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Oncotarget

Oncotarget’s Top 10 Papers Published in 2023 (Crossref Data)

Feb 15, 2024
Discover the latest research in oncology with Crossref's Top 10 Oncotarget papers of 2023, covering topics like angiogenesis inhibition in HNSCC, prognostic index for gastric cancer, crosstalk in triple negative breast cancer, and current approaches in systemic AL amyloidosis.
05:26

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Quick takeaways

  • Everolimus inhibits angiogenesis in HNSCC by downregulating STAT3/HIF-1α/VEGF pathway.
  • A novel inflammation-based prognostic index predicts survival outcomes in gastric cancer patients.

Deep dives

Understanding Mechanisms of Everolimus in TP53 Mutant HNSCC

Everolimus downregulates stat 3 HIF-1 alpha, VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma. The authors from LSU Health Sciences Center sought to investigate the mechanism for everolimus induced inhibition of TP53 mutant HNSCC.

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