Oncotarget
Trending With Impact: Adjunct Virotherapy Fights Multiple Myeloma
Mar 18, 2022
Researchers are exploring virotherapy as a new method to treat multiple myeloma. Using oncolytic myxoma virus delivered through stem cell transplantation, they have seen promising results in eliminating MM cells in mouse models. The podcast discusses the efficacy of this adjunct virotherapy in targeting drug-resistant MM cells and improving survival rates.
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Quick takeaways
- Virotherapy using MYXV through stem cell transplantation showed efficacy in eliminating residual myeloma cells in mice models.
- Combining oncolytic MYXV with specific drugs resulted in improved survival rates and reduced tumor burden in mouse models.
Deep dives
Viral Therapy for Multiple Myeloma
A promising approach to combat drug-resistant multiple myeloma involves using oncolytic viruses that selectively target and kill cancer cells while sparing normal cells. Researchers experimented with the Oncolytic Mixoma Virus, MYXV, delivered through stem cell transplantation in mice models, showing promising results in eliminating residual myeloma cells. Different strains of MYXV, including one genetically modified to express human tumor necrosis factor, were tested in vitro and in vivo, demonstrating efficacy in limiting myeloma progression and tumor burden. The study indicates the potential of oncolytic MYXV as an adjunct therapy for drug-resistant multiple myeloma, especially when combined with specific chemotherapeutic agents.
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