studying the IGF-1/mTOR and YAP/TAZ pathways to uncover potential treatment options. Discover the challenges of targeting mutations in osteosarcoma and the search for effective therapies.

Researchers are exploring virotherapy as a new method to treat multiple myeloma. Using oncolytic myxoma virus delivered through stem cell transplantation, they have seen promising results in eliminating MM cells in mouse models. The podcast discusses the efficacy of this adjunct virotherapy in targeting drug-resistant MM cells and improving survival rates.

Researchers Jennifer Y. Sheng and Vered Stearns discuss a remote weight loss program for breast cancer survivors. They highlight the importance of weight management post-diagnosis, stating its impact on cancer recurrence and mortality rates. The podcast delves into the results of the POWER-Remote Trial, showing promising outcomes for participants. The discussion emphasizes the need for tailored obesity treatments and extended coverage for such interventions.

Exploring the predictive significance of NOTCH1 variants in breast cancer, focusing on treatment sensitivity and survival rates in TNBC. Researchers investigate variant effects on cell behavior, growth patterns, and response to therapies for novel therapeutic targets in TNBC management.

Researcher Franco Cortese discusses enhancing human radioresistance for deep space exploration and colonization. Topics include gene therapy, organic molecule substitution, and slowing metabolic activity to mitigate radiation damage. The podcast explores strategies for tissue regeneration, Mars mission initiatives, and the connection between space radiation, longevity, and aging mechanisms.

Dr. Dae Joon Kim from the University of Texas Rio Grande Valley discusses the protective mechanism against UVB exposure in keratinocytes. Topics include AKT/14-3-3σ axis, TC-PTP translocation, apoptosis, and keratinocyte proliferation. The podcast delves into TC-PTP's role in skin carcinogenesis and cell apoptosis, as well as unveiling crucial mechanisms for its activity in skin cancer regulation.

Researchers discuss new pre-transplant AML treatment combinations with promising results, including ABT199/venetoclax with alkylating agents. The study aims to enhance cytotoxicity in AML cells and improve patient outcomes. Synergistic effects of drug combinations show potential clinical benefits for AML patients.

Dr. Bishal Gyawali discusses the challenges of affordable cancer drugs in low and middle-income countries. Topics include prioritizing effective treatments, disparities in drug pricing, and the need for policy changes to ensure access to essential cancer care services.

In this podcast, the focus is on how iron chelators can selectively target and deplete cancer cells of iron, hindering their growth and offering a promising treatment avenue. The discussion delves into the impact of iron chelators on cancer cell behavior, gene expression, and metastasis, highlighting the role of specific genes and pathways in affecting tumor development. Various natural and synthetic iron chelators are explored, with potential implications for reversing cancer hallmarks and providing new therapeutic options for patients.