Paper Spotlight: Iron Chelators in Cancer Treatment

Feb 10, 2022

In this podcast, the focus is on how iron chelators can selectively target and deplete cancer cells of iron, hindering their growth and offering a promising treatment avenue. The discussion delves into the impact of iron chelators on cancer cell behavior, gene expression, and metastasis, highlighting the role of specific genes and pathways in affecting tumor development. Various natural and synthetic iron chelators are explored, with potential implications for reversing cancer hallmarks and providing new therapeutic options for patients.

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Introduction

00:00 • 2min

Iron Chelator Action in Cancer Cell Cytotoxicity and Therapy

02:18 • 1min

Exploring Iron Chelators and their Potential in Cancer Treatment

03:47 • 3min

Iron is essential for human life, however, this element can also become toxic in high doses. Contrary to iron anemia, iron overload occurs when the body accumulates more iron than it can use, and this excess iron is damaging to cells and tissues. Famous for their atypical growth patterns, cancer cells accumulate a surplus of iron to support their irregular growth and metabolism. Thus, the metabolism of cancer cells may be exploited by targeting their proclivity to require and retain iron. “Iron chelators selectively deplete cancer cells of iron, exploiting cancer’s iron addiction – a trait displayed by a range of different cancers.” Iron chelators are compounds that can bind to iron and facilitate iron wasting. Depriving the body of iron using iron chelators has selectively cytotoxic effects in cancer cells. Some natural iron chelators include turmeric, quercetin, resveratrol, and green tea. Synthetic iron chelators include derivatives of 8-hydroxyquinoline, tachpyridine and deferoxamine. A considerable number of studies have shown that iron chelators can reverse some major catalysts and hallmarks of cancer—making iron chelators a promising treatment option for cancer patients. Researchers Gina Abdelaal and Stephany Veuger from Northumbria University reviewed the available research literature about the impact of iron chelation on cancer cell survival and the underlying mechanisms of action. Their review paper was published by Oncotarget in 2021 and entitled, “Reversing oncogenic transformation with iron chelation.” Full blog - https://www.oncotarget.org/2022/02/10/iron-chelators-in-cancer-treatment/ DOI - https://doi.org/10.18632/oncotarget.27866 Correspondence to - Gina Abdelaal - gina.abdelaal@northumbria.ac.uk Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27866 Press release - https://www.oncotarget.com/news/pr/reversing-oncogenic-transformation-with-iron-chelation/ Keywords - iron chelator, oncogenesis, selective cytotoxicity, hallmarks of cancer, NDRG1 About Oncotarget Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC: https://www.ImpactJournals.com Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957