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Raw Areca Nut Betel Quid Consumption and Esophageal Cancer

Feb 22, 2024
Exploring the traditional practice of beetlequid chewing in regions like India and its link to oral, esophageal, and gastric cancers. Researchers delve into the role of the Mad2 gene in the development of esophageal cancer, shedding light on the mechanisms of gene deregulation and its implications for diagnosis and treatment.
06:58

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Quick takeaways

  • Consumption of raw areca nut betel quid is linked to oral, esophageal, and gastric cancers due to alkaloids and polyphenols.
  • The MAD-2 gene plays a crucial role in esophageal cancer progression, affected by raw areca nut betel quid.

Deep dives

Beetlequid Chewing and Cancer Risk

The traditional practice of beetlequid chewing, common in regions like Northeast India, involves consuming a mixture of raw arachan nut, slaked lime, and beetle leaf, releasing alkaloids and polyphenols. Despite its popularity, this practice is linked to increased risks of oral, esophageal, and gastric cancers due to the constituents of the mixture. Studies have shown a strong correlation between beetlequid chewing and cancer development, shedding light on the devastating impact of esophageal cancer globally.

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