Experts discuss how preoperative hydroxyprogesterone may improve survival in breast cancer patients by modulating cellular stress response and inflammation. The role of progesterone in overcoming endocrine resistance is highlighted, along with the significance of non-coding RNAs and the SGK1/AP-1/NDRG1 axis in this process.

Researchers discuss the transformation of immunosuppressive mtKRAS tumors into immunostimulatory tumors using Nerofe and Doxorubicin. These drugs target KRAS mutations and show promising results in colorectal cancer by downregulating KRAS signaling and enhancing immune response activation.

Researchers discuss the role of ERβ in inflammatory breast cancer, highlighting its significance as a potential tumor suppressor and its implications for treatment outcomes in this rare and aggressive form of breast cancer.

Delve into the dark and bright sides of PLK1 in tumorigenesis as researchers unveil a novel GEM model to study its oncogenic potential. Learn how abnormal PLK1 expression contributes to chromosomal instability and potential therapeutic opportunities for targeted cancer treatments.

Researchers discuss the mechanism behind MCL-1 inhibitors, aiming to understand MCL-1 protein stability in cancer cells. The team explores the development of next-generation MCL-1 inhibitors for effective cancer treatment.

Exploration of Diphenyl ditelluride's anticancer activity in human colon cancer cells, including its ability to induce cell cycle arrest, DNA strand breaks, and form covalent complexes with DNA for potential anti-proliferative treatment.

Researchers Diwakar Davar and Roberta Zappasodi discuss the potential of GITR in cancer immunotherapy, its expression on immune cells, preclinical successes, challenges in clinical translation, and understanding immune responses for novel treatments.

Researchers conducted a study on using Metformin to prevent Metabolic Syndrome during Androgen Deprivation Therapy for advanced prostate cancer. The results showed no reduction in the risk of ADT-related Metabolic Syndrome or significant changes in PSA response.

Explore the history and impact of the Ride for Roswell charity bike ride event in Buffalo, NY. Learn about the significant contributions towards cancer research and patient care. Discover the fundraising rewards and team sponsorships available for the 2023 event, including support from scientific journals OncoTarget and Aging.

The podcast explores the role of ACSL4 in quadruple negative breast cancer as a potential biomarker, treatment predictor, and therapeutic target. ACSL4 is a lipid metabolic enzyme differentially expressed in breast tumors, with highest expression in mesenchymal and basal-like subtypes. Researcher Marie E. Monaco discusses the potential of utilizing ACSL4 status for predicting response to treatment regimens.